STRINGSTRING
LOC105714282 LOC105714282 HRAS HRAS KRT19 KRT19 ESR1 ESR1 GNAI2 GNAI2 KRT36 KRT36 LOC105714240 LOC105714240 SHC2 SHC2 LOC105727567 LOC105727567 SRC SRC KRT23 KRT23 PIK3R1 PIK3R1 BCL2 BCL2 EBAG9 EBAG9 TFF1 TFF1 KRT27 KRT27 KRT10 KRT10 MMP9 MMP9 FKBP4 FKBP4 GABBR2 GABBR2 PLCB3 PLCB3 ADCY5 ADCY5 PVALEF PVALEF RAF1 RAF1 SOS1 SOS1 KRT40 KRT40 LOC105710335 LOC105710335 AKT3 AKT3 PIK3CD PIK3CD ADCY7 ADCY7 SP1 SP1 ADCY1 ADCY1 ENSANAP00000026881 ENSANAP00000026881 KRT12 KRT12 LOC105731947 LOC105731947 KRT31 KRT31 LOC105711159 LOC105711159 LOC105707629 LOC105707629 ENSANAP00000025564 ENSANAP00000025564 CALM1 CALM1 KRAS KRAS SHC3 SHC3 FKBP5 FKBP5 TGFA TGFA KRT33B KRT33B ADCY6 ADCY6 ENSANAP00000023918 ENSANAP00000023918 MMP2 MMP2 FOS FOS ENSANAP00000023548 ENSANAP00000023548 CREB3 CREB3 CREB3L3 CREB3L3 KRT15 KRT15 IFITM10 IFITM10 ENSANAP00000021185 ENSANAP00000021185 GABBR1 GABBR1 ITPR1 ITPR1 ADCY4 ADCY4 ENSANAP00000019599 ENSANAP00000019599 KRT33A KRT33A AKT1 AKT1 PIK3CA PIK3CA CEP152 CEP152 LOC105732281 LOC105732281 KRT25 KRT25 POMC POMC ENSANAP00000018110 ENSANAP00000018110 GNAI1 GNAI1 CALM2 CALM2 CTSD CTSD CREB1 CREB1 HBEGF HBEGF MAPK1 MAPK1 CREB3L2 CREB3L2 HSPA2 HSPA2 ENSANAP00000014288 ENSANAP00000014288 KCNJ9 KCNJ9 ENSANAP00000013747 ENSANAP00000013747 ENSANAP00000013693 ENSANAP00000013693 CSDE1 CSDE1 KRT18 KRT18 PRKACB PRKACB NCOA3 NCOA3 PRKACA PRKACA LOC105705668 LOC105705668 KCNJ3 KCNJ3 HSP90B1 HSP90B1 ENSANAP00000012173 ENSANAP00000012173 CREB3L1 CREB3L1 ADCY2 ADCY2 ATF4 ATF4 GRM1 GRM1 MAP2K1 MAP2K1 NCOA1 NCOA1 ENSANAP00000009193 ENSANAP00000009193 ITPR2 ITPR2 KRT17 KRT17 LOC110569344 LOC110569344 CREB3L4 CREB3L4 ENSANAP00000008182 ENSANAP00000008182 PRKCD PRKCD KRT26 KRT26 ESR2 ESR2 KRT14 KRT14 PIK3CB PIK3CB KRT35 KRT35 ADCY8 ADCY8 AKT2 AKT2 LOC105709072 LOC105709072 CALML6 CALML6 KRT13 KRT13 GRB2 GRB2 ENSANAP00000005262 ENSANAP00000005262 LOC105711384 LOC105711384 SHC1 SHC1 GNAI3 GNAI3 ENSANAP00000003515 ENSANAP00000003515 ADCY3 ADCY3 NCOA2 NCOA2 ENSANAP00000003370 ENSANAP00000003370 SOS2 SOS2 PTRHD1 PTRHD1 GNAO1 GNAO1 LOC105727565 LOC105727565 HSPA1L HSPA1L LOC105729909 LOC105729909 KRT16 KRT16 PIK3R2 PIK3R2 KCNJ5 KCNJ5 GPER1 GPER1 ENSANAP00000000724 ENSANAP00000000724 PLCB4 PLCB4 NRAS NRAS CREB5 CREB5 KRT20 KRT20 KRT34 KRT34 KRT28 KRT28 MAPK3 MAPK3 KRT24 KRT24 RARA RARA SHC4 SHC4 KRT39 KRT39 ITPR3 ITPR3 PIK3R3 PIK3R3 ATF2 ATF2 KCNJ6 KCNJ6 HSP90AA1 HSP90AA1 KRT9 KRT9 HSP90AB1 HSP90AB1 ATF6B ATF6B ENSANAP00000038686 ENSANAP00000038686 PGR PGR LOC105730743 LOC105730743 NOS3 NOS3 LOC105706136 LOC105706136 OPRM1 OPRM1 CALML4 CALML4 EGFR EGFR ADCY9 ADCY9 ENSANAP00000036083 ENSANAP00000036083 KRT32 KRT32 CALM3 CALM3 PLCB2 PLCB2 LOC105705743 LOC105705743 PLCB1 PLCB1 CCDC170 CCDC170 HSPA8 HSPA8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC105714282HATPase_c domain-containing protein. (736 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
KRT19IF rod domain-containing protein; Belongs to the intermediate filament family. (400 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
GNAI2G protein subunit alpha i2. (359 aa)
KRT36Keratin 36; Belongs to the intermediate filament family. (467 aa)
LOC105714240HATPase_c domain-containing protein. (712 aa)
SHC2SHC adaptor protein 2. (425 aa)
LOC105727567Uncharacterized protein. (247 aa)
SRCTyrosine-protein kinase. (542 aa)
KRT23Keratin 23; Belongs to the intermediate filament family. (422 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
BCL2BCL2 apoptosis regulator. (240 aa)
EBAG9Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (257 aa)
TFF1Trefoil factor 1. (84 aa)
KRT27Keratin 27; Belongs to the intermediate filament family. (458 aa)
KRT10Keratin 10; Belongs to the intermediate filament family. (565 aa)
MMP9Matrix metallopeptidase 9. (703 aa)
FKBP4Peptidylprolyl isomerase. (459 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (887 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1235 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1246 aa)
