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GAU_1909 GAU_1909 GAU_0160 GAU_0160 GAU_0177 GAU_0177 GAU_0185 GAU_0185 GAU_0189 GAU_0189 GAU_0192 GAU_0192 thyX thyX gyrA gyrA GAU_0560 GAU_0560 GAU_0561 GAU_0561 GAU_0636 GAU_0636 mgh mgh polB polB pdhA pdhA GAU_0779 GAU_0779 gyrB gyrB rpmG rpmG rplK rplK rplA rplA rplJ rplJ rplL rplL rpsL rpsL rpsG rpsG rpsJ rpsJ rplC rplC rplD rplD rplW rplW rplB rplB rpsS rpsS rplV rplV rpsC rpsC rplP rplP rpmC rpmC rpsQ rpsQ rplN rplN rplX rplX rplE rplE rpsN rpsN rpsH rpsH rplF rplF rplR rplR rpsE rpsE rpmD rpmD rplO rplO priA priA murQ murQ recQ recQ GAU_0976 GAU_0976 GAU_1113 GAU_1113 recR recR rplI rplI rpsR rpsR rpsF rpsF rplY rplY GAU_1231 GAU_1231 ispE ispE recO recO GAU_1518 GAU_1518 rpsT rpsT miaA miaA GAU_1555 GAU_1555 ribF ribF lpxD lpxD rpmF rpmF GAU_1674 GAU_1674 dnaB dnaB rpmA rpmA rplU rplU recQ-2 recQ-2 GAU_1706 GAU_1706 rpsO rpsO rpsB rpsB rpsI rpsI rplM rplM rpsA rpsA GAU_1812 GAU_1812 rplT rplT rpmI rpmI dnaG dnaG mutS2 mutS2 rpsU rpsU nadD nadD rpmB rpmB rplQ rplQ rpsD rpsD rpsK rpsK rpsM rpsM rpmJ rpmJ nfo nfo GAU_2170 GAU_2170 GAU_2214 GAU_2214 GAU_2240 GAU_2240 GAU_2276 GAU_2276 rplS rplS rimM rimM rpsP rpsP ubiX ubiX GAU_2460 GAU_2460 GAU_2590 GAU_2590 phr phr GAU_2729 GAU_2729 GAU_2764 GAU_2764 hemA hemA rpsD-2 rpsD-2 rpmE rpmE rpmG-2 rpmG-2 GAU_2855 GAU_2855 GAU_3070 GAU_3070 GAU_3071 GAU_3071 GAU_3184 GAU_3184 glgC glgC GAU_3384 GAU_3384 GAU_3404 GAU_3404 GAU_3420 GAU_3420 GAU_3509 GAU_3509 GAU_3569 GAU_3569 GAU_3721 GAU_3721 GAU_3730 GAU_3730 sgaA sgaA hrpB hrpB selO selO GAU_3882 GAU_3882 GAU_3909 GAU_3909 GAU_3917 GAU_3917 GAU_3922 GAU_3922 rpmH rpmH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAU_1909ATPase. (459 aa)
GAU_0160Hypothetical protein. (214 aa)
GAU_0177Putative restriction endonuclease. (326 aa)
GAU_0185Hypothetical membrane protein. (669 aa)
GAU_0189Putative hydrolase. (359 aa)
GAU_0192Transaminase. (367 aa)
thyXThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (255 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (837 aa)
GAU_0560Hypothetical membrane protein. (289 aa)
GAU_0561Hypothetical protein. (220 aa)
GAU_0636Hypothetical protein. (291 aa)
mgh3-methyladenine DNA glycosylase; Belongs to the DNA glycosylase MPG family. (194 aa)
polBDNA polymerase II. (825 aa)
pdhAPyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (347 aa)
GAU_07796-pyruvoyl tetrahydropterin synthase family protein. (137 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (658 aa)
rpmG50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (50 aa)
rplK50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (140 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (229 aa)
rplJ50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (167 aa)
rplL50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (127 aa)
rpsL30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (134 aa)
rpsG30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (227 aa)
rplD50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (213 aa)
rplW50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (95 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (276 aa)
rpsS30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (96 aa)
rplV50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (125 aa)
rpsC30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (219 aa)
rplP50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (142 aa)
rpmC50S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (67 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (98 aa)
rplN50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplX50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (107 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (198 aa)
rpsN30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
rpsH30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (133 aa)
rplF50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (179 aa)
rplR50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (118 aa)
rpsE30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (272 aa)
rpmD50S ribosomal protein L30. (58 aa)
rplO50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (160 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (767 aa)
murQHypothetical protein; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (328 aa)
recQATP-dependent DNA helicase RecQ. (524 aa)
GAU_0976Hypothetical protein. (371 aa)
GAU_1113Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (104 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (199 aa)
rplI50S ribosomal protein L9; Binds to the 23S rRNA. (147 aa)
rpsR30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (73 aa)
rpsF30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (130 aa)
rplY50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (208 aa)
GAU_1231Hypothetical protein. (169 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (295 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (249 aa)
