STRINGSTRING
STN1 STN1 FAM9B FAM9B ENSANAP00000001331 ENSANAP00000001331 SLC4A1AP SLC4A1AP MUS81 MUS81 RAD50 RAD50 SLF1 SLF1 MCFD2 MCFD2 LOC110567274 LOC110567274 N4BP2L2 N4BP2L2 ENSANAP00000003190 ENSANAP00000003190 RAD54B RAD54B LOC105713780 LOC105713780 BRCA1 BRCA1 MRE11 MRE11 HELB HELB LOC105709820 LOC105709820 RPA3 RPA3 UNC93A UNC93A RBBP8 RBBP8 LOC105710913 LOC105710913 MCPH1 MCPH1 SSBP1 SSBP1 ENSANAP00000008481 ENSANAP00000008481 ENSANAP00000008925 ENSANAP00000008925 ENSANAP00000008993 ENSANAP00000008993 PITHD1 PITHD1 ENSANAP00000009900 ENSANAP00000009900 SYCP3 SYCP3 RPA1 RPA1 ENSANAP00000011115 ENSANAP00000011115 ATM ATM RAD52 RAD52 SASS6 SASS6 UIMC1 UIMC1 TOP3A TOP3A RECQL4 RECQL4 ENSANAP00000013863 ENSANAP00000013863 BRCC3 BRCC3 POLD1 POLD1 MPHOSPH9 MPHOSPH9 C12orf66 C12orf66 BRCA2 BRCA2 BRIP1 BRIP1 FICD FICD RAD51D RAD51D UNC93B1 UNC93B1 PIF1 PIF1 RECQL5 RECQL5 ENSANAP00000017921 ENSANAP00000017921 BARD1 BARD1 LOC105731879 LOC105731879 RAD51C RAD51C SUGP2 SUGP2 POLD2 POLD2 XRCC2 XRCC2 ENSANAP00000021022 ENSANAP00000021022 PRKRIP1 PRKRIP1 BABAM1 BABAM1 SUGP1 SUGP1 DDX52 DDX52 XRCC3 XRCC3 N4BP2 N4BP2 RPA4 RPA4 N4BP2L1 N4BP2L1 BABAM2 BABAM2 TOPBP1 TOPBP1 POLD3 POLD3 SAP130 SAP130 DMC1 DMC1 ATRX ATRX TOP3B TOP3B CNP CNP EME1 EME1 SEM1-2 SEM1-2 ENSANAP00000031551 ENSANAP00000031551 HELQ HELQ MEIOB MEIOB POLD4 POLD4 TM6SF2 TM6SF2 YJU2 YJU2 PALB2 PALB2 ENSANAP00000034595 ENSANAP00000034595 ENSANAP00000035667 ENSANAP00000035667 RAD54L RAD54L ABRAXAS2 ABRAXAS2 ABRAXAS1 ABRAXAS1 NBN NBN LURAP1 LURAP1 RAD51B RAD51B RAD51 RAD51 BLM BLM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
FAM9BCor1 domain-containing protein. (191 aa)
ENSANAP00000001331Uncharacterized protein. (234 aa)
SLC4A1APSolute carrier family 4 member 1 adaptor protein. (771 aa)
MUS81MUS81 structure-specific endonuclease subunit. (551 aa)
RAD50Zinc-hook domain-containing protein. (1312 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1039 aa)
MCFD2Multiple coagulation factor deficiency 2. (146 aa)
LOC110567274Uncharacterized protein. (126 aa)
N4BP2L2NEDD4 binding protein 2 like 2. (750 aa)
ENSANAP00000003190Reverse transcriptase domain-containing protein. (277 aa)
RAD54BUncharacterized protein. (646 aa)
LOC105713780RPA_C domain-containing protein. (274 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1827 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (642 aa)
HELBDNA helicase B. (1184 aa)
LOC105709820Smr domain-containing protein. (1665 aa)
RPA3Replication protein A3. (134 aa)
UNC93AUnc-93 homolog A. (434 aa)
RBBP8Uncharacterized protein. (898 aa)
LOC105710913Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (145 aa)
MCPH1Microcephalin 1. (858 aa)
SSBP1Single stranded DNA binding protein 1. (148 aa)
ENSANAP00000008481Uncharacterized protein. (298 aa)
ENSANAP00000008925Uncharacterized protein. (111 aa)
ENSANAP00000008993Uncharacterized protein. (127 aa)
PITHD1PITH domain containing 1. (211 aa)
ENSANAP00000009900Uncharacterized protein. (269 aa)
SYCP3Synaptonemal complex protein 3. (242 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
