(90 nodes) Ubiquitin-dependent ERAD pathway network (Malus domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DVH24_024551	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (276 aa)
	DVH24_031152	CDC48_2 domain-containing protein. (121 aa)
	DVH24_031153	ATPase_AAA_core domain-containing protein; Belongs to the AAA ATPase family. (94 aa)
	DVH24_028139	Uncharacterized protein. (570 aa)
	DVH24_037023	Uncharacterized protein. (1571 aa)
	DVH24_027718	UBIQUITIN_CONJUGAT_2 domain-containing protein. (268 aa)
	DVH24_031125	CDC48_N domain-containing protein. (214 aa)
	DVH24_031124	Uncharacterized protein. (473 aa)
	DVH24_031154	Uncharacterized protein; Belongs to the AAA ATPase family. (365 aa)
	DVH24_013423	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (1750 aa)
	DVH24_025213	Uncharacterized protein. (526 aa)
	DVH24_012049	Uncharacterized protein. (224 aa)
	DVH24_025502	J domain-containing protein. (403 aa)
	DVH24_029387	Uncharacterized protein. (89 aa)
	DVH24_013059	Ubiquitin-like domain-containing protein. (1216 aa)
	DVH24_029058	Ubiquitin-like domain-containing protein. (840 aa)
	DVH24_029356	Uncharacterized protein. (321 aa)
	DVH24_029388	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (211 aa)
	DVH24_023500	Uncharacterized protein. (683 aa)
	DVH24_039897	Uncharacterized protein. (544 aa)
	DVH24_039561	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (594 aa)
	DVH24_039701	Uncharacterized protein. (103 aa)
	DVH24_040031	Uncharacterized protein; Belongs to the heat shock protein 70 family. (667 aa)
	DVH24_042760	TPR_REGION domain-containing protein. (464 aa)
	DVH24_019359	UBA domain-containing protein. (285 aa)
	DVH24_039638	Uncharacterized protein. (819 aa)
	DVH24_041155	Uncharacterized protein. (547 aa)
	DVH24_040004	UBX domain-containing protein. (473 aa)
	DVH24_004664	Uncharacterized protein. (806 aa)
	DVH24_004774	Uncharacterized protein. (138 aa)
	DVH24_005187	UBA domain-containing protein. (406 aa)
	DVH24_036598	Uncharacterized protein. (422 aa)
	DVH24_003382	OTU domain-containing protein. (207 aa)
	DVH24_036514	Uncharacterized protein. (619 aa)
	DVH24_036932	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the calreticulin family. (694 aa)
	DVH24_005858	ABC transporter domain-containing protein. (1508 aa)
	DVH24_026896	Mannosyltransferase. (573 aa)
	DVH24_017002	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (243 aa)
	DVH24_017473	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (630 aa)
	DVH24_002553	Uncharacterized protein. (359 aa)
	DVH24_032927	Uncharacterized protein. (322 aa)
	DVH24_002545	Uncharacterized protein. (298 aa)
	DVH24_016928	AAA domain-containing protein; Belongs to the AAA ATPase family. (586 aa)
	DVH24_042420	AAA domain-containing protein; Belongs to the AAA ATPase family. (435 aa)
	DVH24_034254	RING-CH-type domain-containing protein. (1062 aa)
	DVH24_000536	UBIQUITIN_CONJUGAT_2 domain-containing protein. (458 aa)
	DVH24_032360	Uncharacterized protein. (1238 aa)
	DVH24_031988	Uncharacterized protein. (1416 aa)
	DVH24_033461	Uncharacterized protein; Belongs to the heat shock protein 70 family. (621 aa)
	DVH24_033460	Uncharacterized protein. (429 aa)
	DVH24_033459	Uncharacterized protein; Belongs to the heat shock protein 70 family. (601 aa)
	DVH24_013908	Mannosyltransferase. (452 aa)
	DVH24_007967	UBX domain-containing protein. (592 aa)
	DVH24_024548	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (260 aa)
	DVH24_008701	Uncharacterized protein; Belongs to the AAA ATPase family. (407 aa)
	DVH24_008761	Uncharacterized protein. (121 aa)
	DVH24_008283	Uncharacterized protein; Belongs to the heat shock protein 70 family. (731 aa)
	DVH24_008303	UBX domain-containing protein. (472 aa)
	DVH24_008412	Uncharacterized protein. (543 aa)
	DVH24_008767	Uncharacterized protein. (137 aa)
	DVH24_008766	Uncharacterized protein. (181 aa)
	DVH24_008705	Uncharacterized protein. (636 aa)
	DVH24_010551	Uncharacterized protein. (146 aa)
	DVH24_009145	Uncharacterized protein. (684 aa)
	DVH24_021351	Uncharacterized protein. (311 aa)
	DVH24_021360	Uncharacterized protein. (323 aa)
	DVH24_021412	AAA domain-containing protein; Belongs to the AAA ATPase family. (399 aa)
	DVH24_000984	Uncharacterized protein. (874 aa)
	DVH24_001265	UBX domain-containing protein. (601 aa)
	DVH24_011709	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (244 aa)
	DVH24_011296	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (630 aa)
	DVH24_014740	AAA domain-containing protein; Belongs to the AAA ATPase family. (400 aa)
	DVH24_001480	Uncharacterized protein. (806 aa)
	DVH24_021663	RING-CH-type domain-containing protein. (1110 aa)
	DVH24_030285	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the calreticulin family. (672 aa)
	DVH24_001056	Uncharacterized protein. (285 aa)
	DVH24_003778	Uncharacterized protein. (1945 aa)
	DVH24_015111	Calreticulin. (421 aa)
	DVH24_038911	Uncharacterized protein. (804 aa)
	DVH24_017681	Uncharacterized protein. (343 aa)
	DVH24_003040	Mannosyltransferase. (856 aa)
	DVH24_018042	Multifunctional fusion protein; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (391 aa)
	DVH24_017699	PRKCSH domain-containing protein. (290 aa)
	DVH24_017683	Uncharacterized protein. (126 aa)
	DVH24_018028	Uncharacterized protein. (427 aa)
	DVH24_017685	Ubiquitin-like domain-containing protein. (788 aa)
	DVH24_018217	CDC48_N domain-containing protein. (237 aa)
	DVH24_026049	Uncharacterized protein. (833 aa)
	DVH24_015413	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (258 aa)
	DVH24_014568	UBX domain-containing protein. (515 aa)

