STRINGSTRING
ENSANAP00000040840 ENSANAP00000040840 ENSANAP00000000414 ENSANAP00000000414 WDR48 WDR48 ENSANAP00000000864 ENSANAP00000000864 ENSANAP00000001174 ENSANAP00000001174 MUS81 MUS81 ENSANAP00000001880 ENSANAP00000001880 N4BP2L2 N4BP2L2 HES1 HES1 LOC105713780 LOC105713780 BRCA1 BRCA1 LOC105709820 LOC105709820 RPA3 RPA3 MICAL3 MICAL3 LOC105723072 LOC105723072 PITHD1 PITHD1 FAN1 FAN1 FANCB FANCB CENPX CENPX RPA1 RPA1 TENT2 TENT2 SASS6 SASS6 POLQ POLQ TOP3A TOP3A POLI POLI NUTF2 NUTF2 FANCM FANCM FAAP24 FAAP24 POLN POLN ATR ATR BRCA2 BRCA2 BRIP1 BRIP1 SLX4 SLX4 ENSANAP00000017921 ENSANAP00000017921 LOC105731879 LOC105731879 RAD51C RAD51C UBE2T UBE2T REV3L REV3L FANCG FANCG FANCE FANCE MLH1 MLH1 FANCC FANCC REV1 REV1 N4BP2 N4BP2 ATRIP ATRIP RPA4 RPA4 N4BP2L1 N4BP2L1 ERCC1 ERCC1 ERCC4 ERCC4 SLX1A SLX1A PMS2 PMS2 RMI2 RMI2 FANCA FANCA TOP3B TOP3B ENSANAP00000030443 ENSANAP00000030443 CNP CNP EME1 EME1 POLK POLK USP1 USP1 MICAL1 MICAL1 PALB2 PALB2 TELO2 TELO2 FANCI FANCI FANCL FANCL POLH POLH MICAL2 MICAL2 ENSANAP00000039680 ENSANAP00000039680 FANCD2 FANCD2 FAAP100 FAAP100 RAD51 RAD51 BLM BLM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSANAP00000040840BMERB domain-containing protein. (687 aa)
ENSANAP00000000414Uncharacterized protein. (186 aa)
WDR48WD repeat domain 48. (677 aa)
ENSANAP00000000864NTF2 domain-containing protein. (127 aa)
ENSANAP00000001174NTF2 domain-containing protein. (127 aa)
MUS81MUS81 structure-specific endonuclease subunit. (551 aa)
ENSANAP00000001880NTF2 domain-containing protein. (127 aa)
N4BP2L2NEDD4 binding protein 2 like 2. (750 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
LOC105713780RPA_C domain-containing protein. (274 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1827 aa)
LOC105709820Smr domain-containing protein. (1665 aa)
RPA3Replication protein A3. (134 aa)
MICAL3Microtubule associated monooxygenase, calponin and LIM domain containing 3. (1917 aa)
LOC105723072DNA_mis_repair domain-containing protein. (626 aa)
PITHD1PITH domain containing 1. (211 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1018 aa)
FANCBFA complementation group B. (858 aa)
CENPXCentromere protein X. (127 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
TENT2Terminal nucleotidyltransferase 2. (484 aa)
SASS6SAS-6 centriolar assembly protein. (716 aa)
POLQDNA polymerase theta. (2434 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
POLIDNA polymerase iota. (860 aa)
NUTF2NTF2 domain-containing protein. (127 aa)
FANCMFA complementation group M. (2047 aa)
FAAP24Uncharacterized protein. (196 aa)
POLNDNA polymerase nu. (901 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2642 aa)
BRCA2BRCA2 DNA repair associated. (3404 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1252 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1804 aa)
ENSANAP00000017921RPA_C domain-containing protein. (232 aa)
LOC105731879RPA_C domain-containing protein. (256 aa)
RAD51CRAD51 paralog C. (367 aa)
UBE2TUbiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (197 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3134 aa)
FANCGFA complementation group G. (622 aa)
FANCEFA complementation group E. (536 aa)
MLH1DNA_mis_repair domain-containing protein. (757 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (558 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1253 aa)
N4BP2Uncharacterized protein. (1428 aa)
ATRIPATR interacting protein. (790 aa)
RPA4Replication protein A4. (233 aa)
N4BP2L1NEDD4 binding protein 2 like 1. (243 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (303 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (862 aa)
RMI2Uncharacterized protein. (136 aa)
FANCAFA complementation group A. (1386 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
ENSANAP00000030443NTF2 domain-containing protein. (118 aa)
CNP2',3'-cyclic nucleotide 3' phosphodiesterase. (344 aa)
EME1Essential meiotic structure-specific endonuclease 1. (584 aa)
POLKDNA polymerase kappa. (862 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (783 aa)
MICAL1Microtubule associated monooxygenase, calponin and LIM domain containing 1. (1112 aa)
PALB2Partner and localizer of BRCA2. (1165 aa)
TELO2Telomere maintenance 2. (940 aa)
FANCIFA complementation group I. (1333 aa)
FANCLFA complementation group L. (375 aa)
POLHDNA polymerase eta. (710 aa)
MICAL2Microtubule associated monooxygenase, calponin and LIM domain containing 2. (1122 aa)
ENSANAP00000039680Uncharacterized protein. (120 aa)
FANCD2FA complementation group D2. (1467 aa)
FAAP100FA core complex associated protein 100. (880 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
BLMBLM RecQ like helicase. (1415 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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