STRINGSTRING
soxA soxA soxD soxD soxB soxB RD1_0025 RD1_0025 gltB gltB gltD gltD dld dld dapE dapE dapE-2 dapE-2 dapD dapD serB serB serC serC serA serA bktB bktB idhA idhA fba fba RD1_0219 RD1_0219 RD1_0220 RD1_0220 iolD iolD RD1_0223 RD1_0223 RD1_0284 RD1_0284 bphF bphF asd asd fghA fghA RD1_0322 RD1_0322 accD accD gpmI gpmI cysQ cysQ tme tme hemD hemD iolB iolB RD1_0506 RD1_0506 RD1_0507 RD1_0507 pct pct glcD glcD glcE glcE glcF glcF RD1_0632 RD1_0632 ald ald dapB dapB ald-2 ald-2 kdgK kdgK RD1_0673 RD1_0673 RD1_0685 RD1_0685 paaK paaK dapA dapA dapF dapF pta pta gabT gabT hyuE hyuE gnl gnl RD1_0884 RD1_0884 flhA-2 flhA-2 RD1_0888 RD1_0888 moxF moxF RD1_0894 RD1_0894 gabD gabD mst mst RD1_0947 RD1_0947 dapA-2 dapA-2 dmsC dmsC RD1_0974 RD1_0974 phsA phsA accA accA citE citE pyk pyk rpe rpe acsA acsA RD1_1128 RD1_1128 cysE cysE RD1_1131 RD1_1131 mclA mclA mtkA mtkA mtkB mtkB gyaR gyaR glyA glyA RD1_1179 RD1_1179 RD1_1204 RD1_1204 gltX gltX hemC hemC RD1_1344 RD1_1344 RD1_1348 RD1_1348 ibd2 ibd2 pckA pckA bhbD bhbD RD1_1495 RD1_1495 RD1_1496 RD1_1496 RD1_1497 RD1_1497 soxX soxX soxY soxY soxZ soxZ soxA-2 soxA-2 soxB-2 soxB-2 soxC soxC soxD-2 soxD-2 RD1_1529 RD1_1529 RD1_1534 RD1_1534 nosZ nosZ norB norB norC norC nirS nirS nirE nirE lysA lysA lpdA lpdA sucB sucB sucA sucA sucD sucD sucC sucC mdh mdh citE-2 citE-2 RD1_1623 RD1_1623 sdhC sdhC sdhD sdhD sdhA sdhA sdhB sdhB mutB mutB ccrA ccrA argD argD sgaA sgaA metF metF gill gill soxB-4 soxB-4 soxD-4 soxD-4 soxA-4 soxA-4 RD1_1892 RD1_1892 RD1_1894 RD1_1894 nthA nthA nthB nthB rpiA rpiA ppdK ppdK ttuD ttuD pccB pccB pccA pccA mutA mutA RD1_2049 RD1_2049 tal tal folD folD thrC thrC RD1_2157 RD1_2157 ipuC ipuC icd icd fda fda fumC fumC cysB cysB RD1_2308 RD1_2308 acsA-2 acsA-2 pobA pobA RD1_2337 RD1_2337 gap gap RD1_2421 RD1_2421 narG narG narH narH narI narI gdhA gdhA RD1_2530 RD1_2530 glpX glpX hom hom acnA acnA glnA glnA icd-2 icd-2 pgi pgi pgl pgl zwf zwf hemB hemB RD1_2777 RD1_2777 RD1_2791 RD1_2791 dehH1 dehH1 accB accB accC accC pgm pgm eda eda edd edd gap-2 gap-2 sgaA-2 sgaA-2 fdhI fdhI fdhB fdhB fdhA fdhA cysK cysK tpiA tpiA cysG cysG cysI cysI cysH cysH tktA tktA gap-3 gap-3 lpdA-2 lpdA-2 pgk pgk pdhA pdhA pdhB-2 pdhB-2 pdhC pdhC cysE-2 cysE-2 metF-2 metF-2 RD1_3084 RD1_3084 galM galM eno eno RD1_3188 RD1_3188 pdxH pdxH gltX-2 gltX-2 gltA gltA paaB paaB RD1_3274 RD1_3274 glcB glcB pyc pyc phbA phbA phbB phbB ectC ectC gyaR-2 gyaR-2 RD1_3471 RD1_3471 RD1_3474 RD1_3474 RD1_3475 RD1_3475 RD1_3495 RD1_3495 RD1_3522 RD1_3522 ltaE ltaE prs prs fucA fucA serA-2 serA-2 hmgA hmgA maiA maiA fahA fahA dmsA dmsA RD1_3670 RD1_3670 RD1_3674 RD1_3674 gnl-2 gnl-2 RD1_3762 RD1_3762 RD1_3763 RD1_3763 xylA-2 xylA-2 pcaC pcaC pcaH pcaH pcaG pcaG glk glk ureA ureA ureB ureB ureC ureC flhA-3 flhA-3 RD1_3812 RD1_3812 bcpC bcpC lldD-2 lldD-2 cobA cobA ackA ackA RD1_3872 RD1_3872 deh deh pcaD pcaD pcaB pcaB gcdH gcdH fadA fadA fadJ fadJ RD1_3988 RD1_3988 glyA-2 glyA-2 xdhA xdhA xdhB xdhB tmd tmd RD1_4150 RD1_4150 cysG-2 cysG-2 nasA nasA nirD-2 nirD-2 nirB nirB fdhB-2 fdhB-2 fdhA-2 fdhA-2 fhs fhs folD-2 folD-2 folD-3 folD-3 RD1_4241 RD1_4241 mclA-2 mclA-2 RD1_4244 RD1_4244 mtkA-2 mtkA-2 mtkB-2 mtkB-2 gyaR-3 gyaR-3 ppc ppc RD1_4251 RD1_4251 RD1_4252 RD1_4252 RD1_4253 RD1_4253
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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soxASarcosine oxidase, alpha subunit; Belongs to the GcvT family. (983 aa)
soxDSarcosine oxidase, delta subunit. (95 aa)
soxBSarcosine oxidase, beta subunit. (416 aa)
RD1_0025Thiolase, N-terminal domain; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
gltBGlutamate synthase, large subunit. (1509 aa)
gltDGlutamate synthase, small subunit. (477 aa)
dldD-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (573 aa)
dapESuccinyl-diaminopimelate desuccinylase. (429 aa)
dapE-2Putative succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (381 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (275 aa)
serBPhosphoserine phosphatase, putative. (291 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (387 aa)
serAD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (531 aa)
bktBBeta-ketothiolase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
