STRINGSTRING
LOC105714684 LOC105714684 SOCS1 SOCS1 EPO EPO IFNAR1 IFNAR1 IL2RA IL2RA IL5RA IL5RA EPOR EPOR LOC105729323 LOC105729323 MTOR MTOR IL27RA IL27RA ENSANAP00000022162 ENSANAP00000022162 IL12A IL12A LOC105711369 LOC105711369 SOCS7 SOCS7 STAT1 STAT1 EGF EGF PTPN11 PTPN11 IFNE IFNE IL22RA1 IL22RA1 STAM STAM AKT1 AKT1 IL6R IL6R PIK3CA PIK3CA CCND3 CCND3 CCND1 CCND1 IL22 IL22 STAT6 STAT6 JAK2 JAK2 OSM OSM PTPN2 PTPN2 IL2 IL2 LEP LEP GHR GHR IL9 IL9 ENSANAP00000015746 ENSANAP00000015746 EP300 EP300 IL11 IL11 TSLP TSLP PIM1 PIM1 AOX1 AOX1 IL20RB IL20RB ENSANAP00000013875 ENSANAP00000013875 STAT4 STAT4 MYC MYC IFNL3 IFNL3 IFNLR1 IFNLR1 PDGFRA PDGFRA LOC105731455 LOC105731455 PIAS1 PIAS1 CNTFR CNTFR CREBBP CREBBP PIAS4 PIAS4 CSF3 CSF3 IFNGR1 IFNGR1 IL19 IL19 IL10RB IL10RB IL15 IL15 ENSANAP00000008016 ENSANAP00000008016 IL4 IL4 IL20 IL20 MCL1 MCL1 PIK3CB PIK3CB IFNAR2 IFNAR2 AKT2 AKT2 IL6ST IL6ST ENSANAP00000006063 ENSANAP00000006063 IL6 IL6 IL12RB1 IL12RB1 IL23A IL23A IL10 IL10 GRB2 GRB2 IL24 IL24 LOC105729267 LOC105729267 CSF2 CSF2 IL2RB IL2RB PIAS3 PIAS3 SOS2 SOS2 IL7 IL7 THPO THPO CSF2RA CSF2RA IL2RG IL2RG SOCS6 SOCS6 JAK3 JAK3 SOCS3 SOCS3 LIFR LIFR IFNG IFNG SOCS4 SOCS4 LEPR LEPR IL4R IL4R IFNK IFNK IL13RA1 IL13RA1 PIK3R2 PIK3R2 STAM2 STAM2 CNTF CNTF GALT GALT IL23R IL23R PDGFRB PDGFRB IL13 IL13 OSMR OSMR MPL MPL JAK1 JAK1 TYK2 TYK2 IL3 IL3 IRF9 IRF9 ENSANAP00000039717 ENSANAP00000039717 CDKN1A CDKN1A STAT5B STAT5B PIK3R3 PIK3R3 IL5 IL5 PRLR PRLR LOC105711370 LOC105711370 IFNGR2 IFNGR2 IL13RA2 IL13RA2 IFNL1 IFNL1 PIK3CD PIK3CD PTPN6 PTPN6 AKT3 AKT3 CTF1 CTF1 CSF3R CSF3R SOS1 SOS1 RAF1 RAF1 GFAP GFAP CCND2 CCND2 FHL1 FHL1 STAT2 STAT2 IL21R IL21R CISH CISH IL20RA IL20RA BCL2 BCL2 BCL2L1 BCL2L1 PIK3R1 PIK3R1 IL12RB2 IL12RB2 IL21 IL21 LIF LIF HRAS HRAS CSF2RB CSF2RB PDGFA PDGFA IL22RA2 IL22RA2 IL15RA IL15RA ENSANAP00000035262 ENSANAP00000035262 IL10RA IL10RA IL7R IL7R PRL PRL SOCS2 SOCS2 EGFR EGFR STAT3 STAT3 PIAS2 PIAS2 PDGFB PDGFB SOCS5 SOCS5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC105714684Uncharacterized protein. (591 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (194 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (511 aa)
IL2RAInterleukin 2 receptor subunit alpha. (272 aa)
IL5RAInterleukin 5 receptor subunit alpha. (420 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (509 aa)
LOC105729323Uncharacterized protein. (216 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
IL27RAInterleukin 27 receptor subunit alpha. (549 aa)
ENSANAP00000022162Uncharacterized protein. (163 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
LOC105711369Uncharacterized protein. (221 aa)
SOCS7Suppressor of cytokine signaling 7. (579 aa)
STAT1Signal transducer and activator of transcription. (781 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
IFNEInterferon epsilon. (179 aa)
IL22RA1Interleukin 22 receptor subunit alpha 1. (573 aa)
STAMSignal transducing adaptor molecule. (536 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (434 aa)
IL6RInterleukin 6 receptor. (378 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
IL22Interleukin 22. (179 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
OSMOncostatin M. (249 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
GHRGrowth hormone receptor. (638 aa)
IL9Interleukin 9. (144 aa)
ENSANAP00000015746SH2 domain-containing protein. (503 aa)
EP300E1A binding protein p300. (2401 aa)
IL11Interleukin 11. (199 aa)
TSLPThymic stromal lymphopoietin. (158 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (402 aa)
AOX1Aldehyde oxidase 1. (1338 aa)
IL20RBInterleukin 20 receptor subunit beta. (311 aa)
ENSANAP00000013875Uncharacterized protein. (317 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (463 aa)
IFNL3Uncharacterized protein. (199 aa)
IFNLR1Interferon lambda receptor 1. (519 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
LOC105731455FAD-binding PCMH-type domain-containing protein. (1332 aa)
PIAS1Protein inhibitor of activated STAT 1. (654 aa)
CNTFRCiliary neurotrophic factor receptor. (372 aa)
CREBBPCREB binding protein. (2445 aa)
PIAS4Protein inhibitor of activated STAT 4. (546 aa)
CSF3Colony stimulating factor 3. (207 aa)
IFNGR1Interferon gamma receptor 1. (483 aa)
