STRINGSTRING
xseB xseB xseA xseA KZO59378.1 KZO59378.1 KZO59498.1 KZO59498.1 ligA ligA ung ung KZO59618.1 KZO59618.1 mutM mutM xerC-2 xerC-2 KZO59817.1 KZO59817.1 KZO59898.1 KZO59898.1 KZO59888.1 KZO59888.1 KZO59975.1 KZO59975.1 polA polA uvrB uvrB KZO59940.1 KZO59940.1 uvrA uvrA KZO59995.1 KZO59995.1 KZO60072.1 KZO60072.1 KZO60026.1 KZO60026.1 KZO60100.1 KZO60100.1 KZO60102.1 KZO60102.1 xerC xerC KZO60132.1 KZO60132.1 KZO60261.1 KZO60261.1 KZO60245.1 KZO60245.1 KZO60259.1 KZO60259.1 KZO60223.1 KZO60223.1 KZO60222.1 KZO60222.1 KZO60221.1 KZO60221.1 uvrC uvrC priA priA ruvB ruvB ruvA ruvA ruvC ruvC recA recA KZO60502.1 KZO60502.1 KZO60462.1 KZO60462.1 KZO60457.1 KZO60457.1 KZO60454.1 KZO60454.1 KZO60451.1 KZO60451.1 KZO60526.1 KZO60526.1 KZO60583.1 KZO60583.1 KZO60595.1 KZO60595.1 KZO57588.1 KZO57588.1 KZO57633.1 KZO57633.1 KZO57637.1 KZO57637.1 KZO57638.1 KZO57638.1 KZO58387.1 KZO58387.1 A2U19_00060 A2U19_00060 KZO58902.1 KZO58902.1 topA topA nth nth KZO59001.1 KZO59001.1 KZO59044.1 KZO59044.1 KZO58886.1 KZO58886.1 KZO58871.1 KZO58871.1 KZO58813.1 KZO58813.1 nucS nucS gyrA gyrA gyrB gyrB KZO58627.1 KZO58627.1 KZO58731.1 KZO58731.1 KZO59417.1 KZO59417.1 KZO58565.1 KZO58565.1 KZO58405.1 KZO58405.1 KZO58406.1 KZO58406.1 KZO58408.1 KZO58408.1 KZO58472.1 KZO58472.1 A2U19_12460 A2U19_12460 KZO58091.1 KZO58091.1 KZO58096.1 KZO58096.1 KZO58141.1 KZO58141.1 A2U19_14000 A2U19_14000 KZO57868.1 KZO57868.1 KZO58057.1 KZO58057.1 KZO57914.1 KZO57914.1 KZO58074.1 KZO58074.1 KZO57989.1 KZO57989.1 dinB dinB KZO58026.1 KZO58026.1 KZO57806.1 KZO57806.1 KZO57668.1 KZO57668.1 KZO57669.1 KZO57669.1 KZO57823.1 KZO57823.1 dnaE2 dnaE2 KZO57830.1 KZO57830.1 KZO57795.1 KZO57795.1 KZO59428.1 KZO59428.1 A2U19_07815 A2U19_07815 KZO59077.1 KZO59077.1 KZO59098.1 KZO59098.1 KZO59165.1 KZO59165.1 A2U19_08805 A2U19_08805 KZO59460.1 KZO59460.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
xseBExodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (77 aa)
xseAExodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (447 aa)
KZO59378.1Mismatch-specific DNA-glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
KZO59498.1Helicase SNF2; Derived by automated computational analysis using gene prediction method: Protein Homology. (1126 aa)
ligADNA ligase (NAD(+)) LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (726 aa)
unguracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (232 aa)
KZO59618.1ATP-dependent DNA helicase RecG; Derived by automated computational analysis using gene prediction method: Protein Homology. (756 aa)
mutMDNA-formamidopyrimidine glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (303 aa)
xerC-2Recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (319 aa)
KZO59817.13-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
KZO59898.1Daunorubicin resistance protein DrrC; Derived by automated computational analysis using gene prediction method: Protein Homology. (782 aa)
KZO59888.15'-3' exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
KZO59975.1Nuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (536 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (900 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (709 aa)
KZO59940.1Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (810 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (1022 aa)
KZO59995.13-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DNA glycosylase MPG family. (210 aa)
KZO60072.1ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology. (823 aa)
KZO60026.1DNAase; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
KZO60100.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (97 aa)
KZO60102.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
xerCSite-specific tyrosine recombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (316 aa)
KZO60132.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (135 aa)
KZO60261.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)
KZO60245.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (277 aa)
KZO60259.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
KZO60223.1DNA gyrase subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa)
KZO60222.1DNA helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology. (1140 aa)
KZO60221.1ATP-dependent nuclease subunit B; Derived by automated computational analysis using gene prediction method: Protein Homology. (986 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (695 aa)
priAPrimosome assembly protein PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (681 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (368 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (199 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (219 aa)
recADNA recombination/repair protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (367 aa)
KZO60502.1TraA protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1109 aa)
