111 items (Aotus nancymaae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EDARADD	EDAR associated death domain. (214 aa)
	ENSANAP00000004890	Ig-like domain-containing protein. (127 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (460 aa)
	TRIM65	Tripartite motif containing 65. (515 aa)
	ENSANAP00000005537	Ig-like domain-containing protein. (137 aa)
	TNFSF14	TNF superfamily member 14; Belongs to the tumor necrosis factor family. (240 aa)
	LYN	LYN proto-oncogene, Src family tyrosine kinase. (498 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (159 aa)
	TIRAP	TIR domain containing adaptor protein. (221 aa)
	VCAM1	Vascular cell adhesion molecule 1. (725 aa)
	TNFRSF13C	TNF receptor superfamily member 13C. (183 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (571 aa)
	LAT	Linker for activation of T cells. (268 aa)
	TICAM1	Toll like receptor adaptor molecule 1. (538 aa)
	PIAS4	Protein inhibitor of activated STAT 4. (546 aa)
	SYK	Spleen associated tyrosine kinase. (636 aa)
	RELB	RELB proto-oncogene, NF-kB subunit. (563 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	PTGS2	Prostaglandin-endoperoxide synthase 2. (604 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
	TRAC	T cell receptor alpha constant. (134 aa)
	TRAF1	TNF receptor-associated factor. (467 aa)
	CCL19	C-C motif chemokine. (104 aa)
	LOC105725360	C-X-C motif chemokine. (107 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (317 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (165 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	ENSANAP00000014481	Ig-like domain-containing protein. (184 aa)
	ZAP70	Tyrosine-protein kinase. (605 aa)
	IL1R1	Interleukin 1 receptor type 1. (569 aa)
	BCL2A1	BCL2 related protein A1. (175 aa)
	XIAP	X-linked inhibitor of apoptosis. (497 aa)
	ENSANAP00000016399	Ig-like domain-containing protein. (137 aa)
	TMED7	Transmembrane p24 trafficking protein 7. (224 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (832 aa)
	LTB	Lymphotoxin beta; Belongs to the tumor necrosis factor family. (244 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (527 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	BLNK	B cell linker. (456 aa)
	CXCL1	C-X-C motif chemokine. (107 aa)
	EDA	Ectodysplasin A; Belongs to the tumor necrosis factor family. (392 aa)
	COIL	Coilin. (557 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	CD40	CD40 molecule. (274 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
	PIDD1	P53-induced death domain protein 1. (911 aa)
	ENSANAP00000020660	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (175 aa)
	CARD10	Caspase recruitment domain family member 10. (1034 aa)
	TNFAIP3	TNF alpha induced protein 3. (790 aa)
	LTBR	Lymphotoxin beta receptor. (432 aa)
	ENSANAP00000023957	UBIQUITIN_CONJUGAT_2 domain-containing protein. (173 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	NFKBIA	NFKB inhibitor alpha. (310 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (711 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	TRIM25	Tripartite motif containing 25. (620 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (320 aa)
	DDX58	DExD/H-box helicase 58. (855 aa)
	TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (505 aa)
	CCL4L2	C-C motif chemokine ligand 4 like 2. (103 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (486 aa)
	CSNK2A1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
	BCL10	BCL10 immune signaling adaptor. (233 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (455 aa)
	CARD11	Caspase recruitment domain family member 11. (1154 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (938 aa)
	PARP1	Poly [ADP-ribose] polymerase. (1040 aa)
	BCL2	BCL2 apoptosis regulator. (240 aa)
	BCL2L1	BCL2 like 1. (233 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (671 aa)
	PLAU	Plasminogen activator, urokinase. (443 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (175 aa)
	TRIM47	Tripartite motif containing 47. (605 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	ENSANAP00000031954	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (218 aa)
	TNFRSF11A	TNF receptor superfamily member 11a. (620 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	LOC110568050	SCY domain-containing protein. (89 aa)