ENSANAP00000011115Uncharacterized protein. (65 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
RAD52RAD52 homolog, DNA repair protein. (419 aa)
SASS6SAS-6 centriolar assembly protein. (716 aa)
UIMC1Ubiquitin interaction motif containing 1. (736 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
RECQL4RecQ like helicase 4. (1208 aa)
ENSANAP00000013863Uncharacterized protein. (124 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (209 aa)
POLD1DNA polymerase delta 1, catalytic subunit. (1066 aa)
MPHOSPH9M-phase phosphoprotein 9. (1139 aa)
C12orf66Chromosome 12 open reading frame 66. (494 aa)
BRCA2BRCA2 DNA repair associated. (3404 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1252 aa)
FICDFIC domain containing. (457 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (327 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (597 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (678 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (986 aa)
ENSANAP00000017921RPA_C domain-containing protein. (232 aa)
BARD1BRCA1 associated RING domain 1. (769 aa)
LOC105731879RPA_C domain-containing protein. (256 aa)
RAD51CRAD51 paralog C. (367 aa)
SUGP2SURP and G-patch domain containing 2. (1098 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
XRCC2X-ray repair cross complementing 2. (295 aa)
ENSANAP00000021022Uncharacterized protein. (247 aa)
PRKRIP1PRKR interacting protein 1. (186 aa)
BABAM1BRISC and BRCA1 A complex member 1. (329 aa)
SUGP1SURP and G-patch domain containing 1. (696 aa)
DDX52DExD-box helicase 52. (599 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (398 aa)
N4BP2Uncharacterized protein. (1428 aa)
RPA4Replication protein A4. (233 aa)
N4BP2L1NEDD4 binding protein 2 like 1. (243 aa)
BABAM2BRISC and BRCA1 A complex member 2. (391 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1522 aa)
POLD3DNA polymerase delta 3, accessory subunit. (466 aa)
SAP130Sin3A associated protein 130. (1083 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (338 aa)
ATRXATRX chromatin remodeler. (2480 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
CNP2',3'-cyclic nucleotide 3' phosphodiesterase. (344 aa)
EME1Essential meiotic structure-specific endonuclease 1. (584 aa)
SEM1-2Uncharacterized protein. (87 aa)
ENSANAP00000031551DUF1725 domain-containing protein. (100 aa)
HELQHelicase, POLQ like. (1101 aa)
MEIOBMeiosis specific with OB-fold. (447 aa)
POLD4Uncharacterized protein. (107 aa)
TM6SF2Transmembrane 6 superfamily member 2. (356 aa)
YJU2YJU2 splicing factor homolog. (330 aa)
PALB2Partner and localizer of BRCA2. (1165 aa)
ENSANAP00000034595SAE2 domain-containing protein. (96 aa)
ENSANAP00000035667Uncharacterized protein. (88 aa)
RAD54LRAD54 like. (782 aa)
ABRAXAS2Abraxas 2, BRISC complex subunit. (376 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (369 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (744 aa)
LURAP1Leucine rich adaptor protein 1. (239 aa)
RAD51BRAD51 paralog B. (426 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
BLMBLM RecQ like helicase. (1415 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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