STRINGSTRING
Fjoh_0020 Fjoh_0020 Fjoh_0048 Fjoh_0048 Fjoh_0049 Fjoh_0049 lipA lipA Fjoh_0228 Fjoh_0228 folD folD Fjoh_0367 Fjoh_0367 eno eno gcvP gcvP fbp fbp Fjoh_0664 Fjoh_0664 Fjoh_0675 Fjoh_0675 Fjoh_0676 Fjoh_0676 Fjoh_0677 Fjoh_0677 Fjoh_0708 Fjoh_0708 pgi pgi Fjoh_0755 Fjoh_0755 glmS glmS Fjoh_0881 Fjoh_0881 fda fda pgk pgk Fjoh_1019 Fjoh_1019 Fjoh_1126 Fjoh_1126 Fjoh_1141 Fjoh_1141 Fjoh_1225 Fjoh_1225 Fjoh_1255 Fjoh_1255 kgd kgd Fjoh_1303 Fjoh_1303 pckA pckA Fjoh_1432 Fjoh_1432 Fjoh_1463 Fjoh_1463 Fjoh_1475 Fjoh_1475 Fjoh_1552 Fjoh_1552 pdhA pdhA Fjoh_1651 Fjoh_1651 gcvH gcvH Fjoh_1656 Fjoh_1656 gpmI gpmI lipB lipB Fjoh_1951 Fjoh_1951 Fjoh_1952 Fjoh_1952 tal tal Fjoh_2129 Fjoh_2129 Fjoh_2133 Fjoh_2133 Fjoh_2160 Fjoh_2160 Fjoh_2161 Fjoh_2161 sucC sucC Fjoh_2181 Fjoh_2181 mdh mdh Fjoh_2271 Fjoh_2271 purU purU Fjoh_2344 Fjoh_2344 Fjoh_2345 Fjoh_2345 Fjoh_2409 Fjoh_2409 mqo mqo gcvT gcvT Fjoh_2638 Fjoh_2638 Fjoh_2806 Fjoh_2806 Fjoh_2840 Fjoh_2840 Fjoh_2859 Fjoh_2859 sucD sucD Fjoh_2967 Fjoh_2967 Fjoh_3293 Fjoh_3293 Fjoh_3325 Fjoh_3325 Fjoh_3326 Fjoh_3326 glyA glyA tpiA tpiA ackA ackA Fjoh_3529 Fjoh_3529 Fjoh_3835 Fjoh_3835 Fjoh_3836 Fjoh_3836 Fjoh_4167 Fjoh_4167 Fjoh_4210 Fjoh_4210 Fjoh_4211 Fjoh_4211 Fjoh_4212 Fjoh_4212 Fjoh_4244 Fjoh_4244 Fjoh_4334 Fjoh_4334 gcvH-2 gcvH-2 gcvT-2 gcvT-2 Fjoh_4452 Fjoh_4452 Fjoh_4512 Fjoh_4512 tal-2 tal-2 Fjoh_4590 Fjoh_4590 pfkA pfkA Fjoh_4676 Fjoh_4676 Fjoh_4713 Fjoh_4713 fumC fumC Fjoh_4811 Fjoh_4811 Fjoh_4869 Fjoh_4869 Fjoh_4988 Fjoh_4988
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene neighborhood
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Your Input:
Fjoh_0020TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (482 aa)
Fjoh_0048PFAM: Transketolase domain protein. (282 aa)
Fjoh_0049PFAM: Transketolase, central region; Transketolase domain protein. (317 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (288 aa)
Fjoh_0228TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (295 aa)
Fjoh_0367TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. (425 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (949 aa)
fbpPFAM: Inositol phosphatase/fructose-1,6-bisphosphatase. (334 aa)
Fjoh_0664PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase. (255 aa)
Fjoh_0675Succinate dehydrogenase/fumarate reductase iron-sulfur subunit; PFAM: ferredoxin; 4Fe-4S ferredoxin, iron-sulfur binding domain protein. (248 aa)
Fjoh_0676TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein. (666 aa)
Fjoh_0677TIGRFAM: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family. (221 aa)
Fjoh_0708Glutamate dehydrogenase (NADP(+)); PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (447 aa)
pgiPFAM: phosphoglucose isomerase (PGI); Belongs to the GPI family. (547 aa)
Fjoh_0755TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; Belongs to the ribose-phosphate pyrophosphokinase family. (275 aa)
glmSGlutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (616 aa)
Fjoh_0881Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (534 aa)
fdaPFAM: fructose-bisphosphate aldolase, class-I. (298 aa)
pgkPFAM: phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (395 aa)
Fjoh_1019TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase. (143 aa)
Fjoh_1126TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase. (313 aa)
Fjoh_1141PFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa)
Fjoh_1225PFAM: aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (517 aa)
Fjoh_12552-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (415 aa)
kgdTIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: dehydrogenase, E1 component; Transketolase, central region. (924 aa)
Fjoh_1303PFAM: RNP-1 like RNA-binding protein. (114 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (534 aa)
Fjoh_1432PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (220 aa)
Fjoh_1463Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (355 aa)
Fjoh_1475Transketolase, central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (325 aa)
Fjoh_1552TIGRFAM: pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein. (545 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (332 aa)
Fjoh_1651Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))., Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding. (763 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
Fjoh_1656Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (259 aa)
gpmIPhosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (505 aa)
lipBLipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (232 aa)
Fjoh_1951Aconitase; PFAM: aconitate hydratase domain protein; aconitate hydratase 2. (923 aa)
Fjoh_1952Aconitase; TIGRFAM: aconitate hydratase; PFAM: aconitate hydratase domain protein. (765 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (218 aa)
Fjoh_2129D-lactate dehydrogenase (cytochrome); PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; FAD linked oxidase domain protein. (968 aa)
Fjoh_2133TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein. (467 aa)
Fjoh_2160TIGRFAM: glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (484 aa)
Fjoh_2161PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase. (1519 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa)
Fjoh_2181TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate dehydrogenase NADP-dependent, monomeric type; Belongs to the monomeric-type IDH family. (740 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (311 aa)
Fjoh_2271PFAM: aminotransferase, class V; aminotransferase, class I and II. (398 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa)
Fjoh_2344Glutamate--ammonia ligase; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp. (338 aa)
Fjoh_2345PFAM: glutamine synthetase, catalytic region. (729 aa)
Fjoh_2409PFAM: ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family. (504 aa)
mqoTIGRFAM: malate--quinone oxidoreductase; PFAM: FAD dependent oxidoreductase; Malate:quinone-oxidoreductase. (497 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (360 aa)
Fjoh_2638PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein. (63 aa)
Fjoh_2806Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (861 aa)
Fjoh_2840PFAM: dehydrogenase, E1 component; Transketolase, central region; Transketolase domain protein. (658 aa)
Fjoh_2859Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (636 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
Fjoh_2967PFAM: aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (501 aa)
Fjoh_3293PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein. (352 aa)
Fjoh_3325TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein. (636 aa)
Fjoh_3326Succinate dehydrogenase/fumarate reductase iron-sulfur subunit; PFAM: ferredoxin; 4Fe-4S ferredoxin, iron-sulfur binding domain protein. (248 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (394 aa)
Fjoh_3529Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (697 aa)
Fjoh_3835PFAM: amine oxidase. (573 aa)
Fjoh_3836PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein. (586 aa)
Fjoh_4167PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein. (341 aa)
Fjoh_4210PFAM: protein of unknown function DUF162. (195 aa)
Fjoh_4211PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein. (467 aa)
Fjoh_4212PFAM: protein of unknown function DUF224, cysteine-rich region domain protein. (246 aa)
Fjoh_4244PFAM: aldehyde dehydrogenase. (452 aa)
Fjoh_4334PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (415 aa)
gcvH-2Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
gcvT-2Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (369 aa)
Fjoh_4452PFAM: glycine cleavage H-protein. (123 aa)
Fjoh_4512Transketolase domain protein; PFAM: dehydrogenase, E1 component; Transketolase, central region; Transketolase domain protein. (804 aa)
tal-2Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (218 aa)
Fjoh_4590TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (328 aa)
Fjoh_4676TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD dependent oxidoreductase. (462 aa)
Fjoh_4713PFAM: aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (442 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
Fjoh_4811D-lactate dehydrogenase (cytochrome); PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; FAD linked oxidase domain protein. (971 aa)
Fjoh_4869PFAM: aldehyde dehydrogenase. (526 aa)
Fjoh_4988PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein. (451 aa)
Your Current Organism:
Flavobacterium johnsoniae
NCBI taxonomy Id: 376686
Other names: F. johnsoniae UW101, Flavobacterium johnsoniae ATCC 17061, Flavobacterium johnsoniae DSM 2064, Flavobacterium johnsoniae IAM 14304, Flavobacterium johnsoniae IFO 14942, Flavobacterium johnsoniae MYX.1.1.1, Flavobacterium johnsoniae NBRC 14942, Flavobacterium johnsoniae NCIB 11054, Flavobacterium johnsoniae UW101, Flavobacterium johnsoniae str. UW101, Flavobacterium johnsoniae strain UW101
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