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fumC fumC Fjoh_4869 Fjoh_4869 Fjoh_2161 Fjoh_2161 Fjoh_1494 Fjoh_1494 Fjoh_1360 Fjoh_1360 Fjoh_1225 Fjoh_1225 Fjoh_1109 Fjoh_1109 Fjoh_1014 Fjoh_1014 Fjoh_0856 Fjoh_0856 Fjoh_0535 Fjoh_0535 Fjoh_0516 Fjoh_0516 Fjoh_0514 Fjoh_0514 aroA aroA kynU kynU kmo kmo Fjoh_2160 Fjoh_2160 Fjoh_0205 Fjoh_0205 lysA lysA Fjoh_1910 Fjoh_1910 hutU hutU aroQ aroQ Fjoh_1753 Fjoh_1753 Fjoh_1651 Fjoh_1651 Fjoh_0084 Fjoh_0084 aroK aroK dapF dapF Fjoh_2409 Fjoh_2409 Fjoh_2524 Fjoh_2524 Fjoh_2575 Fjoh_2575 Fjoh_2576 Fjoh_2576 Fjoh_2589 Fjoh_2589 Fjoh_2806 Fjoh_2806 Fjoh_2814 Fjoh_2814 Fjoh_2823 Fjoh_2823 Fjoh_2826 Fjoh_2826 Fjoh_2967 Fjoh_2967 Fjoh_3327 Fjoh_3327 Fjoh_3428 Fjoh_3428 dapA dapA Fjoh_3738 Fjoh_3738 nadA nadA Fjoh_4244 Fjoh_4244 hutI hutI aroC aroC Amidohydrolase Amidohydrolase Fjoh_4713 Fjoh_4713
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
Fjoh_4869PFAM: aldehyde dehydrogenase. (526 aa)
Fjoh_2161PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase. (1519 aa)
Fjoh_1494TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; homoserine dehydrogenase; homoserine dehydrogenase, NAD-binding. (804 aa)
Fjoh_1360Peptidase subfamily M20A; PFAM: peptidase M20; peptidase dimerisation domain protein. (463 aa)
Fjoh_1225PFAM: aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (517 aa)
Fjoh_1109PFAM: phenylalanine/histidine ammonia-lyase. (506 aa)
Fjoh_1014Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (119 aa)
Fjoh_0856SMART: zinc finger, CDGSH-type domain protein. (75 aa)
Fjoh_0535TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family. (419 aa)
Fjoh_0516PFAM: aminotransferase, class I and II. (381 aa)
Fjoh_0514PFAM: Chorismate mutase; DAHP synthetase I/KDSA. (360 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (409 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (425 aa)
kmoKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. (446 aa)
Fjoh_2160TIGRFAM: glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (484 aa)
Fjoh_0205PFAM: dihydrodipicolinate reductase; Belongs to the DapB family. (233 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (407 aa)
Fjoh_1910Hypothetical protein. (60 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (658 aa)
aroQ3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (137 aa)
Fjoh_1753TIGRFAM: delta-1-pyrroline-5-carboxylate dehydrogenase; PFAM: aldehyde dehydrogenase. (541 aa)
Fjoh_1651Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))., Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding. (763 aa)
Fjoh_0084Hypothetical protein. (120 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (260 aa)
Fjoh_2409PFAM: ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family. (504 aa)
Fjoh_25242,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (271 aa)
Fjoh_2575TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding. (815 aa)
Fjoh_2576TIGRFAM: histidine ammonia-lyase; PFAM: phenylalanine/histidine ammonia-lyase. (523 aa)
Fjoh_2589PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding, N-terminal domain protein. (249 aa)
Fjoh_2806Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (861 aa)
Fjoh_2814PFAM: Proline dehydrogenase. (389 aa)
Fjoh_2823PFAM: monooxygenase, FAD-binding; FAD dependent oxidoreductase. (371 aa)
Fjoh_2826PFAM: monooxygenase, FAD-binding. (387 aa)
Fjoh_2967PFAM: aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (501 aa)
Fjoh_3327PFAM: dihydrodipicolinate reductase; Belongs to the DapB family. (249 aa)
Fjoh_3428PFAM: peptidase M20; peptidase dimerisation domain protein. (356 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa)
Fjoh_3738PFAM: amidohydrolase; Amidohydrolase 3. (432 aa)
nadAQuinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (310 aa)
Fjoh_4244PFAM: aldehyde dehydrogenase. (452 aa)
hutITIGRFAM: imidazolonepropionase; PFAM: amidohydrolase; Amidohydrolase 3; Belongs to the metallo-dependent hydrolases superfamily. HutI family. (411 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (352 aa)
AmidohydrolaseTIGRFAM: amidohydrolase; PFAM: peptidase M20. (427 aa)
Fjoh_4713PFAM: aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (442 aa)
Your Current Organism:
Flavobacterium johnsoniae
NCBI taxonomy Id: 376686
Other names: F. johnsoniae UW101, Flavobacterium johnsoniae ATCC 17061, Flavobacterium johnsoniae DSM 2064, Flavobacterium johnsoniae IAM 14304, Flavobacterium johnsoniae IFO 14942, Flavobacterium johnsoniae MYX.1.1.1, Flavobacterium johnsoniae NBRC 14942, Flavobacterium johnsoniae NCIB 11054, Flavobacterium johnsoniae UW101, Flavobacterium johnsoniae str. UW101, Flavobacterium johnsoniae strain UW101
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