PVALEFParvalbumin like EF-hand containing. (134 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
KRT40Keratin 40; Belongs to the intermediate filament family. (431 aa)
LOC105710335IF rod domain-containing protein; Belongs to the intermediate filament family. (423 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1055 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
SP1Sp1 transcription factor. (779 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
ENSANAP00000026881IF rod domain-containing protein; Belongs to the intermediate filament family. (415 aa)
KRT12Keratin 12; Belongs to the intermediate filament family. (495 aa)
LOC105731947Uncharacterized protein. (348 aa)
KRT31Keratin 31; Belongs to the intermediate filament family. (416 aa)
LOC105711159IF rod domain-containing protein; Belongs to the intermediate filament family. (450 aa)
LOC105707629Uncharacterized protein. (729 aa)
ENSANAP00000025564IF rod domain-containing protein; Belongs to the intermediate filament family. (171 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (150 aa)
KRASKRAS proto-oncogene, GTPase. (211 aa)
SHC3SHC adaptor protein 3. (598 aa)
FKBP5Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90) (By similarity). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (By similarity). (457 aa)
TGFATransforming growth factor alpha. (165 aa)
KRT33BKeratin 33B; Belongs to the intermediate filament family. (404 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1041 aa)
ENSANAP00000023918Uncharacterized protein; Belongs to the protein kinase superfamily. (318 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ENSANAP00000023548IF rod domain-containing protein; Belongs to the intermediate filament family. (402 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (501 aa)
KRT15Keratin 15; Belongs to the intermediate filament family. (455 aa)
IFITM10Interferon induced transmembrane protein 10. (227 aa)
ENSANAP00000021185Uncharacterized protein. (269 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (985 aa)
ITPR1Uncharacterized protein. (1010 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ENSANAP00000019599Uncharacterized protein. (318 aa)
KRT33AKeratin 33A; Belongs to the intermediate filament family. (404 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (434 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CEP152Centrosomal protein 152. (1766 aa)
LOC105732281Uncharacterized protein; Belongs to the heat shock protein 70 family. (636 aa)
KRT25Keratin 25; Belongs to the intermediate filament family. (450 aa)
POMCProopiomelanocortin. (263 aa)
ENSANAP00000018110Ion_trans domain-containing protein. (466 aa)
GNAI1G protein subunit alpha i1. (354 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (195 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (412 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
MAPK1Mitogen-activated protein kinase. (376 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (424 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (601 aa)
ENSANAP00000014288Uncharacterized protein. (331 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (391 aa)
ENSANAP00000013747Uncharacterized protein. (107 aa)
ENSANAP00000013693Uncharacterized protein. (110 aa)
CSDE1Cold shock domain containing E1. (843 aa)
KRT18IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (358 aa)
NCOA3Nuclear receptor coactivator. (1429 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
LOC105705668Uncharacterized protein. (441 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (435 aa)
HSP90B1HATPase_c domain-containing protein. (818 aa)
ENSANAP00000012173Uncharacterized protein; Belongs to the heat shock protein 70 family. (608 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
ATF4Activating transcription factor 4. (350 aa)
GRM1Glutamate metabotropic receptor 1. (1194 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
