STRINGSTRING
KZO60221.1 KZO60221.1 KZO60556.1 KZO60556.1 mfd mfd lexA lexA recA recA ruvC ruvC ruvA ruvA ruvB ruvB uvrC uvrC KZO60222.1 KZO60222.1 KZO60235.1 KZO60235.1 KZO60132.1 KZO60132.1 KZO60175.1 KZO60175.1 KZO60178.1 KZO60178.1 KZO59995.1 KZO59995.1 uvrA uvrA uvrB uvrB polA polA KZO59875.1 KZO59875.1 KZO59898.1 KZO59898.1 KZO59817.1 KZO59817.1 mutM mutM KZO59618.1 KZO59618.1 ung ung KZO59627.1 KZO59627.1 ligA ligA KZO59533.1 KZO59533.1 KZO59539.1 KZO59539.1 KZO59360.1 KZO59360.1 KZO59378.1 KZO59378.1 A2U19_07815 A2U19_07815 KZO59314.1 KZO59314.1 KZO59098.1 KZO59098.1 KZO59101.1 KZO59101.1 KZO58910.1 KZO58910.1 nth nth recR recR recF recF KZO58565.1 KZO58565.1 A2U19_12460 A2U19_12460 KZO58096.1 KZO58096.1 KZO57868.1 KZO57868.1 KZO57906.1 KZO57906.1 recO recO KZO58074.1 KZO58074.1 dinB dinB ku ku KZO57668.1 KZO57668.1 KZO57669.1 KZO57669.1 KZO57823.1 KZO57823.1 dnaE2 dnaE2 KZO57830.1 KZO57830.1 KZO57831.1 KZO57831.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KZO60221.1ATP-dependent nuclease subunit B; Derived by automated computational analysis using gene prediction method: Protein Homology. (986 aa)
KZO60556.1Fatty acid-binding protein; May play a role in the intracellular transport of hydrophobic ligands. (205 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1220 aa)
lexARepressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (222 aa)
recADNA recombination/repair protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (367 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (219 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (199 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (368 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (695 aa)
KZO60222.1DNA helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology. (1140 aa)
KZO60235.1Cysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
KZO60132.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (135 aa)
KZO60175.1ADP-ribose pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)
KZO60178.1DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (586 aa)
KZO59995.13-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DNA glycosylase MPG family. (210 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (1022 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (709 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (900 aa)
KZO59875.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (720 aa)
KZO59898.1Daunorubicin resistance protein DrrC; Derived by automated computational analysis using gene prediction method: Protein Homology. (782 aa)
KZO59817.13-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
mutMDNA-formamidopyrimidine glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (303 aa)
KZO59618.1ATP-dependent DNA helicase RecG; Derived by automated computational analysis using gene prediction method: Protein Homology. (756 aa)
unguracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (232 aa)
KZO59627.1NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Nudix hydrolase family. (304 aa)
ligADNA ligase (NAD(+)) LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (726 aa)
KZO59533.1Cysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
KZO59539.1NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (372 aa)
KZO59360.1Fatty acid-binding-like protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
KZO59378.1Mismatch-specific DNA-glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
A2U19_07815Adenylate cyclase; Incomplete; partial in the middle of a contig; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
KZO59314.1DNA repair protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
KZO59098.1Adenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (304 aa)
KZO59101.1DNA integrity scanning protein DisA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DisA family. (352 aa)
KZO58910.1DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (777 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (263 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (268 aa)
recFDNA replication/repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (410 aa)
KZO58565.1Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
A2U19_12460Transposase; Incomplete; too short partial abutting assembly gap; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
KZO58096.1ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (889 aa)
KZO57868.1DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (278 aa)
KZO57906.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (317 aa)
KZO58074.1AAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (821 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (486 aa)
kuKu protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (365 aa)
KZO57668.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily. (1108 aa)
KZO57669.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily. (1093 aa)
KZO57823.1Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
dnaE2Error-prone DNA polymerase; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1049 aa)
KZO57830.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (550 aa)
KZO57831.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
Your Current Organism:
Dietzia maris
NCBI taxonomy Id: 37915
Other names: ATCC 35013, AUCNM A-593, AUCNM:A:593, Brevibacterium maris, CCUG 44488, CIP 104188, D. maris, DSM 43672, IEGM 55, IFO 15801, IMV 195, JCM 6166, LMG 5361, LMG:5361, NBRC 15801, NRRL B-16941, NRRL:B:16941, Rhodococcus maris, VKM Ac-593, VKM:Ac:593
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