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AMM30790.1 AMM30790.1 AMM30890.1 AMM30890.1 gcvP gcvP gcvT gcvT gcvH gcvH glyA glyA glyA-2 glyA-2 AMM31813.1 AMM31813.1 AMM31814.1 AMM31814.1 AMM31815.1 AMM31815.1 AMM31816.1 AMM31816.1 purU-2 purU-2 glyA-3 glyA-3 folD folD gcvH-2 gcvH-2 fhs fhs AMM34106.1 AMM34106.1 AMM34360.1 AMM34360.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AMM30790.1N-methyltryptophan oxidase; Pfam:pfam01266 FAD dependent oxidoreductase. (375 aa)
AMM30890.1Sarcosine dehydrogenase; Pfam:pfam01571 Aminomethyltransferase folate-binding domain; Belongs to the GcvT family. (830 aa)
gcvPGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (959 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (388 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (439 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (438 aa)
AMM31813.1Sarcosine oxidase subunit beta; Pfam:pfam01266 FAD dependent oxidoreductase. (405 aa)
AMM31814.1Pfam:pfam04267 Sarcosine oxidase, delta subunit family. (102 aa)
AMM31815.1Ferredoxin; Pfam:pfam01571 Aminomethyltransferase folate-binding domain. (989 aa)
AMM31816.1Pfam:pfam04268 Sarcosine oxidase, gamma subunit family. (224 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (298 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (430 aa)
folDBifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (301 aa)
gcvH-2Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa)
fhsPfam:pfam01268 Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (575 aa)
AMM34106.1FAD dependent oxidoreductase-aminomethyl transferase; Pfam:pfam01571 Aminomethyltransferase folate-binding domain; Belongs to the GcvT family. (839 aa)
AMM34360.1Sarcosine oxidase; Pfam:pfam01266 FAD dependent oxidoreductase. (376 aa)
Your Current Organism:
Sinomonas atrocyanea
NCBI taxonomy Id: 37927
Other names: ATCC 13752, Arthrobacter atricyaneus, Arthrobacter atrocyaneus, CIP 102365, DSM 20127, KCTC 3377, LMG 3814, LMG:3814, NBRC 12956, S. atrocyanea
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