STRINGSTRING
PIK3R1 PIK3R1 RGS3 RGS3 PDK1 PDK1 PIK3R2 PIK3R2 CFL2 CFL2 LRRC4C LRRC4C PLCG1 PLCG1 EPHB3 EPHB3 ENSANAP00000000499 ENSANAP00000000499 NCK1 NCK1 ILK ILK LOC105719430 LOC105719430 NTN4 NTN4 NRAS NRAS CCDC125 CCDC125 LIMK2 LIMK2 ENSANAP00000002846 ENSANAP00000002846 RYK RYK SLIT3 SLIT3 ENSANAP00000003167 ENSANAP00000003167 GNAI3 GNAI3 PAK1 PAK1 LOC105713205 LOC105713205 SRGAP1 SRGAP1 SMO SMO MYL5 MYL5 TRPC1 TRPC1 PARD6G PARD6G LOC105709929 LOC105709929 RHOC RHOC ENSANAP00000005749 ENSANAP00000005749 ENSANAP00000006266 ENSANAP00000006266 SEMA5A SEMA5A SEMA4C SEMA4C ABLIM2 ABLIM2 PIK3CB PIK3CB SEMA6D SEMA6D LDAH LDAH SSH1 SSH1 CAMK2A CAMK2A ENSANAP00000008182 ENSANAP00000008182 RAC3 RAC3 ENSANAP00000008706 ENSANAP00000008706 EFNA1 EFNA1 LRRC4 LRRC4 ENSANAP00000009193 ENSANAP00000009193 ITGB1 ITGB1 SEMA4D SEMA4D ROBO1 ROBO1 MET MET EFNA4 EFNA4 EFNA2 EFNA2 EFNB2 EFNB2 BMPR1B BMPR1B NFATC4 NFATC4 SEMA7A SEMA7A UNC5C UNC5C PARD6B PARD6B EFNA3 EFNA3 PTK6 PTK6 NGEF NGEF CSDE1 CSDE1 ENSANAP00000013747 ENSANAP00000013747 UNC5B UNC5B PARD3 PARD3 PLCG2 PLCG2 TRPC4 TRPC4 MAPK1 MAPK1 SEMA6A SEMA6A DCC DCC UNC5A UNC5A PLXNB2 PLXNB2 ENSANAP00000015492 ENSANAP00000015492 PPP3CC PPP3CC LOC105709745 LOC105709745 EPHA7 EPHA7 GNAI1 GNAI1 PRKCZ PRKCZ PLXNA2 PLXNA2 GSK3B GSK3B EPHA5 EPHA5 CXCR4 CXCR4 NFATC3 NFATC3 SEMA3G SEMA3G SRMS SRMS EPHB2 EPHB2 PLXNA3 PLXNA3 ENAH ENAH NTNG2 NTNG2 PIK3CA PIK3CA SSH3 SSH3 PAK6 PAK6 CAMK2D CAMK2D PTPN11 PTPN11 ENSANAP00000020382 ENSANAP00000020382 EPHB4 EPHB4 MYL12B MYL12B LOC105718807 LOC105718807 ENSANAP00000021185 ENSANAP00000021185 MYL9 MYL9 PAK2 PAK2 NTN3 NTN3 SRGAP2 SRGAP2 ROCK2 ROCK2 ROBO3 ROBO3 CDK5 CDK5 ENSANAP00000022871 ENSANAP00000022871 SEMA3D SEMA3D PARD6A PARD6A EPHB1 EPHB1 SEMA3E SEMA3E SEMA3B SEMA3B BMPR2 BMPR2 CFL1 CFL1 PTCH1 PTCH1 ADAM15 ADAM15 ENSANAP00000024200 ENSANAP00000024200 ABL1 ABL1 ENSANAP00000024583 ENSANAP00000024583 EFNA5 EFNA5 WNT5A WNT5A PPP3R1 PPP3R1 RASA1 RASA1 KRAS KRAS EFNB3 EFNB3 NTNG1 NTNG1 UNC5D UNC5D CAMK2B CAMK2B EPHB6 EPHB6 SEMA4G SEMA4G SEMA6C SEMA6C ENSANAP00000026737 ENSANAP00000026737 BOC BOC RRAS RRAS PIK3CD PIK3CD RAF1 RAF1 PPP3CA PPP3CA SEMA3A SEMA3A RND1 RND1 NCK2 NCK2 ROBO2 ROBO2 TRPC6 TRPC6 TRPC3 TRPC3 SEMA4B SEMA4B TRPC7 TRPC7 PLXNB1 PLXNB1 SEMA4A SEMA4A RGMA RGMA RAC2 RAC2 EFNB1 EFNB1 WNT4 WNT4 PAK5 PAK5 PLXNA4 PLXNA4 SRC SRC SLIT1 SLIT1 PAK4 PAK4 LOC105725142 LOC105725142 PRKCA PRKCA GNAI2 GNAI2 ROCK1 ROCK1 TRPC5 TRPC5 FZD3 FZD3 HRAS HRAS SLIT2 SLIT2 DPYSL2 DPYSL2 EPHA6 EPHA6 NRP1 NRP1 SRGAP3 SRGAP3 EPHA4 EPHA4 ENSANAP00000034683 ENSANAP00000034683 NFATC2 NFATC2 SSH2 SSH2 SEMA5B SEMA5B SEMA4F SEMA4F SEMA3F SEMA3F CDC42 CDC42 RAC1 RAC1 SEMA6B SEMA6B EPHA10 EPHA10 PLXNA1 PLXNA1 GDF7 GDF7 SEMA3C SEMA3C ARSI ARSI CXCL12 CXCL12 PTK2 PTK2 L1CAM L1CAM ARHGEF12 ARHGEF12 WNT5B WNT5B PPP3CB PPP3CB PLXNB3 PLXNB3 LOC105730743 LOC105730743 LOC105713523 LOC105713523 EPHA1 EPHA1 BMP7 BMP7 DPYSL5 DPYSL5 LOC105710938 LOC105710938 LIMK1 LIMK1 ABLIM3 ABLIM3 FES FES PLXNC1 PLXNC1 PAK3 PAK3 ENSANAP00000039734 ENSANAP00000039734 CAMK2G CAMK2G ABLIM1 ABLIM1 PIK3R3 PIK3R3 EPHA2 EPHA2 MAPK3 MAPK3 NEO1 NEO1 NTN1 NTN1 FYN FYN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
RGS3Regulator of G protein signaling 3. (1077 aa)
PDK1Protein-serine/threonine kinase. (411 aa)
PIK3R2Uncharacterized protein. (640 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
LRRC4CLeucine rich repeat containing 4C. (640 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
EPHB3EPH receptor B3. (1000 aa)
ENSANAP00000000499Uncharacterized protein. (461 aa)
NCK1Cytoplasmic protein. (377 aa)
ILKIntegrin linked kinase. (452 aa)
LOC105719430ADF-H domain-containing protein. (212 aa)
NTN4Netrin 4. (688 aa)
NRASUncharacterized protein. (189 aa)
CCDC125Coiled-coil domain containing 125. (511 aa)
LIMK2LIM domain kinase 2. (638 aa)
ENSANAP00000002846ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (144 aa)
RYKReceptor like tyrosine kinase. (599 aa)
SLIT3Slit guidance ligand 3. (1530 aa)
ENSANAP00000003167Uncharacterized protein. (190 aa)
GNAI3Uncharacterized protein. (354 aa)
PAK1Non-specific serine/threonine protein kinase. (555 aa)
