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trpF trpF AMM30901.1 AMM30901.1 pheA pheA AMM30990.1 AMM30990.1 hisC hisC hisB hisB hisH hisH hisA hisA AMM32397.1 AMM32397.1 argC argC argJ argJ argB argB argD argD AMM32402.1 AMM32402.1 argR argR AMM32404.1 AMM32404.1 argG argG argH argH AMM32449.1 AMM32449.1 hisD hisD hisE hisE hisG hisG hisF hisF hisI hisI trpE trpE trpC trpC trpB trpB trpA trpA trpD trpD AMM32778.1 AMM32778.1 AMM33369.1 AMM33369.1 AMM33713.1 AMM33713.1 ldh ldh AMM34041.1 AMM34041.1 pat pat AMM34391.1 AMM34391.1 AMM34393.1 AMM34393.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
trpFPfam:pfam00697 N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (209 aa)
AMM30901.1Anthranilate synthase; Pfam:pfam00117 Glutamine amidotransferase class-I. (213 aa)
pheAPfam:pfam00800 Prephenate dehydratase. (310 aa)
AMM30990.1Pfam:pfam00583 Acetyltransferase (GNAT) family; Belongs to the acetyltransferase family. (182 aa)
hisCPfam:pfam00155 Aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (373 aa)
hisBPfam:pfam00475 Imidazoleglycerol-phosphate dehydratase. (210 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (252 aa)
hisAPhosphoribosyl isomerase; Pfam:pfam00977 Histidine biosynthesis protein. (246 aa)
AMM32397.1NADPH--quinone reductase; Pfam:pfam00107 Zinc-binding dehydrogenase. (289 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (354 aa)
argJN-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (388 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (321 aa)
argDPfam:pfam00202 Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (439 aa)
AMM32402.1Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (323 aa)
argRArginine repressor; Regulates arginine biosynthesis genes. (174 aa)
AMM32404.1Glyoxalase; Pfam:pfam13669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily. (146 aa)
argGPfam:pfam00764 Arginosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (401 aa)
argHPfam:pfam00206 Lyase. (478 aa)
AMM32449.1Pfam:pfam02153 Prephenate dehydrogenase. (366 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (460 aa)
hisEPfam:pfam01503 Phosphoribosyl-ATP pyrophosphohydrolase. (87 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (281 aa)
hisFImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (131 aa)
trpEAnthranilate synthase subunit I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrat [...] (532 aa)
trpCPfam:pfam00218 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (280 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (471 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (344 aa)
AMM32778.1Pfam:pfam00155 Aminotransferase class I and II. (402 aa)
AMM33369.1Pfam:pfam00800 Prephenate dehydratase. (284 aa)
AMM33713.1Pfam:pfam00155 Aminotransferase class I and II. (401 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (317 aa)
AMM34041.1Anthranilate synthase; Pfam:pfam00425 chorismate binding enzyme. (390 aa)
patAminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (384 aa)
AMM34391.1GCN5-related N-acetyltransferase; Pfam:pfam00583 Acetyltransferase (GNAT) family. (169 aa)
AMM34393.1GCN5-related N-acetyltransferase; Pfam:pfam00583 Acetyltransferase (GNAT) family. (167 aa)
Your Current Organism:
Sinomonas atrocyanea
NCBI taxonomy Id: 37927
Other names: ATCC 13752, Arthrobacter atricyaneus, Arthrobacter atrocyaneus, CIP 102365, DSM 20127, KCTC 3377, LMG 3814, LMG:3814, NBRC 12956, S. atrocyanea
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