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RD1_0025 RD1_0025 linX linX RD1_0200 RD1_0200 bktB bktB RD1_0205 RD1_0205 accD accD RD1_0415 RD1_0415 RD1_0476 RD1_0476 RD1_0507 RD1_0507 pct pct acdA acdA glcD glcD glcE glcE glcF glcF ald ald ald-2 ald-2 pta pta RD1_0838 RD1_0838 gabT gabT cpnE cpnE buk buk ptb ptb gabD gabD fadH fadH accA accA citE citE acsA acsA mclA mclA mtkA mtkA mtkB mtkB gyaR gyaR RD1_1179 RD1_1179 RD1_1204 RD1_1204 RD1_1281 RD1_1281 ibd2 ibd2 bhbD bhbD etfA etfA etfB etfB merA merA merA-2 merA-2 lpdA lpdA sucB sucB sucA sucA sucD sucD sucC sucC mdh mdh citE-2 citE-2 RD1_1623 RD1_1623 sdhC sdhC sdhD sdhD sdhA sdhA sdhB sdhB mutB mutB ccrA ccrA RD1_1673 RD1_1673 RD1_1679 RD1_1679 sgaA sgaA RD1_1753 RD1_1753 lipB lipB ttuD ttuD pccB pccB pccA pccA mutA mutA RD1_2064 RD1_2064 RD1_2065 RD1_2065 dxnH dxnH dxnG dxnG acdA-2 acdA-2 fumC fumC RD1_2290 RD1_2290 acsA-2 acsA-2 RD1_2337 RD1_2337 RD1_2338 RD1_2338 RD1_2502 RD1_2502 RD1_2529 RD1_2529 garR-2 garR-2 acnA acnA RD1_2621 RD1_2621 RD1_2623 RD1_2623 icd-2 icd-2 bdhA bdhA RD1_2751 RD1_2751 lipA lipA accB accB accC accC fabD fabD pdhB pdhB mmsA mmsA mmsB mmsB lpdA-2 lpdA-2 pdhA pdhA pdhB-2 pdhB-2 pdhC pdhC fabF fabF acpP acpP RD1_3039 RD1_3039 fabD-2 fabD-2 fabH fabH fabI-2 fabI-2 gltA gltA paaB paaB RD1_3230 RD1_3230 RD1_3261 RD1_3261 RD1_3294 RD1_3294 mvaB mvaB mccA mccA mccB mccB RD1_3299 RD1_3299 ivd ivd RD1_3321 RD1_3321 glcB glcB RD1_3328 RD1_3328 phbA phbA phbB phbB RD1_3404 RD1_3404 gyaR-2 gyaR-2 gph-2 gph-2 fabH-2 fabH-2 RD1_3495 RD1_3495 RD1_3522 RD1_3522 RD1_3670 RD1_3670 RD1_3675 RD1_3675 RD1_3756 RD1_3756 ackA ackA fabA fabA fabB fabB fabI fabI gcdH gcdH RD1_3969 RD1_3969 fadE fadE fadA fadA fadJ fadJ prpE prpE RD1_4098 RD1_4098 RD1_4241 RD1_4241 mclA-2 mclA-2 RD1_4244 RD1_4244 mtkA-2 mtkA-2 mtkB-2 mtkB-2 gyaR-3 gyaR-3
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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co-expression
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RD1_0025Thiolase, N-terminal domain; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
linX2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase, putative. (248 aa)
RD1_0200DNA-binding protein. (187 aa)
bktBBeta-ketothiolase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
RD1_0205enoyl-CoA hydratase/isomerase family protein; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (314 aa)
RD1_0415Putative dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (263 aa)
RD1_0476enoyl-CoA hydratase/isomerase family protein. (268 aa)
RD1_0507MaoC-like protein, putative. (148 aa)
pctPropionate CoA-transferase; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Belongs to the 3-oxoacid CoA-transferase family. (527 aa)
acdAacyl-CoA dehydrogenase. (387 aa)
glcDGlycolate oxidase, subunit GlcD. (484 aa)
glcEGlycolate oxidase, subunit GlcE. (381 aa)
glcFGlycolate oxidase, iron-sulfur subunit. (441 aa)
aldAldehyde dehydrogenase family protein, putative. (475 aa)
ald-2Aldehyde dehydrogenase family protein, putative; Belongs to the aldehyde dehydrogenase family. (780 aa)
ptaPhosphate acetyltransferase. (332 aa)
RD1_0838Transcription regulator, putative. (192 aa)
gabT4-aminobutyrate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (431 aa)
cpnE5-oxovalerate dehydrogenase, putative; Belongs to the aldehyde dehydrogenase family. (478 aa)
bukButyrate kinase; Belongs to the acetokinase family. (366 aa)
ptbPhosphate butyryltransferase, putative. (305 aa)
gabDSuccinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (492 aa)
fadH2,4-dienoyl-CoA reductase. (675 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (320 aa)
citECitrate lyase, beta subunit, putative; Belongs to the HpcH/HpaI aldolase family. (318 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (640 aa)
mclAmalyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (325 aa)
mtkAmalate-CoA ligase, beta subunit, putative; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (399 aa)
