STRINGSTRING
VEGFA VEGFA ENSANAP00000008182 ENSANAP00000008182 CREB3L4 CREB3L4 MAPK13 MAPK13 ENSANAP00000009193 ENSANAP00000009193 GNB3 GNB3 MAP2K1 MAP2K1 ATF4 ATF4 LOC105718736 LOC105718736 TGFBR1 TGFBR1 ADCY2 ADCY2 CREB3L1 CREB3L1 GNG8 GNG8 VEGFB VEGFB COL3A1 COL3A1 GNB2 GNB2 PRKACA PRKACA FBXO21 FBXO21 MAPK9 MAPK9 PRKACB PRKACB CSDE1 CSDE1 ENSANAP00000013693 ENSANAP00000013693 ENSANAP00000013747 ENSANAP00000013747 ENSANAP00000014288 ENSANAP00000014288 CREB3L2 CREB3L2 MAPK1 MAPK1 GNG11 GNG11 CREB1 CREB1 GNB4 GNB4 GNB5 GNB5 GNAI1 GNAI1 ENSANAP00000016577 ENSANAP00000016577 PRKCZ PRKCZ GNGT1 GNGT1 TGFBR2 TGFBR2 COL4A2 COL4A2 GNG7 GNG7 CEP152 CEP152 PIK3CA PIK3CA AKT1 AKT1 ENSANAP00000019599 ENSANAP00000019599 COL1A2 COL1A2 ADCY4 ADCY4 RLN3 RLN3 ENSANAP00000021185 ENSANAP00000021185 COL1A1 COL1A1 MMP1 MMP1 GNG3 GNG3 CREB3L3 CREB3L3 GNA15 GNA15 CREB3 CREB3 FOS FOS MMP2 MMP2 ENSANAP00000023918 ENSANAP00000023918 ADCY6 ADCY6 SHC3 SHC3 KRAS KRAS GNG13 GNG13 EDN1 EDN1 NFKBIA NFKBIA LOC105731947 LOC105731947 ADCY1 ADCY1 ENSANAP00000027046 ENSANAP00000027046 ADCY7 ADCY7 PIK3CD PIK3CD SMAD2 SMAD2 AKT3 AKT3 SOS1 SOS1 RAF1 RAF1 ADCY5 ADCY5 PLCB3 PLCB3 MMP9 MMP9 COL4A6 COL4A6 PIK3R1 PIK3R1 COL4A4 COL4A4 NFKB1 NFKB1 SRC SRC LOC105727567 LOC105727567 SHC2 SHC2 GNG2 GNG2 PRKCA PRKCA GNAI2 GNAI2 GNG14 GNG14 HRAS HRAS RXFP2 RXFP2 MAPK12 MAPK12 ADCY8 ADCY8 PLCB1 PLCB1 COL4A5 COL4A5 PLCB2 PLCB2 MAPK11 MAPK11 WDR78 WDR78 ADCY9 ADCY9 RELA RELA TGFB1 TGFB1 EGFR EGFR LOC105706136 LOC105706136 NOS3 NOS3 ARRB2 ARRB2 GNG12 GNG12 VEGFC VEGFC LOC105730743 LOC105730743 MAP2K4 MAP2K4 ATF6B ATF6B GNB1 GNB1 ARRB1 ARRB1 GNG5 GNG5 ATF2 ATF2 PIK3R3 PIK3R3 MAPK3 MAPK3 MFF MFF MAPK14 MAPK14 VEGFD VEGFD INSL5 INSL5 SHC4 SHC4 PIK3CB PIK3CB NOS2 NOS2 AKT2 AKT2 EDNRB EDNRB MMP13 MMP13 GRB2 GRB2 ENSANAP00000005262 ENSANAP00000005262 GNGT2 GNGT2 LOC105734475 LOC105734475 MAPK8 MAPK8 MAPK10 MAPK10 NOS1 NOS1 SHC1 SHC1 GNAI3 GNAI3 ADCY3 ADCY3 LOC105712010 LOC105712010 SOS2 SOS2 PTRHD1 PTRHD1 GNAO1 GNAO1 LOC105727565 LOC105727565 INSL3 INSL3 CREB5 CREB5 GNG4 GNG4 NRAS NRAS PLCB4 PLCB4 COL4A1 COL4A1 RXFP1 RXFP1 PIK3R2 PIK3R2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (412 aa)
ENSANAP00000008182Uncharacterized protein. (168 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (394 aa)
MAPK13Mitogen-activated protein kinase. (392 aa)
ENSANAP00000009193Uncharacterized protein. (290 aa)
GNB3G protein subunit beta 3. (340 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ATF4Activating transcription factor 4. (350 aa)
LOC105718736IlGF domain-containing protein. (169 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (205 aa)
COL3A1Collagen type III alpha 1 chain. (1465 aa)
GNB2G protein subunit beta 2. (383 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
FBXO21F-box protein 21. (628 aa)
MAPK9Mitogen-activated protein kinase 9. (442 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (358 aa)
CSDE1Cold shock domain containing E1. (843 aa)
ENSANAP00000013693Uncharacterized protein. (110 aa)
ENSANAP00000013747Uncharacterized protein. (107 aa)
ENSANAP00000014288Uncharacterized protein. (331 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (424 aa)
MAPK1Mitogen-activated protein kinase. (376 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
GNB4G protein subunit beta 4. (365 aa)
GNB5G protein subunit beta 5. (395 aa)
GNAI1G protein subunit alpha i1. (354 aa)
ENSANAP00000016577Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (63 aa)
PRKCZProtein kinase C. (594 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
COL4A2Collagen type IV alpha 2 chain. (1715 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CEP152Centrosomal protein 152. (1766 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (434 aa)
ENSANAP00000019599Uncharacterized protein. (318 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
RLN3Relaxin 3. (142 aa)
ENSANAP00000021185Uncharacterized protein. (269 aa)
COL1A1Collagen type I alpha 1 chain. (1453 aa)
