STRINGSTRING
KZO57584.1 KZO57584.1 KZO57588.1 KZO57588.1 mfd mfd KZO60526.1 KZO60526.1 KZO60502.1 KZO60502.1 lexA lexA recA recA KZO60275.1 KZO60275.1 ruvC ruvC ruvA ruvA ruvB ruvB uvrC uvrC KZO60072.1 KZO60072.1 uvrA uvrA uvrB uvrB polA polA KZO59888.1 KZO59888.1 KZO59898.1 KZO59898.1 KZO59636.1 KZO59636.1 KZO59637.1 KZO59637.1 KZO59656.1 KZO59656.1 KZO59498.1 KZO59498.1 KZO58902.1 KZO58902.1 topA topA KZO58995.1 KZO58995.1 recR recR KZO59001.1 KZO59001.1 gyrA gyrA gyrB gyrB recF recF KZO58627.1 KZO58627.1 dnaA dnaA KZO58731.1 KZO58731.1 KZO58096.1 KZO58096.1 KZO57898.1 KZO57898.1 KZO57908.1 KZO57908.1 KZO57914.1 KZO57914.1 recO recO dnaG dnaG KZO57989.1 KZO57989.1 dinB dinB KZO58026.1 KZO58026.1 KZO57806.1 KZO57806.1 KZO57668.1 KZO57668.1 KZO57669.1 KZO57669.1 dnaE2 dnaE2 KZO57830.1 KZO57830.1 KZO57831.1 KZO57831.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KZO57584.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (323 aa)
KZO57588.1TraA protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1174 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1220 aa)
KZO60526.1DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (595 aa)
KZO60502.1TraA protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1109 aa)
lexARepressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (222 aa)
recADNA recombination/repair protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (367 aa)
KZO60275.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (219 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (199 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (368 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (695 aa)
KZO60072.1ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology. (823 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (1022 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (709 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (900 aa)
KZO59888.15'-3' exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
KZO59898.1Daunorubicin resistance protein DrrC; Derived by automated computational analysis using gene prediction method: Protein Homology. (782 aa)
KZO59636.12-hydroxyhepta-2,4-diene-1,7-dioate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
KZO59637.1DNA polymerase III subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology. (240 aa)
KZO59656.1DNA polymerase III subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
KZO59498.1Helicase SNF2; Derived by automated computational analysis using gene prediction method: Protein Homology. (1126 aa)
KZO58902.1DNA polymerase III subunit delta; Catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (999 aa)
KZO58995.1DNA polymerase III subunit epsilon; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (268 aa)
KZO59001.1DNA polymerase III subunit gamma/tau; Derived by automated computational analysis using gene prediction method: Protein Homology. (892 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (842 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (705 aa)
recFDNA replication/repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (410 aa)
KZO58627.1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (391 aa)
dnaAChromosomal replication initiation protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (501 aa)
KZO58731.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (607 aa)
KZO58096.1ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (889 aa)
KZO57898.1Recombinase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (725 aa)
KZO57908.1Recombinase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (551 aa)
KZO57914.1DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (317 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (675 aa)
KZO57989.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (547 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (486 aa)
KZO58026.1DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1181 aa)
KZO57806.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (695 aa)
KZO57668.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily. (1108 aa)
KZO57669.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily. (1093 aa)
dnaE2Error-prone DNA polymerase; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1049 aa)
KZO57830.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (550 aa)
KZO57831.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
Your Current Organism:
Dietzia maris
NCBI taxonomy Id: 37915
Other names: ATCC 35013, AUCNM A-593, AUCNM:A:593, Brevibacterium maris, CCUG 44488, CIP 104188, D. maris, DSM 43672, IEGM 55, IFO 15801, IMV 195, JCM 6166, LMG 5361, LMG:5361, NBRC 15801, NRRL B-16941, NRRL:B:16941, Rhodococcus maris, VKM Ac-593, VKM:Ac:593
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