idhAMyo-inositol dehydrogenase. (331 aa)
fbaFructose-bisphosphate aldolase, putative. (282 aa)
RD1_0219Conserved hypothetical protein. (280 aa)
RD1_0220pfkB family kinase, putative. (324 aa)
iolDAcetolactate synthase; Belongs to the TPP enzyme family. (621 aa)
RD1_0223Conserved hypothetical protein. (298 aa)
RD1_0284Oxidoreductase, putative. (479 aa)
bphF4-hydroxy-2-oxovalerate aldolase; Belongs to the HpcH/HpaI aldolase family. (256 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa)
fghAS-formylglutathione hydrolase, putative; Serine hydrolase involved in the detoxification of formaldehyde. (276 aa)
RD1_0322Hydrolase, putative. (210 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (314 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (505 aa)
cysQ3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (266 aa)
tmeNADP-dependent malic enzyme. (751 aa)
hemDuroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (234 aa)
iolBMyo-inositol catabolism protein IolB, putative. (270 aa)
RD1_0506Oxidoreductase, putative. (338 aa)
RD1_0507MaoC-like protein, putative. (148 aa)
pctPropionate CoA-transferase; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Belongs to the 3-oxoacid CoA-transferase family. (527 aa)
glcDGlycolate oxidase, subunit GlcD. (484 aa)
glcEGlycolate oxidase, subunit GlcE. (381 aa)
glcFGlycolate oxidase, iron-sulfur subunit. (441 aa)
RD1_0632Flavin-containing monooxygenase. (466 aa)
aldAldehyde dehydrogenase family protein, putative. (475 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (272 aa)
ald-2Aldehyde dehydrogenase family protein, putative; Belongs to the aldehyde dehydrogenase family. (780 aa)
kdgK2-dehydro-3-deoxygluconokinase. (293 aa)
RD1_0673phytanoyl-CoA dioxygenase family protein. (292 aa)
RD1_0685Oxidoreductase, putative. (253 aa)
paaKphenylacetate-CoA ligase, putative. (411 aa)
dapADihydrodipicolinate synthase, putative; Belongs to the DapA family. (289 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (280 aa)
ptaPhosphate acetyltransferase. (332 aa)
gabT4-aminobutyrate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (431 aa)
hyuEHydantoin racemase. (227 aa)
gnlGluconolactonase, putative. (305 aa)
RD1_0884Conserved hypothetical protein. (270 aa)
flhA-2Glutathione-dependent formaldehyde dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (370 aa)
RD1_0888S-formylglutathione hydrolase, putative; Serine hydrolase involved in the detoxification of formaldehyde. (274 aa)
moxFMethanol dehydrogenase, large subunit. (600 aa)
RD1_0894Conserved hypothetical protein. (270 aa)
gabDSuccinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (492 aa)
mst3-mercaptopyruvate sulfurtransferase. (284 aa)
RD1_0947Pyridine nucleotide-disulphide oxidoreductase, putative. (402 aa)
dapA-2Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (291 aa)
dmsCAnaerobic dimethyl sulfoxide reductase, C subunit, putative. (290 aa)
RD1_09744Fe-4S binding domain protein. (252 aa)
phsAThiosulfate reductase, putative; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (939 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (320 aa)
citECitrate lyase, beta subunit, putative; Belongs to the HpcH/HpaI aldolase family. (318 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (482 aa)
rpeRibulose-5-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (230 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (640 aa)
RD1_1128Conserved hypothetical protein. (280 aa)
cysESerine acetyltransferase. (268 aa)
RD1_1131Tautomerase, putative; Belongs to the 4-oxalocrotonate tautomerase family. (73 aa)
mclAmalyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (325 aa)
mtkAmalate-CoA ligase, beta subunit, putative; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (399 aa)
mtkBMalate-CoA ligase, alpha subunit, putative; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa)
gyaRGlyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (323 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (429 aa)
RD1_1179Conserved hypothetical protein. (134 aa)
RD1_12042-hydroxyacid dehydrogenase, putative. (310 aa)
gltXglutamyl-tRNA synthetase, putative; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (441 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (314 aa)