MMP1Matrix metallopeptidase 1. (469 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (501 aa)
GNA15G protein subunit alpha 15. (374 aa)
CREB3cAMP responsive element binding protein 3. (371 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
ENSANAP00000023918Uncharacterized protein; Belongs to the protein kinase superfamily. (318 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1041 aa)
SHC3SHC adaptor protein 3. (598 aa)
KRASKRAS proto-oncogene, GTPase. (211 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
EDN1Endothelin 1. (212 aa)
NFKBIANFKB inhibitor alpha. (310 aa)
LOC105731947Uncharacterized protein. (348 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
ENSANAP00000027046Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1055 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1246 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1235 aa)
MMP9Matrix metallopeptidase 9. (703 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
COL4A4Collagen type IV alpha 4 chain. (1636 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
SRCTyrosine-protein kinase. (542 aa)
LOC105727567Uncharacterized protein. (247 aa)
SHC2SHC adaptor protein 2. (425 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
GNAI2G protein subunit alpha i2. (359 aa)
GNG14G protein gamma domain-containing protein. (68 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
RXFP2Relaxin family peptide receptor 2. (753 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
COL4A5Collagen type IV alpha 5 chain. (1715 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1170 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
WDR78WD repeat domain 78. (840 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
RELARELA proto-oncogene, NF-kB subunit. (540 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (378 aa)
EGFREpidermal growth factor receptor. (705 aa)
LOC105706136Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (411 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
ARRB2Arrestin beta 2. (460 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (424 aa)
LOC105730743Uncharacterized protein. (183 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (375 aa)
ATF6BActivating transcription factor 6 beta. (700 aa)
GNB1G protein subunit beta 1. (340 aa)
ARRB1Arrestin beta 1. (418 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ATF2Activating transcription factor 2. (287 aa)
PIK3R3Uncharacterized protein. (478 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
MFFMitochondrial fission factor. (353 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (356 aa)
INSL5Insulin like 5. (135 aa)
SHC4SHC adaptor protein 4. (628 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1225 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (442 aa)
MMP13Matrix metallopeptidase 13. (488 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ENSANAP00000005262Uncharacterized protein; Belongs to the protein kinase superfamily. (337 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (101 aa)
LOC105734475Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
MAPK8Mitogen-activated protein kinase. (387 aa)
MAPK10Mitogen-activated protein kinase. (533 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1393 aa)
SHC1SHC adaptor protein 1. (577 aa)
GNAI3Uncharacterized protein. (354 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
LOC105712010Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (143 aa)
GNAO1G protein subunit alpha o1. (354 aa)
LOC105727565GNAS complex locus. (1040 aa)
INSL3IlGF domain-containing protein. (131 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
NRASUncharacterized protein. (189 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
COL4A1Collagen type IV alpha 1 chain. (1340 aa)
RXFP1Relaxin family peptide receptor 1. (752 aa)
PIK3R2Uncharacterized protein. (640 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
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