(114 nodes) Parathyroid hormone synthesis, secretion and action network (Aotus nancymaae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	MMP25	Matrix metallopeptidase 25. (567 aa)
	MMP15	Matrix metallopeptidase 15. (597 aa)
	SOST	Sclerostin. (213 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
	MEF2C	Myocyte enhancer factor 2C. (490 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
	ATF2	Activating transcription factor 2. (287 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (158 aa)
	ARRB1	Arrestin beta 1. (418 aa)
	ATF6B	Activating transcription factor 6 beta. (700 aa)
	RXRB	Retinoid X receptor beta. (533 aa)
	ARRB2	Arrestin beta 2. (460 aa)
	EGFR	Epidermal growth factor receptor. (705 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1354 aa)
	PDE4B	Phosphodiesterase. (736 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1170 aa)
	BGLAP	Osteocalcin; Binds strongly to apatite and calcium. (100 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (618 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
	RUNX2	RUNX family transcription factor 2. (587 aa)
	NACA	NAC-A/B domain-containing protein. (2062 aa)
	ENSANAP00000033051	NAC-A/B domain-containing protein. (212 aa)
	GNAI2	G protein subunit alpha i2. (359 aa)
	NR4A2	Nuclear receptor subfamily 4 group A member 2. (598 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	LOC105727567	Uncharacterized protein. (247 aa)
	MEF2D	Myocyte enhancer factor 2D. (521 aa)
	GNA11	G protein subunit alpha 11. (359 aa)
	PDE4D	Phosphodiesterase. (748 aa)
	BCL2	BCL2 apoptosis regulator. (240 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1235 aa)
	CASR	Calcium sensing receptor. (1078 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1246 aa)
	RXRG	Retinoid X receptor gamma. (463 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
	MMP17	Matrix metallopeptidase 17. (594 aa)
	SP1	Sp1 transcription factor. (779 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
	GATA3	GATA binding protein 3. (409 aa)
	LOC105731947	Uncharacterized protein. (348 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (787 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1041 aa)
	ENSANAP00000023918	Uncharacterized protein; Belongs to the protein kinase superfamily. (318 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	CREB3	cAMP responsive element binding protein 3. (371 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (501 aa)
	KL	Klotho. (998 aa)
	SLC34A1	Solute carrier family 34 member 1. (676 aa)
	GNA12	G protein subunit alpha 12. (380 aa)
	VDR	Vitamin D receptor. (400 aa)
	CYP24A1	Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (514 aa)
	ITPR1	Uncharacterized protein. (1010 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	AKAP13	A-kinase anchoring protein 13. (2823 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	ENSANAP00000019599	Uncharacterized protein. (318 aa)
	GCM2	Glial cells missing transcription factor 2. (506 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1597 aa)
	PLD1	Phospholipase. (1091 aa)
	ENSANAP00000018110	Ion_trans domain-containing protein. (466 aa)
	PTH1R	Parathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
	SLC34A3	Solute carrier family 34 member 3. (598 aa)
	GNAI1	G protein subunit alpha i1. (354 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	MAPK1	Mitogen-activated protein kinase. (376 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (424 aa)
	ENSANAP00000014288	Uncharacterized protein. (331 aa)
	PDE4A	Phosphodiesterase. (877 aa)
	GNA13	G protein subunit alpha 13. (325 aa)
	ENSANAP00000013693	Uncharacterized protein. (110 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (317 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (358 aa)
	PTHLH	Parathyroid hormone like hormone. (209 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (519 aa)
	MMP24	Matrix metallopeptidase 24. (591 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1052 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	ATF4	Activating transcription factor 4. (350 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (698 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (546 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	MEF2A	Myocyte enhancer factor 2A. (506 aa)
	ENSANAP00000009193	Uncharacterized protein. (290 aa)
	RXRA	Retinoid X receptor alpha. (532 aa)
	PLD2	Phospholipase. (933 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (394 aa)
	FGFR1	Fibroblast growth factor receptor 1. (962 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1542 aa)
	RHOC	Ras homolog family member C. (193 aa)
	MMP13	Matrix metallopeptidase 13. (488 aa)
	ENSANAP00000005262	Uncharacterized protein; Belongs to the protein kinase superfamily. (337 aa)
	SLC34A2	Solute carrier family 34 member 2. (622 aa)
	GNAQ	G protein subunit alpha q. (359 aa)
	MMP16	Matrix metallopeptidase 16. (607 aa)
	PDE4C	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (684 aa)
	ARHGEF1	Rho guanine nucleotide exchange factor 1. (970 aa)
	GNAI3	Uncharacterized protein. (354 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
	PTRHD1	Peptidyl-tRNA hydrolase domain containing 1. (143 aa)
	GCM1	Glial cells missing transcription factor 1. (436 aa)
	LOC105727565	GNAS complex locus. (1040 aa)
	MAFB	MAF bZIP transcription factor B. (323 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
	ENSANAP00000001562	Uncharacterized protein. (85 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
	SLC9A3R1	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSANAP00000027030	ENSANAP00000011676	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.523
ADCY1	ADCY4	ENSANAP00000027030	ENSANAP00000020388	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.512
ADCY1	ADCY5	ENSANAP00000027030	ENSANAP00000028402	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.522
ADCY1	ADCY6	ENSANAP00000027030	ENSANAP00000024564	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.522
ADCY1	ADCY7	ENSANAP00000027030	ENSANAP00000027411	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.549
ADCY1	ADCY8	ENSANAP00000027030	ENSANAP00000033521	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.872
ADCY1	ADCY9	ENSANAP00000027030	ENSANAP00000036259	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.658
ADCY1	ENSANAP00000005262	ENSANAP00000027030	ENSANAP00000005262	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.494
ADCY1	ENSANAP00000009193	ENSANAP00000027030	ENSANAP00000009193	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.542
ADCY1	ENSANAP00000014288	ENSANAP00000027030	ENSANAP00000014288	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.494
ADCY1	ENSANAP00000019599	ENSANAP00000027030	ENSANAP00000019599	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.780
ADCY1	ENSANAP00000023918	ENSANAP00000027030	ENSANAP00000023918	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.494
ADCY1	GNAI1	ENSANAP00000027030	ENSANAP00000016314	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.888
ADCY1	GNAI2	ENSANAP00000027030	ENSANAP00000032476	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.886
ADCY1	GNAI3	ENSANAP00000027030	ENSANAP00000003554	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.542
ADCY1	LOC105727565	ENSANAP00000027030	ENSANAP00000002419	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.935
ADCY1	LOC105727567	ENSANAP00000027030	ENSANAP00000032049	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.869
ADCY1	LOC105731947	ENSANAP00000027030	ENSANAP00000026613	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.873
ADCY1	PDE4A	ENSANAP00000027030	ENSANAP00000014206	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.789
ADCY1	PDE4B	ENSANAP00000027030	ENSANAP00000035966	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.789