STRINGSTRING
GAB2 GAB2 DGKD DGKD SPHK2 SPHK2 AVP AVP ENSANAP00000005105 ENSANAP00000005105 GRB2 GRB2 RRAS2 RRAS2 SHC4 SHC4 PLPP1 PLPP1 FYN FYN PLA2G4F PLA2G4F RALB RALB PIK3R5 PIK3R5 DGKG DGKG PLA2G4E PLA2G4E MAPK3 MAPK3 DNM3 DNM3 AGPAT4 AGPAT4 PIK3R3 PIK3R3 DNM2 DNM2 RAPGEF4 RAPGEF4 AGPAT1 AGPAT1 ENSANAP00000039407 ENSANAP00000039407 RHOC RHOC ENSANAP00000005784 ENSANAP00000005784 CYTH2 CYTH2 FCER1G FCER1G DGKA DGKA LPAR3 LPAR3 AGT AGT AKT2 AKT2 DGKI DGKI PIK3CB PIK3CB ENSANAP00000007387 ENSANAP00000007387 INSR INSR ENSANAP00000008182 ENSANAP00000008182 AVPR2 AVPR2 RAPGEF3 RAPGEF3 RHEB RHEB PLD2 PLD2 RUFY4 RUFY4 AGPAT5 AGPAT5 AGTR1 AGTR1 ENSANAP00000009966 ENSANAP00000009966 SYK SYK DGKZ DGKZ MAP2K1 MAP2K1 LOC105716944 LOC105716944 GRM1 GRM1 TSC2 TSC2 PDGFC PDGFC ADCY2 ADCY2 PDGFD PDGFD PDGFRA PDGFRA RALGDS RALGDS LPAR1 LPAR1 DGKQ DGKQ PTK6 PTK6 PLPP2 PLPP2 CSDE1 CSDE1 ENSANAP00000013747 ENSANAP00000013747 GNA13 GNA13 RHEBL1 RHEBL1 PLCG2 PLCG2 ENSANAP00000014356 ENSANAP00000014356 ENSANAP00000014481 ENSANAP00000014481 MAPK1 MAPK1 PLPP3 PLPP3 DGKE DGKE AVPR1B AVPR1B PIP5K1B PIP5K1B JMJD7 JMJD7 SRMS SRMS CXCR2 CXCR2 PLD1 PLD1 CEP152 CEP152 PIK3CA PIK3CA AKT1 AKT1 ENSANAP00000019599 ENSANAP00000019599 DNM1 DNM1 GRM5 GRM5 PTPN11 PTPN11 ADCY4 ADCY4 EGF EGF ENSANAP00000021185 ENSANAP00000021185 GNA12 GNA12 INS INS F2 F2 PIP5K1C PIP5K1C GRM7 GRM7 GRM3 GRM3 GRM4 GRM4 PDGFRB PDGFRB LOC105730743 LOC105730743 LPAR2 LPAR2 ZNF408 ZNF408 PDGFB PDGFB LOC105706136 LOC105706136 ENSANAP00000037089 ENSANAP00000037089 EGFR EGFR ARF1 ARF1 PLA2G4A PLA2G4A ADCY9 ADCY9 PIK3CG PIK3CG PLCB2 PLCB2 GAB1 GAB1 ADCY6 ADCY6 ENSANAP00000024684 ENSANAP00000024684 CYTH1 CYTH1 MTOR MTOR SHC3 SHC3 KRAS KRAS KIT KIT RALA RALA GRM2 GRM2 AVPR1A AVPR1A PLA2G4D PLA2G4D LOC105720670 LOC105720670 ADCY1 ADCY1 RRAS RRAS ARF6 ARF6 LOC105727565 LOC105727565 CYTH3 CYTH3 PTRHD1 PTRHD1 TSC1 TSC1 SOS2 SOS2 ADCY3 ADCY3 SHC1 SHC1 LPAR4 LPAR4 F2R F2R ADCY7 ADCY7 PIK3CD PIK3CD AGPAT3 AGPAT3 AKT3 AKT3 PIK3R6 PIK3R6 SPHK1 SPHK1 SOS1 SOS1 RAF1 RAF1 DGKH DGKH GRM6 GRM6 ADCY5 ADCY5 PLCB3 PLCB3 AGPAT2 AGPAT2 GRM8 GRM8 PLA2G4B PLA2G4B PTGFR PTGFR LPAR6 LPAR6 NRAS NRAS PLCB4 PLCB4 CXCR1 CXCR1 FCER1A FCER1A PLCG1 PLCG1 KITLG KITLG PIK3R2 PIK3R2 MS4A2 MS4A2 PLCB1 PLCB1 ADCY8 ADCY8 PDGFA PDGFA PTK2B PTK2B HRAS HRAS CXCL8 CXCL8 PRKCA PRKCA SHC2 SHC2 LOC105727567 LOC105727567 CYTH4 CYTH4 DGKB DGKB PIK3R1 PIK3R1 MRAS MRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAB2GRB2 associated binding protein 2. (666 aa)
DGKDDiacylglycerol kinase. (1219 aa)
SPHK2Sphingosine kinase 2. (657 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
ENSANAP00000005105Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (210 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
RRAS2RAS related 2. (204 aa)
SHC4SHC adaptor protein 4. (628 aa)
PLPP1Phospholipid phosphatase 1. (285 aa)
FYNTyrosine-protein kinase. (537 aa)
PLA2G4FPhospholipase A2. (849 aa)
RALBRAS like proto-oncogene B. (206 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (878 aa)
DGKGDiacylglycerol kinase. (791 aa)
PLA2G4EPhospholipase A2. (863 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (859 aa)
AGPAT41-acylglycerol-3-phosphate O-acyltransferase 4. (378 aa)
PIK3R3Uncharacterized protein. (478 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (868 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1010 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (285 aa)
ENSANAP00000039407PIPK domain-containing protein. (574 aa)
RHOCRas homolog family member C. (193 aa)
ENSANAP00000005784Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (225 aa)
CYTH2Uncharacterized protein. (423 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
DGKADiacylglycerol kinase. (823 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (353 aa)
AGTAngiotensinogen; Belongs to the serpin family. (514 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
DGKIDiacylglycerol kinase. (1078 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
ENSANAP00000007387Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (215 aa)
INSRTyrosine-protein kinase receptor. (1302 aa)
ENSANAP00000008182Uncharacterized protein. (168 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (371 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (922 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
PLD2Phospholipase. (933 aa)
RUFY4RUN and FYVE domain containing 4. (600 aa)
AGPAT51-acylglycerol-3-phosphate O-acyltransferase 5. (364 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
ENSANAP00000009966DAGKa domain-containing protein. (203 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
DGKZDiacylglycerol kinase. (1122 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