Your Current Organism:

Malus domestica

NCBI taxonomy Id: 3750
Other names: M. domestica, Malus communis, Malus communis Desf., Malus domestica Borkh., nom. cons. prop., Malus pumila auct., Malus pumila var. domestica, Malus pumila var. domestica (Borkh.) C.K.Schneid., Malus sylvestris var. domestica, Malus sylvestris var. domestica (Borkh.) Mansf., Malus x domestica, Pyrus malus, Pyrus malus L., apple, apple tree, cultivated apple

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DVH24_000536	DVH24_027718	A0A498J2W8	A0A498HEM9	UBIQUITIN_CONJUGAT_2 domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.901
DVH24_000984	DVH24_001265	A0A498JXX0	A0A498K093	Uncharacterized protein.	UBX domain-containing protein.	0.410
DVH24_000984	DVH24_001480	A0A498JXX0	A0A498K1C2	Uncharacterized protein.	Uncharacterized protein.	0.887
DVH24_000984	DVH24_004664	A0A498JXX0	A0A498IC09	Uncharacterized protein.	Uncharacterized protein.	0.887
DVH24_000984	DVH24_005858	A0A498JXX0	A0A498IN98	Uncharacterized protein.	ABC transporter domain-containing protein.	0.887
DVH24_000984	DVH24_007967	A0A498JXX0	A0A498JKU0	Uncharacterized protein.	UBX domain-containing protein.	0.410
DVH24_000984	DVH24_008303	A0A498JXX0	A0A498JPM1	Uncharacterized protein.	UBX domain-containing protein.	0.410
DVH24_000984	DVH24_008701	A0A498JXX0	A0A498JMU5	Uncharacterized protein.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.691
DVH24_000984	DVH24_008705	A0A498JXX0	A0A498JSI8	Uncharacterized protein.	Uncharacterized protein.	0.410
DVH24_000984	DVH24_014568	A0A498JXX0	A0A498KQH3	Uncharacterized protein.	UBX domain-containing protein.	0.497
DVH24_000984	DVH24_016928	A0A498JXX0	A0A498IUH9	Uncharacterized protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.688
DVH24_000984	DVH24_018217	A0A498JXX0	A0A498KK76	Uncharacterized protein.	CDC48_N domain-containing protein.	0.691
DVH24_000984	DVH24_031124	A0A498JXX0	A0A498HI44	Uncharacterized protein.	Uncharacterized protein.	0.691
DVH24_000984	DVH24_031125	A0A498JXX0	A0A498HG05	Uncharacterized protein.	CDC48_N domain-containing protein.	0.691
DVH24_000984	DVH24_031152	A0A498JXX0	A0A498HCQ1	Uncharacterized protein.	CDC48_2 domain-containing protein.	0.691
DVH24_000984	DVH24_031153	A0A498JXX0	A0A498HDG7	Uncharacterized protein.	ATPase_AAA_core domain-containing protein; Belongs to the AAA ATPase family.	0.691
DVH24_000984	DVH24_031154	A0A498JXX0	A0A498HI77	Uncharacterized protein.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.691
DVH24_000984	DVH24_031988	A0A498JXX0	A0A498J8B2	Uncharacterized protein.	Uncharacterized protein.	0.741
DVH24_000984	DVH24_037023	A0A498JXX0	A0A498HDW5	Uncharacterized protein.	Uncharacterized protein.	0.741
DVH24_000984	DVH24_038911	A0A498JXX0	A0A498KB98	Uncharacterized protein.	Uncharacterized protein.	0.887

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