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| | glcB | Putative malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (724 aa) |
| | ACR12489.1 | Putative isocitrate lyase; Identified by match to protein family HMM PF00463. (532 aa) |
| | gcvT | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (363 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (130 aa) |
| | ilvA | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (504 aa) |
| | rpiA | Ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (225 aa) |
| | ACR14024.1 | D-3-phosphoglycerate dehydrogenase; Identified by match to protein family HMM PF00389; match to protein family HMM PF01842; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (411 aa) |
| | fghA_1 | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (280 aa) |
| | ACR11241.1 | S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Identified by match to protein family HMM PF00107; match to protein family HMM PF08240; match to protein family HMM TIGR02818; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (368 aa) |
| | gnd | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (484 aa) |
| | ACR13338.1 | Gluconolaconase domain protein; Identified by match to protein family HMM PF08450. (298 aa) |
| | acsA | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (646 aa) |
| | ppc | Phosphoenolpyruvate carboxykinase (GTP); Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (878 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa) |
| | ACR10990.1 | Phosphoserine phosphatase; Identified by match to protein family HMM PF00702; match to protein family HMM PF01842; match to protein family HMM PF06888; match to protein family HMM PF08282; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488. (402 aa) |
| | ACR13924.1 | Serine acetyltransferase; Identified by match to protein family HMM PF06426; match to protein family HMM TIGR01172. (269 aa) |
| | gcvP | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa) |
| | ACR11308.1 | Carbohydrate kinase, thermoresistant glucokinase family; Identified by match to protein family HMM PF01202; match to protein family HMM TIGR01313. (175 aa) |
| | ACR10669.1 | Putative 2-dehydro-3-deoxygluconokinase; Identified by match to protein family HMM PF00294. (317 aa) |
| | ACR14015.1 | Identified by match to protein family HMM PF01081; match to protein family HMM TIGR01182. (209 aa) |
| | ACR13455.1 | Kinase, pfkB family; Identified by match to protein family HMM PF00294. (366 aa) |
| | pgi | Glucose-6-phosphate isomerase; Identified by match to protein family HMM PF00342; Belongs to the GPI family. (546 aa) |
| | fbaA | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (358 aa) |
| | fabV | Short-chain alcohol dehydrogenase; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (396 aa) |
| | aceE | Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (884 aa) |
| | aceF | Dihydrolipoyllysine-residue acetyltransferase E2 component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (649 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (318 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (535 aa) |
| | ACR12509.1 | NADP-dependent malic enzyme; Identified by match to protein family HMM PF00390; match to protein family HMM PF03949. (535 aa) |
| | nifP | Serine acetyltransferase NifP; Identified by match to protein family HMM PF00132; match to protein family HMM TIGR01172. (273 aa) |
| | fadB | Fatty oxidation complex, alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (720 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (327 aa) |
| | thrH | Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR02137. (205 aa) |
| | ACR12642.1 | Pyruvate kinase; Identified by match to protein family HMM PF00224; Belongs to the pyruvate kinase family. (503 aa) |
| | acnB | Aconitate hydratase 2; Identified by match to protein family HMM PF00330; match to protein family HMM PF06434; match to protein family HMM TIGR00117; Belongs to the aconitase/IPM isomerase family. (877 aa) |
| | folD | Tetrahydrofolate dehydrogenase/cyclohydrolase FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (280 aa) |
| | ACR14526.1 | Isocitrate dehydrogenase, NADP-dependent; Identified by match to protein family HMM PF03971; match to protein family HMM TIGR00178; Belongs to the monomeric-type IDH family. (742 aa) |
| | ACR12761.1 | 2-oxo acid dehydrogenases acyltransferase; Identified by match to protein family HMM PF00198. (252 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (289 aa) |
| | sucD | succinyl-CoA ligase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa) |
| | sucC | Putative succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa) |
| | lpdA | Dihydrolipoyl dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR01350. (483 aa) |
| | sucB | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoyllysine-residue succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (412 aa) |
| | sucA | Oxoglutarate dehydrogenase (succinyl-transferring), E1 component; Identified by match to protein family HMM PF00676; match to protein family HMM PF02779; match to protein family HMM TIGR00239. (945 aa) |
| | ACR13668.1 | Succinate dehydrogenase / fumarate reductase family protein, iron-sulfur subunit; Identified by similarity to SP:P07014; match to protein family HMM TIGR00384. (234 aa) |