mtkBMalate-CoA ligase, alpha subunit, putative; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa)
gyaRGlyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (323 aa)
RD1_1179Conserved hypothetical protein. (134 aa)
RD1_12042-hydroxyacid dehydrogenase, putative. (310 aa)
RD1_1281Oxidoreductase, putative. (266 aa)
ibd2isobutyryl-CoA dehydrogenase. (561 aa)
bhbD3-hydroxybutyryl-CoA dehydrogenase. (291 aa)
etfAElectron transfer flavoprotein, alpha subunit. (309 aa)
etfBElectron transfer flavoprotein, beta subunit. (252 aa)
merAMercuric reductase. (243 aa)
merA-2Mercuric reductase. (492 aa)
lpdADihydrolipoamide dehydrogenase. (462 aa)
sucBDihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (498 aa)
sucAAlpha-ketoglutarate dehydrogenase. (986 aa)
sucDsuccinyl-CoA synthase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa)
sucCsuccinyl-CoA synthase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
citE-2Citrate lyase, beta subunit, putative; Belongs to the HpcH/HpaI aldolase family. (285 aa)
RD1_1623MaoC family protein. (344 aa)
sdhCSuccinate dehydrogenase, cytochrome b556 subunit. (127 aa)
sdhDSuc. (123 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (601 aa)
sdhBSuccinate dehydrogenase, iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa)
mutBmethylmalonyl-CoA mutase. (655 aa)
ccrAcrotonyl-CoA reductase, putative. (426 aa)
RD1_1673CAIB/BAIF family protein; Belongs to the CoA-transferase III family. (402 aa)
RD1_1679LAO/AO transport system kinase, putative. (329 aa)
sgaASerine--glyoxylate aminotransferase, putative. (410 aa)
RD1_1753enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (262 aa)
lipBLipoate-protein ligase B, putative; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (250 aa)
ttuDHydroxypyruvate reductase. (347 aa)
pccBpropionyl-CoA carboxylase, beta subunit; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), the enzyme catalyzing the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl- CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then tranfers the carboxyl group from carboxylated biotin to propionyl-CoA (Probable); Belongs to the AccD/PCCB family. (510 aa)
pccApropionyl-CoA carboxylase, alpha subunit. (681 aa)
mutAmethylmalonyl-CoA mutase. (709 aa)
RD1_2064Phosphotransferase, putative. (339 aa)
RD1_2065acyl-CoA dehydrogenase family protein. (411 aa)
dxnH3-oxoadipate CoA-succinyl transferase, beta subunit. (208 aa)
dxnG3-oxoadipate CoA-succinyl transferase, alpha subunit. (231 aa)
acdA-2acyl-CoA dehydrogenase. (382 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
RD1_2290Oxidoreductase, putative. (330 aa)
acsA-2Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa)
RD1_2337Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa)
RD1_2338Oxidoreductase, putative. (251 aa)
RD1_2502Oxidoreductase, putative; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (294 aa)
RD1_2529Haloacid dehalogenase-like hydrolase, putative. (230 aa)
garR-22-hydroxy-3-oxopropionate reductase, putative. (314 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (895 aa)
RD1_2621Acyl carrier protein. (101 aa)
RD1_2623Beta-ketoacyl synthase family protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (402 aa)
icd-2Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
bdhAD-beta-hydroxybutyrate dehydrogenase. (261 aa)
RD1_27513-hydroxyisobutyrate dehydrogenase, putative. (290 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (317 aa)
accBacetyl-CoA carboxylase, biotin carboxyl carrier protein, putative; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (160 aa)
accCacetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa)
fabDMalonyl CoA-acyl carrier protein transacylase, putative. (347 aa)
pdhBPyruvate dehydrogenase E1 component, beta subunit, putative. (729 aa)
mmsAMethylmalonate-semialdehyde dehydrogenase. (499 aa)
mmsB3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (641 aa)