IL19Interleukin 19. (214 aa)
IL10RBInterleukin 10 receptor subunit beta. (325 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
ENSANAP00000008016Uncharacterized protein. (215 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (152 aa)
IL20Interleukin 20. (176 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (352 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
IFNAR2Uncharacterized protein. (603 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
IL6STInterleukin 6 signal transducer. (922 aa)
ENSANAP00000006063SH2 domain-containing protein. (230 aa)
IL6Interleukin 6. (213 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (649 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
IL10Interleukin 10. (178 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
IL24Interleukin 24. (205 aa)
LOC105729267Uncharacterized protein. (238 aa)
CSF2Colony stimulating factor 2. (144 aa)
IL2RBInterleukin 2 receptor subunit beta. (551 aa)
PIAS3Uncharacterized protein. (628 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (177 aa)
THPOThrombopoietin. (307 aa)
CSF2RAUncharacterized protein. (412 aa)
IL2RGFibronectin type-III domain-containing protein. (345 aa)
SOCS6Suppressor of cytokine signaling 6. (534 aa)
JAK3Tyrosine-protein kinase. (1119 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
LIFRLIF receptor subunit alpha. (1141 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
LEPRLeptin receptor. (1165 aa)
IL4RInterleukin 4 receptor. (830 aa)
IFNKInterferon kappa. (167 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (425 aa)
PIK3R2Uncharacterized protein. (640 aa)
STAM2Signal transducing adaptor molecule 2. (525 aa)
CNTFCiliary neurotrophic factor. (200 aa)
GALTGalactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. (772 aa)
IL23RInterleukin 23 receptor. (575 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1110 aa)
IL13Interleukin 13. (146 aa)
OSMROncostatin M receptor. (977 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (689 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
TYK2Tyrosine-protein kinase. (1226 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (143 aa)
IRF9Interferon regulatory factor 9. (394 aa)
ENSANAP00000039717SOCS box domain-containing protein. (462 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (158 aa)
STAT5BSignal transducer and activator of transcription. (768 aa)
PIK3R3Uncharacterized protein. (478 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (621 aa)
LOC105711370Uncharacterized protein. (159 aa)
IFNGR2Interferon gamma receptor 2. (328 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (386 aa)
IFNL1Uncharacterized protein. (201 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1055 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (600 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CTF1Cardiotrophin 1. (201 aa)
CSF3RColony stimulating factor 3 receptor. (834 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (503 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
FHL1Four and a half LIM domains 1. (323 aa)
STAT2Signal transducer and activator of transcription. (849 aa)
IL21RInterleukin 21 receptor. (538 aa)
CISHCytokine inducible SH2 containing protein. (274 aa)
IL20RAInterleukin 20 receptor subunit alpha. (552 aa)
BCL2BCL2 apoptosis regulator. (240 aa)
BCL2L1BCL2 like 1. (233 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (860 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CSF2RBColony stimulating factor 2 receptor beta common subunit. (897 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (230 aa)
IL22RA2Interleukin 22 receptor subunit alpha 2. (251 aa)
IL15RAInterleukin 15 receptor subunit alpha. (240 aa)
ENSANAP00000035262Uncharacterized protein. (134 aa)
IL10RAInterleukin 10 receptor subunit alpha. (579 aa)
IL7RInterleukin 7 receptor. (459 aa)
PRLProlactin. (228 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
EGFREpidermal growth factor receptor. (705 aa)
STAT3Signal transducer and activator of transcription. (805 aa)
PIAS2Protein inhibitor of activated STAT 2. (621 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SOCS5Uncharacterized protein. (536 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
Server load: low (20%) [HD]