| | sdhA | Succinate dehydrogenase, flavoprotein subunit; Identified by match to protein family HMM PF00890; match to protein family HMM PF02910; match to protein family HMM TIGR01812; match to protein family HMM TIGR01816; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (590 aa) |
| | sdhD | Succinate dehydrogenase, hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (123 aa) |
| | sdhC | Succinate dehydrogenase, cytochrome b556 subunit; Identified by match to protein family HMM PF01127; match to protein family HMM TIGR02970. (124 aa) |
| | gltA | Citrate-synthase; Identified by match to protein family HMM PF00285; match to protein family HMM TIGR01798; Belongs to the citrate synthase family. (437 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (310 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase, type I; Identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa) |
| | zwf | Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (496 aa) |
| | fbp | Fructose-1,6-bisphosphatase; Identified by match to protein family HMM PF00316. (335 aa) |
| | ACR11907.1 | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain protein; Identified by match to protein family HMM PF00389; match to protein family HMM PF01842; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (393 aa) |
| | ACR12564.1 | Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (372 aa) |
| | phbB | acetoacetyl-CoA reductase; Identified by match to protein family HMM PF00106; match to protein family HMM PF01370; match to protein family HMM PF08659; match to protein family HMM TIGR01829. (241 aa) |
| | pyk | Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. (482 aa) |
| | ACR10787.1 | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (717 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (401 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (439 aa) |
| | glk | Glucokinase; Identified by match to protein family HMM PF02685; match to protein family HMM TIGR00749; Belongs to the bacterial glucokinase family. (319 aa) |
| | ACR11599.1 | Hydro-lyase, Fe-S type, tartrate/fumarate family; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (506 aa) |
| | accB | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (154 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa) |
| | acnA | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (926 aa) |
| | fumC | Putative fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (452 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Identified by similarity to SP:P44756; match to protein family HMM PF00834; match to protein family HMM TIGR01163; Belongs to the ribulose-phosphate 3-epimerase family. (234 aa) |
| | ACR14724.1 | phosphoribulokinase/Uridine kinase Family Protein. (313 aa) |
| | tpiA | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (246 aa) |
| | nifJ | Pyruvate:ferredoxin (flavodoxin) oxidoreductase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR02176. (1195 aa) |
| | ACR14474.1 | acetyl-CoA acetyltransferase; Identified by similarity to SP:P76461; match to protein family HMM PF00108; match to protein family HMM PF02803; match to protein family HMM TIGR01930; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa) |
| | ACR11710.1 | Fumarate reductase / succinate dehydrogenase family protein, iron-sulfur subunit; Identified by similarity to SP:P17596; match to protein family HMM PF00111; match to protein family HMM TIGR00384; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (254 aa) |
| | ACR14577.1 | Succinate dehydrogenase / fumarate reductase family protein, flavoprotein subunit; Identified by similarity to SP:P0AC41; match to protein family HMM PF00890; match to protein family HMM PF01266; match to protein family HMM PF02910; match to protein family HMM PF07992; match to protein family HMM TIGR01812. (668 aa) |
| | ACR11129.1 | Fumarate reductase respiratory complex, transmembrane subunit; Identified by match to protein family HMM PF02967. (251 aa) |
| | glyA | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (422 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | ACR13547.1 | Cysteine synthase; Identified by match to protein family HMM PF00291. (306 aa) |
| | ACR12654.1 | Putative serine O-acetyltransferase; Identified by match to protein family HMM PF00132. (338 aa) |
| | pgk | Phosphoglycerate kinase; Identified by match to protein family HMM PF00162; Belongs to the phosphoglycerate kinase family. (391 aa) |
| | tkt | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (667 aa) |
| | metF | Methylenetetrahydrofolate reductase; Identified by similarity to SP:O67422; match to protein family HMM PF02219; match to protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. (282 aa) |
| | cysK | Cysteine synthase A; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139. (348 aa) |
| | ACR13670.1 | Formamidase; Identified by match to protein family HMM PF03069. (410 aa) |
| | fghA_2 | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (277 aa) |
| | ACR14448.1 | Catalase; Has an organic peroxide-dependent peroxidase activity. Belongs to the catalase family. (389 aa) |
| | gpmA | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (248 aa) |