LOC105713205Uncharacterized protein. (178 aa)
SRGAP1SLIT-ROBO Rho GTPase activating protein 1. (1085 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (790 aa)
MYL5Myosin light chain 5. (164 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (793 aa)
PARD6GPar-6 family cell polarity regulator gamma. (356 aa)
LOC105709929ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (161 aa)
RHOCRas homolog family member C. (193 aa)
ENSANAP00000005749SAM domain-containing protein. (145 aa)
ENSANAP00000006266Non-specific serine/threonine protein kinase. (483 aa)
SEMA5ASemaphorin 5A. (1074 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (874 aa)
ABLIM2Actin binding LIM protein family member 2. (643 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1073 aa)
LDAHLipid droplet associated hydrolase. (325 aa)
SSH1Slingshot protein phosphatase 1. (1119 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
ENSANAP00000008182Uncharacterized protein. (168 aa)
RAC3Rac family small GTPase 3. (192 aa)
ENSANAP00000008706Uncharacterized protein. (140 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
LRRC4Leucine rich repeat containing 4. (603 aa)
ENSANAP00000009193Uncharacterized protein. (290 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
ROBO1Roundabout guidance receptor 1. (1684 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1391 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (208 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (215 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (333 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NFATC4Nuclear factor of activated T cells 4. (963 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (654 aa)
UNC5CUnc-5 netrin receptor C. (930 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (238 aa)
PTK6Tyrosine-protein kinase. (451 aa)
NGEFNeuronal guanine nucleotide exchange factor. (724 aa)
CSDE1Cold shock domain containing E1. (843 aa)
ENSANAP00000013747Uncharacterized protein. (107 aa)
UNC5BUnc-5 netrin receptor B. (946 aa)
PARD3Par-3 family cell polarity regulator. (1333 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (977 aa)
MAPK1Mitogen-activated protein kinase. (376 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
DCCDCC netrin 1 receptor. (1447 aa)
UNC5AUnc-5 netrin receptor A. (889 aa)
PLXNB2Plexin B2. (1878 aa)
ENSANAP00000015492Uncharacterized protein. (175 aa)
PPP3CCSerine/threonine-protein phosphatase. (520 aa)
LOC105709745Uncharacterized protein. (157 aa)
EPHA7EPH receptor A7. (998 aa)
GNAI1G protein subunit alpha i1. (354 aa)
PRKCZProtein kinase C. (594 aa)
PLXNA2Plexin A2. (1909 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
EPHA5EPH receptor A5. (1038 aa)
CXCR4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (413 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (813 aa)
SRMSTyrosine-protein kinase. (482 aa)
EPHB2EPH receptor B2. (1114 aa)
PLXNA3Plexin A3. (1873 aa)
ENAHWH1 domain-containing protein. (809 aa)
NTNG2Netrin G2. (530 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SSH3Slingshot protein phosphatase 3. (653 aa)
PAK6Non-specific serine/threonine protein kinase. (708 aa)
CAMK2DProtein kinase domain-containing protein. (544 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
ENSANAP00000020382Uncharacterized protein. (166 aa)
EPHB4EPH receptor B4. (876 aa)
MYL12BMyosin light chain 12B. (173 aa)
LOC105718807Eph LBD domain-containing protein. (271 aa)
ENSANAP00000021185Uncharacterized protein. (269 aa)
MYL9Myosin light chain 9. (172 aa)
PAK2Non-specific serine/threonine protein kinase. (525 aa)
NTN3Netrin 3. (574 aa)
SRGAP2Uncharacterized protein. (1071 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
ROBO3Roundabout guidance receptor 3. (1383 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (314 aa)
ENSANAP00000022871Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (394 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
PARD6APar-6 family cell polarity regulator alpha. (346 aa)
EPHB1EPH receptor B1. (967 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (774 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (755 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (190 aa)
