STRINGSTRING
RPS6KB1 RPS6KB1 RALB RALB BBC3 BBC3 APC2 APC2 MAPK3 MAPK3 PIK3R3 PIK3R3 LOC105713293 LOC105713293 CDKN1A CDKN1A TCF7L2 TCF7L2 DDB2 DDB2 LOC105730743 LOC105730743 LOC105706136 LOC105706136 EGFR EGFR TGFB1 TGFB1 RAC1 RAC1 CASP9 CASP9 ARAF ARAF BIRC5 BIRC5 HRAS HRAS TCF7 TCF7 CTNNB1 CTNNB1 POLK POLK ENSANAP00000031715 ENSANAP00000031715 AREG AREG GADD45B GADD45B PIK3R1 PIK3R1 RAC2 RAC2 BCL2 BCL2 TGFB2 TGFB2 EREG EREG BAD BAD RAF1 RAF1 SOS1 SOS1 AKT3 AKT3 SMAD2 SMAD2 PIK3CD PIK3CD LOC105732154 LOC105732154 LEF1 LEF1 BRAF BRAF RALA RALA LOC105709634 LOC105709634 ENSANAP00000025464 ENSANAP00000025464 AXIN2 AXIN2 KRAS KRAS MTOR MTOR TGFA TGFA RPS6KB2 RPS6KB2 FOS FOS LOC110568101 LOC110568101 ENSANAP00000021185 ENSANAP00000021185 MLH1 MLH1 EGF EGF TP53 TP53 AKT1 AKT1 PIK3CA PIK3CA CCND1 CCND1 C7orf31 C7orf31 TGFBR2 TGFBR2 BAX BAX BAK1 BAK1 GSK3B GSK3B PPP1R14B PPP1R14B LOC105709745 LOC105709745 SMAD4 SMAD4 DCC DCC MAPK1 MAPK1 CASP3 CASP3 MSH2 MSH2 GADD45A GADD45A ENSANAP00000013747 ENSANAP00000013747 CSDE1 CSDE1 APPL1 APPL1 MYC MYC MAPK9 MAPK9 RALGDS RALGDS ENSANAP00000012107 ENSANAP00000012107 MSH6 MSH6 TGFBR1 TGFBR1 MAP2K1 MAP2K1 LOC105723072 LOC105723072 ENSANAP00000008706 ENSANAP00000008706 RAC3 RAC3 ENSANAP00000008182 ENSANAP00000008182 PMAIP1 PMAIP1 PIK3CB PIK3CB TCF7L1 TCF7L1 LOC105718674 LOC105718674 AKT2 AKT2 MSH3 MSH3 AXIN1 AXIN1 GADD45G GADD45G APC APC ENSANAP00000005921 ENSANAP00000005921 RHOC RHOC BCL2L11 BCL2L11 GRB2 GRB2 MAPK8 MAPK8 MAPK10 MAPK10 LOC105707993 LOC105707993 EPGN EPGN SOS2 SOS2 LOC105717114 LOC105717114 NRAS NRAS ENSANAP00000000642 ENSANAP00000000642 SMAD3 SMAD3 PIK3R2 PIK3R2 TGFB3 TGFB3 LOC105724646 LOC105724646
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RALBRAS like proto-oncogene B. (206 aa)
BBC3BCL2 binding component 3. (217 aa)
APC2APC regulator of WNT signaling pathway 2. (2273 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa)
PIK3R3Uncharacterized protein. (478 aa)
LOC105713293Uncharacterized protein. (328 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (158 aa)
TCF7L2Transcription factor 7 like 2. (618 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
LOC105730743Uncharacterized protein. (183 aa)
LOC105706136Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (411 aa)
EGFREpidermal growth factor receptor. (705 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (378 aa)
RAC1Uncharacterized protein. (208 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (396 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (618 aa)
BIRC5Baculoviral IAP repeat containing 5. (118 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TCF7Transcription factor 7. (477 aa)
CTNNB1Catenin beta 1. (781 aa)
POLKDNA polymerase kappa. (862 aa)
ENSANAP00000031715Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (100 aa)
AREGAmphiregulin. (252 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (175 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (723 aa)
RAC2Rac family small GTPase 2. (192 aa)
BCL2BCL2 apoptosis regulator. (240 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
EREGEpiregulin. (161 aa)
BADBCL2 associated agonist of cell death. (167 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1055 aa)
LOC105732154Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (787 aa)
RALARAS like proto-oncogene A. (206 aa)
LOC105709634Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (337 aa)
ENSANAP00000025464CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (249 aa)
AXIN2Axin 2. (843 aa)
KRASKRAS proto-oncogene, GTPase. (211 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
TGFATransforming growth factor alpha. (165 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
LOC110568101Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSANAP00000021185Uncharacterized protein. (269 aa)
MLH1DNA_mis_repair domain-containing protein. (757 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (434 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
C7orf31Chromosome 7 open reading frame 31. (589 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
BAXBCL2 associated X, apoptosis regulator. (193 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (146 aa)
LOC105709745Uncharacterized protein. (157 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
DCCDCC netrin 1 receptor. (1447 aa)
MAPK1Mitogen-activated protein kinase. (376 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (866 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
ENSANAP00000013747Uncharacterized protein. (107 aa)
CSDE1Cold shock domain containing E1. (843 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (709 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (463 aa)
MAPK9Mitogen-activated protein kinase 9. (442 aa)
RALGDSUncharacterized protein. (941 aa)
ENSANAP00000012107Uncharacterized protein. (193 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1347 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
LOC105723072DNA_mis_repair domain-containing protein. (626 aa)
ENSANAP00000008706Uncharacterized protein. (140 aa)
RAC3Rac family small GTPase 3. (192 aa)
ENSANAP00000008182Uncharacterized protein. (168 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
TCF7L1Transcription factor 7 like 1. (581 aa)
LOC105718674Uncharacterized protein. (43 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MSH3MutS homolog 3. (879 aa)
AXIN1Axin 1. (867 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
APCAPC regulator of WNT signaling pathway. (2861 aa)
ENSANAP00000005921Uncharacterized protein. (73 aa)
RHOCRas homolog family member C. (193 aa)
BCL2L11BCL2 like 11. (200 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK8Mitogen-activated protein kinase. (387 aa)
MAPK10Mitogen-activated protein kinase. (533 aa)
LOC105707993Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (451 aa)
EPGNEpithelial mitogen. (154 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
LOC105717114Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (210 aa)
NRASUncharacterized protein. (189 aa)
ENSANAP00000000642Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PIK3R2Uncharacterized protein. (640 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LOC105724646Uncharacterized protein. (151 aa)
Your Current Organism:
Aotus nancymaae
NCBI taxonomy Id: 37293
Other names: A. nancymaae, Aotus nancymai
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.