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| | CDK2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa) |
| | GALK2 | Galactokinase 2. (458 aa) |
| | ENSANAP00000033472 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (248 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | TCF7 | Transcription factor 7. (477 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | FGF17 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | POLK | DNA polymerase kappa. (862 aa) |
| | SHC2 | SHC adaptor protein 2. (425 aa) |
| | LOC105733239 | Uncharacterized protein. (916 aa) |
| | FGF3 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (238 aa) |
| | GADD45B | Growth arrest and DNA damage inducible beta. (175 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (723 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | BCL2 | BCL2 apoptosis regulator. (240 aa) |
| | WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa) |
| | WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | ENSANAP00000029484 | Uncharacterized protein. (182 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1095 aa) |
| | RXRG | Retinoid X receptor gamma. (463 aa) |
| | FGF8 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | FGFR2 | Fibroblast growth factor receptor. (840 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (467 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1055 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (414 aa) |
| | FGF20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (787 aa) |
| | FGF23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa) |
| | LOC105709634 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (337 aa) |
| | REG3G | Regenerating family member 3 gamma. (175 aa) |
| | AXIN2 | Axin 2. (843 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (211 aa) |
| | CTNNA1 | Catenin alpha 1. (945 aa) |
| | SHC3 | SHC adaptor protein 3. (598 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa) |
| | CTNNA2 | Catenin alpha 2. (953 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | FGF1 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa) |
| | WNT8B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | GAB1 | GRB2 associated binding protein 1. (751 aa) |
| | WNT7B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (274 aa) |
| | RPS6KB2 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa) |
| | FGF5 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (736 aa) |
| | ENSANAP00000023720 | Uncharacterized protein. (108 aa) |
| | E2F1 | E2F transcription factor 1. (397 aa) |
| | DVL1 | Dishevelled segment polarity protein 1. (750 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | FGF4 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa) |
| | FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | CDH1 | Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (855 aa) |
| | HGF | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa) |
| | LOC105721688 | Cyclin_C domain-containing protein; Belongs to the cyclin family. (384 aa) |
| | ENSANAP00000021185 | Uncharacterized protein. (269 aa) |
| | MLH1 | DNA_mis_repair domain-containing protein. (757 aa) |
| | FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (367 aa) |
| | WNT2 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa) |
| | REG4 | Regenerating family member 4. (158 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (434 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | CEP152 | Centrosomal protein 152. (1766 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1597 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | WNT9B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa) |
| | WNT10A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (193 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (376 aa) |
| | REG3A | Regenerating family member 3 alpha. (173 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1255 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) |
| | ENSANAP00000013747 | Uncharacterized protein. (107 aa) |
| | CSDE1 | Cold shock domain containing E1. (843 aa) |
| | WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (463 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1391 aa) |
| | JUP | Uncharacterized protein. (745 aa) |
| | FGF21 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa) |
| | RXRA | Retinoid X receptor alpha. (532 aa) |
| | LOC105723072 | DNA_mis_repair domain-containing protein. (626 aa) |
| | ENSANAP00000008182 | Uncharacterized protein. (168 aa) |
| | RB1 | RB transcriptional corepressor 1. (925 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa) |
| | TCF7L1 | Transcription factor 7 like 1. (581 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | CSNK1A1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (365 aa) |
| | FZD2 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa) |
| | AXIN1 | Axin 1. (867 aa) |
| | GADD45G | Growth arrest and DNA damage inducible gamma. (159 aa) |
| | APC | APC regulator of WNT signaling pathway. (2861 aa) |
| | FZD6 | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa) |
| | DVL3 | Dishevelled segment polarity protein 3. (724 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (217 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (543 aa) |
| | FZD9 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa) |
| | LOC105729166 | Uncharacterized protein. (734 aa) |
| | FGF22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (168 aa) |
| | CCNE1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (410 aa) |
| | SHC1 | SHC adaptor protein 1. (577 aa) |
| | LOC105707993 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (451 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | FZD10 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa) |
| | CDKN2B | Cyclin dependent kinase inhibitor 2B. (138 aa) |
| | LOC105717114 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (210 aa) |
| | CTNNA3 | Catenin alpha 3. (894 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa) |
| | CDH17 | Cadherin 17. (868 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa) |
| | NRAS | Uncharacterized protein. (189 aa) |
| | E2F3 | E2F transcription factor 3. (461 aa) |
| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | PIK3R2 | Uncharacterized protein. (640 aa) |
| | SHC4 | SHC adaptor protein 4. (628 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2273 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (355 aa) |
| | FGF2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (236 aa) |
| | PIK3R3 | Uncharacterized protein. (478 aa) |
| | LOC105713293 | Uncharacterized protein. (328 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (158 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (618 aa) |
| | RXRB | Retinoid X receptor beta. (533 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (427 aa) |
| | LOC105730743 | Uncharacterized protein. (183 aa) |
| | RARB | Retinoic acid receptor beta. (448 aa) |
| | LOC105706136 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (411 aa) |
| | WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | EGFR | Epidermal growth factor receptor. (705 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (378 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (205 aa) |
| | FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (618 aa) |
