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adk adk pssA pssA psd psd pyrG pyrG plsX plsX engC engC rfaG rfaG pfkA pfkA fba fba csdB csdB eda eda cmk cmk miaA miaA pgsA pgsA tdk tdk glyA glyA lpd lpd aceF aceF acoB acoB acoA acoA ATP_00163 ATP_00163 tpiA tpiA plsY plsY spoT spoT qns qns nrdF nrdF nrdA nrdA glnS glnS lplA lplA dut dut pyrH pyrH cdsA cdsA tilS tilS metK metK ackA ackA thyA thyA folA folA plsC plsC gltX gltX tmk tmk metG metG pgi pgi tmk-2 tmk-2 pepA pepA acpP acpP gmk gmk
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (224 aa)
pssACDP-diacylglycerol-serine O-phosphatidyltransferase. (247 aa)
psdPhosphatidylserine decarboxylase proenzyme; Belongs to the phosphatidylserine decarboxylase family. (291 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (541 aa)
plsXFatty acid/phospholipid biosynthesis enzyme; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (350 aa)
engCGTPase EngC; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (304 aa)
rfaGGlucosyltransferase involved in LPS biosynthesis. (398 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (319 aa)
fbaFructose-bisphosphate aldolase. (287 aa)
csdBNifS-like protein (selenocysteine lyase). (404 aa)
eda2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase. (221 aa)
cmkCytidylate kinase. (232 aa)
miaAtRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (299 aa)
pgsACDP-diacylglycerol-3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (218 aa)
tdkThymidine kinase. (193 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (419 aa)
lpdDihydrolipoamide dehydrogenase. (460 aa)
aceFBranched-chain alpha-keto acid dehydrogenase subunit E2 (lipoate acyltransferase). (419 aa)
acoBThiamine pyrophosphate-dependent dehydrogenase, E1 component (beta subunit, PdhB-like). (326 aa)
acoAThiamine pyrophosphate-dependent dehydrogenase, E1 component alpha subunit (pyruvate dehydrogenase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (363 aa)
ATP_00163Exopolyphosphatase-related protein. (313 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (258 aa)
plsYPhage integrase, fragment; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (211 aa)
spoTGuanosine-3'-5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (734 aa)
qnsGlutamine-dependent NAD(+) synthetase. (598 aa)
nrdFRibonucleoside-diphosphate reductase, beta chain. (348 aa)
nrdARibonucleotide reductase, alpha subunit (Coenzyme B12-dependent; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (830 aa)
glnSglutaminyl-tRNA synthetase. (540 aa)
lplALipoate-protein ligase A. (337 aa)
dutDUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (155 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa)
cdsAPhosphatidate cytidylyltransferase; Belongs to the CDS family. (297 aa)
tilStRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (415 aa)
metKS-adenosylmethionine synthetase; Belongs to the AdoMet synthase family. (377 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (391 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (288 aa)
folADihydrofolate reductase; Belongs to the dihydrofolate reductase family. (157 aa)
plsC1-acyl-sn-glycerol-3-phosphate acyltransferase. (265 aa)
gltXGlutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (444 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (208 aa)
metGMethiony-tRNA synthetase. (517 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (426 aa)
tmk-2Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (205 aa)
pepAPutative aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (498 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (84 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (210 aa)
Your Current Organism:
Phytoplasma mali
NCBI taxonomy Id: 37692
Other names: Apple proliferation mycoplasma-like organism, Apple proliferation phytoplasma, C. Phytoplasma mali, Candidatus Phytoplasma mali
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