PTCH1Patched 1. (1453 aa)
ADAM15ADAM metallopeptidase domain 15. (875 aa)
ENSANAP00000024200Protein kinase domain-containing protein. (279 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
ENSANAP00000024583Uncharacterized protein. (176 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PPP3R1Uncharacterized protein. (189 aa)
RASA1RAS p21 protein activator 1. (1049 aa)
KRASKRAS proto-oncogene, GTPase. (211 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (340 aa)
NTNG1Netrin G1. (539 aa)
UNC5DUnc-5 netrin receptor D. (958 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
EPHB6EPH receptor B6. (1032 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (844 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (960 aa)
ENSANAP00000026737ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (142 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1115 aa)
RRASRAS related. (218 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1055 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (766 aa)
RND1Rho family GTPase 1. (232 aa)
NCK2Cytoplasmic protein. (380 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (931 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (835 aa)
TRPC7Transient receptor potential cation channel subfamily C member 7; Belongs to the transient receptor (TC 1.A.4) family. (863 aa)
PLXNB1Plexin B1. (2142 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (761 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (453 aa)
RAC2Rac family small GTPase 2. (192 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
PLXNA4Plexin A4. (1894 aa)
SRCTyrosine-protein kinase. (542 aa)
SLIT1Slit guidance ligand 1. (1534 aa)
PAK4Non-specific serine/threonine protein kinase. (593 aa)
LOC105725142WH1 domain-containing protein. (553 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GNAI2G protein subunit alpha i2. (359 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1373 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SLIT2Slit guidance ligand 2. (1541 aa)
DPYSL2Dihydropyrimidinase like 2. (677 aa)
EPHA6EPH receptor A6. (1130 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
SRGAP3SLIT-ROBO Rho GTPase activating protein 3. (1099 aa)
EPHA4EPH receptor A4. (986 aa)
ENSANAP00000034683Uncharacterized protein. (164 aa)
NFATC2Nuclear factor of activated T cells 2. (923 aa)
SSH2Slingshot protein phosphatase 2. (1448 aa)
SEMA5BSemaphorin 5B. (1077 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (770 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
CDC42Uncharacterized protein. (191 aa)
RAC1Uncharacterized protein. (208 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (581 aa)
EPHA10EPH receptor A10. (897 aa)
PLXNA1Plexin A1. (1911 aa)
GDF7Growth differentiation factor 7. (421 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (748 aa)
ARSIArylsulfatase family member I. (572 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (128 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1077 aa)
L1CAML1 cell adhesion molecule. (1331 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
PPP3CBSerine/threonine-protein phosphatase. (439 aa)
PLXNB3Plexin B3. (1920 aa)
LOC105730743Uncharacterized protein. (183 aa)
LOC105713523ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (214 aa)
EPHA1EPH receptor A1. (969 aa)
BMP7Bone morphogenetic protein 7. (410 aa)
DPYSL5Dihydropyrimidinase like 5. (564 aa)
LOC105710938Uncharacterized protein. (179 aa)
LIMK1LIM domain kinase 1. (593 aa)
ABLIM3Actin binding LIM protein family member 3. (689 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (808 aa)
PLXNC1Plexin C1. (1539 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
ENSANAP00000039734Protein kinase domain-containing protein. (394 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (567 aa)
ABLIM1Actin binding LIM protein 1. (739 aa)
PIK3R3Uncharacterized protein. (478 aa)
EPHA2EPH receptor A2. (978 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
NEO1Neogenin 1. (1461 aa)
NTN1Netrin 1. (604 aa)
FYNTyrosine-protein kinase. (537 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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