ENSANAP00000009193Uncharacterized protein. (290 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
KRT17Keratin 17; Belongs to the intermediate filament family. (432 aa)
LOC110569344IF rod domain-containing protein; Belongs to the intermediate filament family. (418 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (394 aa)
ENSANAP00000008182Uncharacterized protein. (168 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
KRT26Keratin 26; Belongs to the intermediate filament family. (468 aa)
ESR2Estrogen receptor 2. (530 aa)
KRT14Keratin 14; Belongs to the intermediate filament family. (474 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
KRT35Keratin 35; Belongs to the intermediate filament family. (455 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC105709072HATPase_c domain-containing protein. (329 aa)
CALML6Calmodulin like 6. (163 aa)
KRT13Keratin 13; Belongs to the intermediate filament family. (446 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ENSANAP00000005262Uncharacterized protein; Belongs to the protein kinase superfamily. (337 aa)
LOC105711384IF rod domain-containing protein; Belongs to the intermediate filament family. (446 aa)
SHC1SHC adaptor protein 1. (577 aa)
GNAI3Uncharacterized protein. (354 aa)
ENSANAP00000003515HATPase_c domain-containing protein. (532 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
ENSANAP00000003370Uncharacterized protein. (119 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (143 aa)
GNAO1G protein subunit alpha o1. (354 aa)
LOC105727565GNAS complex locus. (1040 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
LOC105729909IF rod domain-containing protein; Belongs to the intermediate filament family. (391 aa)
KRT16Keratin 16; Belongs to the intermediate filament family. (474 aa)
PIK3R2Uncharacterized protein. (640 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
ENSANAP00000000724IF rod domain-containing protein; Belongs to the intermediate filament family. (374 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
NRASUncharacterized protein. (189 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
KRT20Keratin 20; Belongs to the intermediate filament family. (421 aa)
KRT34Keratin 34; Belongs to the intermediate filament family. (436 aa)
KRT28Keratin 28; Belongs to the intermediate filament family. (402 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
KRT24Keratin 24; Belongs to the intermediate filament family. (525 aa)
RARARetinoic acid receptor alpha. (466 aa)
SHC4SHC adaptor protein 4. (628 aa)
KRT39Keratin 39; Belongs to the intermediate filament family. (491 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
PIK3R3Uncharacterized protein. (478 aa)
ATF2Activating transcription factor 2. (287 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (449 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (790 aa)
KRT9Keratin 9; Belongs to the intermediate filament family. (561 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (703 aa)
ATF6BActivating transcription factor 6 beta. (700 aa)
ENSANAP00000038686Uncharacterized protein; Belongs to the heat shock protein 70 family. (621 aa)
PGRProgesterone receptor. (935 aa)
LOC105730743Uncharacterized protein. (183 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
LOC105706136Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (411 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (441 aa)
CALML4Calmodulin like 4. (196 aa)
EGFREpidermal growth factor receptor. (705 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
ENSANAP00000036083IF rod domain-containing protein; Belongs to the intermediate filament family. (401 aa)
KRT32Keratin 32; Belongs to the intermediate filament family. (448 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1170 aa)
LOC105705743HATPase_c domain-containing protein. (629 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
CCDC170Coiled-coil domain containing 170. (646 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
Server load: low (18%) [HD]