GAU_1518Hypothetical protein. (458 aa)
rpsT30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (82 aa)
miaAtRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (346 aa)
GAU_1555Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein. (116 aa)
ribFRiboflavin kinase/FMN adenylyltransferase; Bifunctional protein; protein synonym: FAD pyrophosphorylase; protein synonym: FAD synthetase; protein synonym: flavokinase; protein synonym: riboflavin biosynthesis protein RibF; Belongs to the ribF family. (326 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (360 aa)
rpmF50S ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (60 aa)
GAU_1674DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (110 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (488 aa)
rpmA50S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (97 aa)
rplU50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (105 aa)
recQ-2ATP-dependent DNA helicase RecQ. (598 aa)
GAU_1706Hypothetical protein. (458 aa)
rpsO30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (86 aa)
rpsB30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (320 aa)
rpsI30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (129 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (149 aa)
rpsA30S ribosomal protein S1. (585 aa)
GAU_1812DNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (447 aa)
rplT50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (124 aa)
rpmI50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (65 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (657 aa)
mutS2DNA mismatch repair protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (819 aa)
rpsU30S ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (62 aa)
nadDPutative nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (211 aa)
rpmB50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (73 aa)
rplQ50S ribosomal protein L17. (118 aa)
rpsD30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (211 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (125 aa)
rpsM30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (125 aa)
rpmJ50S ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (38 aa)
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (293 aa)
GAU_2170Hypothetical protein. (421 aa)
GAU_2214Hypothetical protein. (292 aa)
GAU_2240Hypothetical protein. (311 aa)
GAU_2276Hypothetical protein; Belongs to the SOS response-associated peptidase family. (234 aa)
rplS50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (118 aa)
rimMPutative 16S rRNA processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (169 aa)
rpsP30S ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (104 aa)
ubiXAromatic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (212 aa)
GAU_24606-pyruvoyl tetrahydropterin synthase family protein. (151 aa)
GAU_2590Hypothetical protein. (184 aa)
phrProtein synonym: DNA photolyase; protein synonym: photoreactivating enzyme. (495 aa)
GAU_2729Putative pterin-4-alpha-carbinolamine dehydratase; Protein synonym: 4-alpha-hydroxy-tetrahydropterin dehydratase; protein synonym: PCD; protein synonym: PHS; protein synonym: pterin carbinolamine dehydratase. (99 aa)
GAU_2764Hypothetical protein. (898 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (395 aa)
rpsD-230S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (205 aa)
rpmE50S ribosomal protein L31; Belongs to the bacterial ribosomal protein bL31 family. (82 aa)
rpmG-250S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (51 aa)
GAU_2855Hypothetical protein. (191 aa)
GAU_3070Hypothetical protein. (140 aa)
GAU_3071Putative endonuclease IV; Protein synonym: endodeoxyribonuclease IV. (299 aa)
GAU_3184Hypothetical protein. (164 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (418 aa)
GAU_3384AraC family transcriptional regulator. (298 aa)
GAU_3404Hypothetical protein. (358 aa)
GAU_3420Hypothetical protein; Belongs to the UPF0145 family. (108 aa)
GAU_3509Putative transposase orfB for insertion sequence element. (254 aa)
GAU_3569Putative DNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (407 aa)
GAU_3721Hypothetical protein. (664 aa)
GAU_3730Hypothetical protein. (142 aa)
sgaASerine--glyoxylate aminotransferase; Protein synonym: SGAT. (390 aa)
hrpBATP-dependent helicase. (849 aa)
selOHypothetical protein; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). (522 aa)
GAU_38826-pyruvoyl tetrahydropterin synthase family protein. (127 aa)
GAU_3909Putative glutamine cyclotransferase. (283 aa)
GAU_3917Hypothetical protein. (236 aa)
GAU_3922Hypothetical protein. (465 aa)
rpmH50S ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (54 aa)
Your Current Organism:
Gemmatimonas aurantiaca
NCBI taxonomy Id: 379066
Other names: G. aurantiaca T-27, Gemmatimonas aurantiaca DSM 14586, Gemmatimonas aurantiaca JCM 11422, Gemmatimonas aurantiaca NBRC 100505, Gemmatimonas aurantiaca T-27, Gemmatimonas aurantiaca str. T-27, Gemmatimonas aurantiaca strain T-27
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