RD1_1344Trimethylamine methyltransferase, putative; Belongs to the trimethylamine methyltransferase family. (513 aa)
RD1_1348Fumarylacetoacetate hydrolase, putative. (227 aa)
ibd2isobutyryl-CoA dehydrogenase. (561 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (532 aa)
bhbD3-hydroxybutyryl-CoA dehydrogenase. (291 aa)
RD1_1495Tryptophan monooxygenase, putative. (549 aa)
RD1_1496Hydrolase, putative. (261 aa)
RD1_1497Glutamine synthetase, putative. (435 aa)
soxXMonoheme cytochrome c SoxX. (157 aa)
soxYSulfur oxidation Y protein. (138 aa)
soxZSulfur oxidation Z protein. (110 aa)
soxA-2Diheme cytochrome c SoxA. (281 aa)
soxB-2Sulfur oxidation B protein; Belongs to the 5'-nucleotidase family. (567 aa)
soxCSulfite dehydrogenase SoxC protein. (428 aa)
soxD-2Diheme cytochrome c SoxD. (345 aa)
RD1_1529Amidohydrolase family protein. (393 aa)
RD1_1534Conserved hypothetical protein. (496 aa)
nosZNitrous-oxide reductase. (637 aa)
norBNitric-oxide reductase subunit B; Belongs to the heme-copper respiratory oxidase family. (456 aa)
norCNorC-like protein. (150 aa)
nirSNitrite reductase. (565 aa)
nirEuroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (263 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (421 aa)
lpdADihydrolipoamide dehydrogenase. (462 aa)
sucBDihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (498 aa)
sucAAlpha-ketoglutarate dehydrogenase. (986 aa)
sucDsuccinyl-CoA synthase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa)
sucCsuccinyl-CoA synthase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
citE-2Citrate lyase, beta subunit, putative; Belongs to the HpcH/HpaI aldolase family. (285 aa)
RD1_1623MaoC family protein. (344 aa)
sdhCSuccinate dehydrogenase, cytochrome b556 subunit. (127 aa)
sdhDSuc. (123 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (601 aa)
sdhBSuccinate dehydrogenase, iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa)
mutBmethylmalonyl-CoA mutase. (655 aa)
ccrAcrotonyl-CoA reductase, putative. (426 aa)
argDAcetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (391 aa)
sgaASerine--glyoxylate aminotransferase, putative. (410 aa)
metF5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (289 aa)
gillGlutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (477 aa)
soxB-4Sarcosine oxidase, beta subunit. (417 aa)
soxD-4Sarcosine oxidase, delta subunit. (89 aa)
soxA-4Sarcosine oxidase, alpha subunit; Belongs to the GcvT family. (975 aa)
RD1_1892Glutamine synthetase, putative. (452 aa)
RD1_1894Glutamine synthetase, putative. (444 aa)
nthANitrile hydratase, alpha subunit. (210 aa)
nthBNitrile hydratase, beta subunit; NHase catalyzes the hydration of various nitrile compounds to the corresponding amides; Belongs to the nitrile hydratase subunit beta family. (224 aa)
rpiARibose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (262 aa)
ppdKPyruvate, phosphate dikinase. (845 aa)
ttuDHydroxypyruvate reductase. (347 aa)
pccBpropionyl-CoA carboxylase, beta subunit; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), the enzyme catalyzing the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl- CoA/(S)-methylmalonyl-CoA. Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then tranfers the carboxyl group from carboxylated biotin to propionyl-CoA (Probable); Belongs to the AccD/PCCB family. (510 aa)
pccApropionyl-CoA carboxylase, alpha subunit. (681 aa)
mutAmethylmalonyl-CoA mutase. (709 aa)
RD1_2049malate/L-lactate dehydrogenase, putative; Belongs to the LDH2/MDH2 oxidoreductase family. (331 aa)
talTransaldolase, putative; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa)
folDFolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (300 aa)
thrCThreonine synthase. (460 aa)
RD1_2157Aspartate kinase; Belongs to the aspartokinase family. (412 aa)
ipuCGamma-glutamylisopropylamide synthetase, putative; Belongs to the glutamine synthetase family. (454 aa)
icdIsocitrate dehydrogenase, NADP-dependent; Belongs to the monomeric-type IDH family. (740 aa)
fdaFructose-bisphosphate aldolase, class I. (290 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
cysBCysteine synthase. (345 aa)