KZO60462.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (1970 aa)
KZO60457.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (193 aa)
KZO60454.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (846 aa)
KZO60451.1DNA resolvase; Derived by automated computational analysis using gene prediction method: Protein Homology. (186 aa)
KZO60526.1DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (595 aa)
KZO60583.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (539 aa)
KZO60595.1ATP-dependent helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (702 aa)
KZO57588.1TraA protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1174 aa)
KZO57633.1Invertase; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
KZO57637.1Recombinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (125 aa)
KZO57638.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
KZO58387.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
A2U19_00060Transposase; Incomplete; too short partial abutting assembly gap; missing start; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (128 aa)
KZO58902.1DNA polymerase III subunit delta; Catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (999 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (263 aa)
KZO59001.1DNA polymerase III subunit gamma/tau; Derived by automated computational analysis using gene prediction method: Protein Homology. (892 aa)
KZO59044.1Recombinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)
KZO58886.1Invertase; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
KZO58871.1Recombinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (126 aa)
KZO58813.1Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (985 aa)
nucSEndonuclease; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (226 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (842 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (705 aa)
KZO58627.1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (391 aa)
KZO58731.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (607 aa)
KZO59417.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
KZO58565.1Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
KZO58405.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (154 aa)
KZO58406.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
KZO58408.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
KZO58472.1DNA lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
A2U19_12460Transposase; Incomplete; too short partial abutting assembly gap; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
KZO58091.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
KZO58096.1ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (889 aa)
KZO58141.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
A2U19_14000Transposase; Incomplete; too short partial abutting assembly gap; missing start; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (443 aa)
KZO57868.1DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (278 aa)
KZO58057.1AAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
KZO57914.1DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
KZO58074.1AAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (821 aa)
KZO57989.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (547 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (486 aa)
KZO58026.1DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1181 aa)
KZO57806.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (695 aa)
KZO57668.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily. (1108 aa)
KZO57669.1ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily. (1093 aa)
KZO57823.1Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
dnaE2Error-prone DNA polymerase; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1049 aa)
KZO57830.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (550 aa)
KZO57795.1Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (555 aa)
KZO59428.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (77 aa)
A2U19_07815Adenylate cyclase; Incomplete; partial in the middle of a contig; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
KZO59077.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (394 aa)
KZO59098.1Adenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (304 aa)
KZO59165.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
A2U19_08805Hypothetical protein; Incomplete; too short partial abutting assembly gap; missing stop; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (491 aa)
KZO59460.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (190 aa)
Your Current Organism:
Dietzia maris
NCBI taxonomy Id: 37915
Other names: ATCC 35013, AUCNM A-593, AUCNM:A:593, Brevibacterium maris, CCUG 44488, CIP 104188, D. maris, DSM 43672, IEGM 55, IFO 15801, IMV 195, JCM 6166, LMG 5361, LMG:5361, NBRC 15801, NRRL B-16941, NRRL:B:16941, Rhodococcus maris, VKM Ac-593, VKM:Ac:593
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