	LTA	Lymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
	CARD14	Caspase recruitment domain family member 14. (1004 aa)
	EDAR	Ectodysplasin A receptor. (480 aa)
	TRAF2	TNF receptor-associated factor. (493 aa)
	CD14	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
	LCK	Tyrosine-protein kinase Lck; Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T- cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen- bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein [...] (541 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (128 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (540 aa)
	BIRC3	Baculoviral IAP repeat containing 3. (604 aa)
	MALT1	MALT1 paracaspase. (819 aa)
	UBE2I	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	CCL21	C-C motif chemokine ligand 21. (134 aa)
	CSNK2A2	Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
	BIRC2	Baculoviral IAP repeat containing 2. (618 aa)
	BPI	Bactericidal permeability increasing protein. (488 aa)
	LBP	Lipopolysaccharide binding protein. (481 aa)
	ERC1	ELKS/RAB6-interacting/CAST family member 1. (1082 aa)
	TRADD	TNFRSF1A associated via death domain. (312 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (761 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (900 aa)
	EDA2R	Ectodysplasin A2 receptor. (318 aa)
	LY96	Lymphocyte antigen 96. (160 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
	RELCH	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1250 aa)
	CSNK2B	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (234 aa)
	TICAM2	Toll like receptor adaptor molecule 2. (238 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	BCL2	ENSANAP00000011320	ENSANAP00000030335	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BCL2 apoptosis regulator.	0.409
ATM	BTK	ENSANAP00000011320	ENSANAP00000036529	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.405
ATM	CHUK	ENSANAP00000011320	ENSANAP00000041573	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Component of inhibitor of nuclear factor kappa B kinase complex.	0.410
ATM	ENSANAP00000020660	ENSANAP00000011320	ENSANAP00000020660	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.542
ATM	ENSANAP00000023957	ENSANAP00000011320	ENSANAP00000023957	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.542
ATM	IKBKG	ENSANAP00000011320	ENSANAP00000028833	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.890
ATM	MAP3K7	ENSANAP00000011320	ENSANAP00000018427	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.423
ATM	NFKB1	ENSANAP00000011320	ENSANAP00000031621	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Nuclear factor kappa B subunit 1.	0.447
ATM	PARP1	ENSANAP00000011320	ENSANAP00000029984	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Poly [ADP-ribose] polymerase.	0.464
ATM	PIAS4	ENSANAP00000011320	ENSANAP00000010186	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein inhibitor of activated STAT 4.	0.799
ATM	PIDD1	ENSANAP00000011320	ENSANAP00000020500	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	P53-induced death domain protein 1.	0.763
ATM	UBE2I	ENSANAP00000011320	ENSANAP00000003024	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.542
BCL10	BCL2	ENSANAP00000029227	ENSANAP00000030335	BCL10 immune signaling adaptor.	BCL2 apoptosis regulator.	0.406
BCL10	BIRC2	ENSANAP00000029227	ENSANAP00000039258	BCL10 immune signaling adaptor.	Baculoviral IAP repeat containing 2.	0.709
BCL10	BIRC3	ENSANAP00000029227	ENSANAP00000036979	BCL10 immune signaling adaptor.	Baculoviral IAP repeat containing 3.	0.836
BCL10	CARD10	ENSANAP00000029227	ENSANAP00000022147	BCL10 immune signaling adaptor.	Caspase recruitment domain family member 10.	0.801
BCL10	CARD11	ENSANAP00000029227	ENSANAP00000029812	BCL10 immune signaling adaptor.	Caspase recruitment domain family member 11.	0.994
BCL10	CARD14	ENSANAP00000029227	ENSANAP00000032880	BCL10 immune signaling adaptor.	Caspase recruitment domain family member 14.	0.800
BCL10	CHUK	ENSANAP00000029227	ENSANAP00000041573	BCL10 immune signaling adaptor.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.949
BCL10	DDX58	ENSANAP00000029227	ENSANAP00000028083	BCL10 immune signaling adaptor.	DExD/H-box helicase 58.	0.510