lpdA-2Dihydrolipoamide dehydrogenase. (464 aa)
pdhAPyruvate dehydrogenase complex, E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (336 aa)
pdhB-2Pyruvate dehydrogenase complex, E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (459 aa)
pdhCPyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (431 aa)
fabF3-oxoacyl-(acyl carrier protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (419 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (77 aa)
RD1_3039Oxidoreductase, short chain dehydrogenase/reductase family; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa)
fabD-2Malonyl CoA-acyl carrier protein transacylase. (310 aa)
fabH3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (323 aa)
fabI-2Enoyl-(acyl-carrier-protein) reductase, putative. (291 aa)
gltACitrate synthase; Belongs to the citrate synthase family. (431 aa)
paaBenoyl-CoA hydratase/isomerase family protein; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
RD1_3230Ferredoxin/flavodoxin oxidoreductase family protein, putative. (1132 aa)
RD1_3261Oxidoreductase, putative. (259 aa)
RD1_3294enoyl-CoA hydratase/isomerase family protein. (260 aa)
mvaBhydroxymethylglutaryl-CoA lyase. (290 aa)
mccAmethylcrotonyl-CoA carboxylase, alpha subunit. (645 aa)
mccBmethylcrotonyl-CoA carboxylase, beta subunit. (534 aa)
RD1_3299Hypothetical protein. (106 aa)
ivdisovaleryl-CoA dehydrogenase. (387 aa)
RD1_3321Oxidoreductase, putative; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (252 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (715 aa)
RD1_3328Oxidoreductase, short chain dehydrogenase/reductase family. (246 aa)
phbAacetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
phbBacetoacetyl-CoA reductase, putative. (240 aa)
RD1_3404Electron transfer flavoprotein-ubiquinone oxidoreductase, putative; Accepts electrons from ETF and reduces ubiquinone. (549 aa)
gyaR-2Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
gph-2Phosphoglycolate phosphatase. (216 aa)
fabH-23-oxoacyl-[acyl-carrier-protein] synthase III, putative. (374 aa)
RD1_3495D-isomer specific 2-hydroxyacid dehydrogenase family protein. (317 aa)
RD1_3522MaoC-like protein, putative. (147 aa)
RD1_3670Pyridine nucleotide-disulfide oxidoreductase, putative. (485 aa)
RD1_3675Aminotransferase, putative. (1005 aa)
RD1_3756Short chain dehydrogenase, putative. (267 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (383 aa)
fabABeta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA, putative; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (248 aa)
fabB3-oxoacyl-(acyl-carrier-protein) synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (409 aa)
fabIEnoyl-(acyl-carrier-protein) reductase, putative. (263 aa)
gcdHglutaryl-CoA dehydrogenase. (407 aa)
RD1_3969acyl-CoA dehydrogenase family protein. (593 aa)
fadEacyl-CoA dehydrogenase. (382 aa)
fadAFatty acid oxidation complex beta subunit; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
fadJFatty acid oxidation complex alpha subunit, putative. (732 aa)
prpEpropionate--CoA ligase. (630 aa)
RD1_4098Oxidoreductase, putative. (1070 aa)
RD1_4241Hydroxypyruvate reductase, putative. (425 aa)
mclA-2malyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (325 aa)
RD1_4244Aminotransferase, putative. (413 aa)
mtkA-2malate-CoA ligase, beta subunit, putative; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (399 aa)
mtkB-2malate-CoA ligase, alpha subunit, putative; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (297 aa)
gyaR-3Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (330 aa)
Your Current Organism:
Roseobacter denitrificans
NCBI taxonomy Id: 375451
Other names: Erythrobacter sp. OCh114, R. denitrificans OCh 114, Roseobacter denitrificans ATCC 33942, Roseobacter denitrificans DSM 7001, Roseobacter denitrificans OCh 114, Roseobacter denitrificans str. OCh 114, Roseobacter denitrificans strain OCh 114, Roseobacter sp. OCh114
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