RD1_2308Oxidoreductase, putative. (366 aa)
acsA-2Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa)
pobAP-hydroxybenzoate hydroxylase. (391 aa)
RD1_2337Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
RD1_2421Polysaccharide deacetylase family protein, putative. (315 aa)
narGNitrate reductase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1246 aa)
narHNitrate reductase, beta subunit. (506 aa)
narINitrate reductase, gamma subunit. (264 aa)
gdhAGlutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (449 aa)
RD1_2530Trimethylamine methyltransferase family protein; Belongs to the trimethylamine methyltransferase family. (520 aa)
glpXFructose-1,6-bisphosphatase, class II. (324 aa)
homHomoserine dehydrogenase. (428 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (895 aa)
glnAGlutamine synthetase, type I. (467 aa)
icd-2Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
pgiGlucose-6-phosphate isomerase. (530 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (223 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (487 aa)
hemBDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (332 aa)
RD1_2777Trimethylamine methyltransferase family protein; Belongs to the trimethylamine methyltransferase family. (527 aa)
RD1_2791Monooxygenase, putative. (386 aa)
dehH1Haloacetate dehalogenase H-1, putative. (290 aa)
accBacetyl-CoA carboxylase, biotin carboxyl carrier protein, putative; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (160 aa)
accCacetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa)
pgmPhosphoglucomutase. (543 aa)
edaKHG/KDPG aldolase. (213 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (601 aa)
gap-2Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
sgaA-2Serine--glyoxylate aminotransferase. (396 aa)
fdhIFormate dehydrogenase, gamma subunit, putative. (396 aa)
fdhBFormate dehydrogenase Fe-S subunit. (198 aa)
fdhAFormate dehydrogenase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (960 aa)
cysKO-acetylserine sulfhydrylase. (359 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa)
cysGSiroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (475 aa)
cysISulfite reductase. (554 aa)
cysHPhosophoadenylyl-sulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (253 aa)
tktATransketolase; Belongs to the transketolase family. (681 aa)
gap-3Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
lpdA-2Dihydrolipoamide dehydrogenase. (464 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (395 aa)
pdhAPyruvate dehydrogenase complex, E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (336 aa)
pdhB-2Pyruvate dehydrogenase complex, E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (459 aa)
pdhCPyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (431 aa)
cysE-2Serine acetyltransferase. (273 aa)
metF-25,10-methylenetetrahydrofolate reductase, putative. (327 aa)
RD1_3084Conserved hypothetical protein. (424 aa)
galMAldose 1-epimerase, putative. (322 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (424 aa)
RD1_3188Trimethylamine methyltransferase family protein; Belongs to the trimethylamine methyltransferase family. (512 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (201 aa)
gltX-2glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (466 aa)
gltACitrate synthase; Belongs to the citrate synthase family. (431 aa)
paaBenoyl-CoA hydratase/isomerase family protein; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
RD1_3274Carboxymuconolactone decarboxylase. (138 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (715 aa)
pycPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1146 aa)
phbAacetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
phbBacetoacetyl-CoA reductase, putative. (240 aa)
ectCEctoine synthase, putative. (128 aa)
gyaR-2Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
RD1_3471Asp/Glu/Hydantoin racemase family protein, putative. (265 aa)
RD1_3474Peptidase, M24 family protein, putative. (391 aa)
RD1_3475Conserved hypothetical protein. (331 aa)
RD1_3495D-isomer specific 2-hydroxyacid dehydrogenase family protein. (317 aa)
RD1_3522MaoC-like protein, putative. (147 aa)
ltaELow-specificity L-threonine aldolase. (345 aa)