LOC105716944Uncharacterized protein. (134 aa)
GRM1Glutamate metabotropic receptor 1. (1194 aa)
TSC2TSC complex subunit 2. (1807 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
RALGDSUncharacterized protein. (941 aa)
LPAR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (364 aa)
DGKQDiacylglycerol kinase. (913 aa)
PTK6Tyrosine-protein kinase. (451 aa)
PLPP2Phospholipid phosphatase 2. (296 aa)
CSDE1Cold shock domain containing E1. (843 aa)
ENSANAP00000013747Uncharacterized protein. (107 aa)
GNA13G protein subunit alpha 13. (325 aa)
RHEBL1RHEB like 1. (192 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
ENSANAP00000014356Uncharacterized protein. (181 aa)
ENSANAP00000014481Ig-like domain-containing protein. (184 aa)
MAPK1Mitogen-activated protein kinase. (376 aa)
PLPP3acidPPc domain-containing protein. (311 aa)
DGKEDiacylglycerol kinase. (567 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. (419 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (625 aa)
JMJD7Jumonji domain containing 7. (316 aa)
SRMSTyrosine-protein kinase. (482 aa)
CXCR2C-X-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (329 aa)
PLD1Phospholipase. (1091 aa)
CEP152Centrosomal protein 152. (1766 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (434 aa)
ENSANAP00000019599Uncharacterized protein. (318 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (857 aa)
GRM5Glutamate metabotropic receptor 5. (1210 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
ENSANAP00000021185Uncharacterized protein. (269 aa)
GNA12G protein subunit alpha 12. (380 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (828 aa)
GRM7Glutamate metabotropic receptor 7. (914 aa)
GRM3Glutamate metabotropic receptor 3. (879 aa)
GRM4Glutamate metabotropic receptor 4. (917 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1110 aa)
LOC105730743Uncharacterized protein. (183 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
ZNF408Zinc finger protein 408. (708 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
LOC105706136Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (411 aa)
ENSANAP00000037089Acyltransf_C domain-containing protein. (337 aa)
EGFREpidermal growth factor receptor. (705 aa)
ARF1Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (215 aa)
PLA2G4APhospholipase A2. (750 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1170 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1041 aa)
ENSANAP00000024684G_PROTEIN_RECEP_F1_2 domain-containing protein. (343 aa)
CYTH1Cytohesin 1. (408 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SHC3SHC adaptor protein 3. (598 aa)
KRASKRAS proto-oncogene, GTPase. (211 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
RALARAS like proto-oncogene A. (206 aa)
GRM2Glutamate metabotropic receptor 2. (872 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (418 aa)
PLA2G4DPhospholipase A2. (812 aa)
LOC105720670G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (370 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
RRASRAS related. (218 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
LOC105727565GNAS complex locus. (1040 aa)
CYTH3Cytohesin 3. (423 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (143 aa)
TSC1TSC complex subunit 1. (1163 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
SHC1SHC adaptor protein 1. (577 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1055 aa)
AGPAT3PlsC domain-containing protein. (344 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
SPHK1Sphingosine kinase 1. (469 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
DGKHDiacylglycerol kinase. (1220 aa)
GRM6Glutamate metabotropic receptor 6. (856 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1246 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1235 aa)
AGPAT21-acylglycerol-3-phosphate O-acyltransferase 2. (170 aa)
GRM8Glutamate metabotropic receptor 8. (908 aa)
PLA2G4BPhospholipase A2. (781 aa)
PTGFRProstaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
LPAR6Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (344 aa)
NRASUncharacterized protein. (189 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
CXCR1C-X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
FCER1AFc fragment of IgE receptor Ia. (257 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
PIK3R2Uncharacterized protein. (640 aa)
MS4A2Membrane spanning 4-domains A2. (241 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (230 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
SHC2SHC adaptor protein 2. (425 aa)
LOC105727567Uncharacterized protein. (247 aa)
CYTH4Cytohesin 4. (401 aa)
DGKBDiacylglycerol kinase beta. (428 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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