(65 nodes) Mineral absorption network (Aotus nancymaae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	LOC105721038	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (171 aa)
	ENSANAP00000040718	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (189 aa)
	ATP2B2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
	SLC39A4	Solute carrier family 39 member 4. (641 aa)
	TRPM7	Transient receptor potential cation channel subfamily M member 7. (1826 aa)
	SLC9A5	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (896 aa)
	ATOX1	Antioxidant 1 copper chaperone. (73 aa)
	ATP1A2	Sodium/potassium-transporting ATPase subunit alpha. (1026 aa)
	LTF	Lactotransferrin; Belongs to the transferrin family. (710 aa)
	CYBRD1	Cytochrome b reductase 1. (287 aa)
	TRPM6	Transient receptor potential cation channel subfamily M member 6. (2109 aa)
	SLC30A1	Solute carrier family 30 member 1. (507 aa)
	HMOX2	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (315 aa)
	LOC105709438	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (173 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1025 aa)
	SLC11A2	Solute carrier family 11 member 2. (590 aa)
	ENSANAP00000031370	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (235 aa)
	ATP1A1	Sodium/potassium-transporting ATPase subunit alpha. (1023 aa)
	ATP2B3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1216 aa)
	SLC8A2	Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (923 aa)
	ATP1B1	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
	FTH1	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
	CELSR3	Cadherin EGF LAG seven-pass G-type receptor 3; Belongs to the G-protein coupled receptor 2 family. (3319 aa)
	SLC9A3	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (794 aa)
	HMOX1	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
	LOC105723514	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (157 aa)
	ATP1B3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
	LOC105733485	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (137 aa)
	ENSANAP00000025969	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (62 aa)
	SLC6A19	Solute carrier family 6 member 19. (613 aa)
	LOC105726922	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (165 aa)
	SLC26A3	Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (756 aa)
	SLC8A1	Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
	CLCN2	Chloride channel protein. (877 aa)
	FTL	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (175 aa)
	STEAP2	STEAP2 metalloreductase. (490 aa)
	SLC34A1	Solute carrier family 34 member 1. (676 aa)
	VDR	Vitamin D receptor. (400 aa)
	ATP2B1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
	SLC5A1	Solute carrier family 5 member 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (663 aa)
	SLC40A1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (573 aa)
	SLC5A4	Solute carrier family 5 member 4; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (552 aa)
	SLC34A3	Solute carrier family 34 member 3. (598 aa)
	ENSANAP00000015612	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (152 aa)
	PGPEP1	Pyroglutamyl-peptidase I. (191 aa)
	HEPH	Hephaestin; Belongs to the multicopper oxidase family. (1198 aa)
	LOC105733285	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (178 aa)
	ATP7A	ATPase copper transporting alpha. (1500 aa)
	ATP1A3	Sodium/potassium-transporting ATPase subunit alpha. (1059 aa)
	SLC8A3	Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
	SLC31A1	Solute carrier family 31 member 1. (192 aa)
	STEAP1	Ferric oxidoreductase domain-containing protein. (339 aa)
	SLC26A9	Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (853 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (306 aa)
	S100G	Protein S100; Belongs to the S-100 family. (79 aa)
	ATP1B4	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
	LOC105714305	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (72 aa)
	ENSANAP00000000457	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (56 aa)
	TF	Uncharacterized protein; Belongs to the transferrin family. (699 aa)
	LOC105705290	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (168 aa)
	SLC26A6	Solute carrier family 26 member 6. (796 aa)
	ENSANAP00000002875	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (235 aa)
	ATP7B	ATPase copper transporting beta. (1463 aa)
	MT1E	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (81 aa)
	SLC34A2	Solute carrier family 34 member 2. (622 aa)

Your Current Organism:

Aotus nancymaae

NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATOX1	ATP7A	ENSANAP00000035676	ENSANAP00000011026	Antioxidant 1 copper chaperone.	ATPase copper transporting alpha.	0.975
ATOX1	ATP7B	ENSANAP00000035676	ENSANAP00000004474	Antioxidant 1 copper chaperone.	ATPase copper transporting beta.	0.971
ATOX1	CLCN2	ENSANAP00000035676	ENSANAP00000023963	Antioxidant 1 copper chaperone.	Chloride channel protein.	0.537
ATOX1	ENSANAP00000000457	ENSANAP00000035676	ENSANAP00000000457	Antioxidant 1 copper chaperone.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.550
ATOX1	LOC105714305	ENSANAP00000035676	ENSANAP00000000287	Antioxidant 1 copper chaperone.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.500
ATOX1	MT1E	ENSANAP00000035676	ENSANAP00000004598	Antioxidant 1 copper chaperone.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.608
ATOX1	SLC31A1	ENSANAP00000035676	ENSANAP00000009593	Antioxidant 1 copper chaperone.	Solute carrier family 31 member 1.	0.531
ATOX1	TRPM6	ENSANAP00000035676	ENSANAP00000033158	Antioxidant 1 copper chaperone.	Transient receptor potential cation channel subfamily M member 6.	0.567
ATOX1	TRPM7	ENSANAP00000035676	ENSANAP00000036222	Antioxidant 1 copper chaperone.	Transient receptor potential cation channel subfamily M member 7.	0.493
ATP1A1	ATP1A3	ENSANAP00000031156	ENSANAP00000010481	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.930
ATP1A1	ATP1B1	ENSANAP00000031156	ENSANAP00000030926	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.992
ATP1A1	ATP1B2	ENSANAP00000031156	ENSANAP00000006689	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.961
ATP1A1	ATP1B3	ENSANAP00000031156	ENSANAP00000027350	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.958
ATP1A1	ATP1B4	ENSANAP00000031156	ENSANAP00000006065	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.952
ATP1A1	ENSANAP00000002875	ENSANAP00000031156	ENSANAP00000002875	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.787
ATP1A1	ENSANAP00000025969	ENSANAP00000031156	ENSANAP00000025969	Sodium/potassium-transporting ATPase subunit alpha.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.983
ATP1A1	ENSANAP00000031370	ENSANAP00000031156	ENSANAP00000031370	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.787
ATP1A2	ATP1A3	ENSANAP00000034473	ENSANAP00000010481	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.930
ATP1A2	ATP1B1	ENSANAP00000034473	ENSANAP00000030926	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.992
ATP1A2	ATP1B2	ENSANAP00000034473	ENSANAP00000006689	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.961