prsRibose-phosphate pyrophosphokinase putative; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (339 aa)
fucAL-fuculose phosphate aldolase. (217 aa)
serA-2D-3-phosphoglycerate dehydrogenase, putative; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (346 aa)
hmgAHomogentisate 1,2-dioxygenase. (449 aa)
maiAMaleylacetoacetate isomerase. (211 aa)
fahAFumarylacetoacetase. (416 aa)
dmsADimethyl sulfoxide reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (890 aa)
RD1_3670Pyridine nucleotide-disulfide oxidoreductase, putative. (485 aa)
RD1_3674Pyridoxal-phosphate dependent enzyme. (347 aa)
gnl-2Gluconolactonase, putative. (310 aa)
RD1_3762Oxidoreductase, putative. (342 aa)
RD1_3763Conserved hypothetical protein. (280 aa)
xylA-2Xylose isomerase, putative. (328 aa)
pcaC4-carboxymuconolactone decarboxylase. (127 aa)
pcaHProtocatechuate 3,4-dioxygenase, beta subunit. (240 aa)
pcaGProtocatechuate 3,4-dioxygenase, alpha subunit. (195 aa)
glkGlucokinase, putative; Belongs to the bacterial glucokinase family. (315 aa)
ureAUrease gamma subunit; Belongs to the urease gamma subunit family. (100 aa)
ureBUrease beta subunit; Belongs to the urease beta subunit family. (101 aa)
ureCUrease alpha subunit; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family. (569 aa)
flhA-3Glutathione-dependent formaldehyde dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (370 aa)
RD1_3812Decarboxylase, putative. (168 aa)
bcpC3-phosphonopyruvate decarboxylase, putative. (184 aa)
lldD-2L-lactate dehydrogenase (Cytochrome), putative. (367 aa)
cobAuroporphyrin-III C-methyltransferase, putative. (239 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (383 aa)
RD1_3872Oxidoreductase, putative; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa)
deh(S)-2-haloacid dehalogenase. (228 aa)
pcaD3-oxoadipate enol-lactonase, putative. (267 aa)
pcaB3-carboxy-cis,cis-muconate cycloisomerase, putative. (443 aa)
gcdHglutaryl-CoA dehydrogenase. (407 aa)
fadAFatty acid oxidation complex beta subunit; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
fadJFatty acid oxidation complex alpha subunit, putative. (732 aa)
RD1_3988Coenzyme F420 hydrogenase, beta subunit, putative. (402 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
xdhAXanthine dehydrogenase, A subunit. (457 aa)
xdhBXanthine dehydrogenase, B subunit. (765 aa)
tmdTrimethylamine dehydrogenase. (468 aa)
RD1_4150Conserved hypothetical protein; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (117 aa)
cysG-2Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (465 aa)
nasANitrate reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (858 aa)
nirD-2Assimilatory nitrite reductase, small subunit. (111 aa)
nirBAssimilatory nitrite reductase, large subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (808 aa)
fdhB-2Formate dehydrogenase, beta subunit. (560 aa)
fdhA-2Formate dehydrogenase, alpha subunit. (925 aa)
fhsFormate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (558 aa)
folD-2FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (300 aa)
folD-3FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (290 aa)
RD1_4241Hydroxypyruvate reductase, putative. (425 aa)
mclA-2malyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (325 aa)
RD1_4244Aminotransferase, putative. (413 aa)
mtkA-2malate-CoA ligase, beta subunit, putative; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (399 aa)
mtkB-2malate-CoA ligase, alpha subunit, putative; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (297 aa)
gyaR-3Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (330 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (871 aa)
RD1_4251Glutamate synthase family protein, putative; Belongs to the glutamate synthase family. (446 aa)
RD1_4252FwdC/FmdC family protein. (227 aa)
RD1_4253Glutamine amidotransferase, class II putative. (309 aa)
Your Current Organism:
Roseobacter denitrificans
NCBI taxonomy Id: 375451
Other names: Erythrobacter sp. OCh114, R. denitrificans OCh 114, Roseobacter denitrificans ATCC 33942, Roseobacter denitrificans DSM 7001, Roseobacter denitrificans OCh 114, Roseobacter denitrificans str. OCh 114, Roseobacter denitrificans strain OCh 114, Roseobacter sp. OCh114
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