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trpF trpF pheA pheA hisC hisC hisA hisA AMM32449.1 AMM32449.1 AMM32469.1 AMM32469.1 trpE trpE trpC trpC trpB trpB trpA trpA trpD trpD AMM32778.1 AMM32778.1 aroB aroB aroC aroC AMM32824.1 AMM32824.1 aroA aroA AMM33311.1 AMM33311.1 AMM33369.1 AMM33369.1 AMM33467.1 AMM33467.1 AMM33713.1 AMM33713.1 AMM33922.1 AMM33922.1 aroQ aroQ pat pat aroE aroE aroE-2 aroE-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
trpFPfam:pfam00697 N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (209 aa)
pheAPfam:pfam00800 Prephenate dehydratase. (310 aa)
hisCPfam:pfam00155 Aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (373 aa)
hisAPhosphoribosyl isomerase; Pfam:pfam00977 Histidine biosynthesis protein. (246 aa)
AMM32449.1Pfam:pfam02153 Prephenate dehydrogenase. (366 aa)
AMM32469.13-deoxy-D-arabino-heptulosonate 7-phosphate synthase; Pfam:pfam01474 Class-II DAHP synthetase family; Belongs to the class-II DAHP synthase family. (464 aa)
trpEAnthranilate synthase subunit I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrat [...] (532 aa)
trpCPfam:pfam00218 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (280 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (471 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (344 aa)
AMM32778.1Pfam:pfam00155 Aminotransferase class I and II. (402 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (367 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (399 aa)
AMM32824.1Pfam:pfam08501 Shikimate dehydrogenase substrate binding domain; Belongs to the shikimate dehydrogenase family. (289 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (442 aa)
AMM33311.1Pfam:pfam01817 Chorismate mutase type II. (138 aa)
AMM33369.1Pfam:pfam00800 Prephenate dehydratase. (284 aa)
AMM33467.1Pfam:pfam08501 Shikimate dehydrogenase substrate binding domain. (272 aa)
AMM33713.1Pfam:pfam00155 Aminotransferase class I and II. (401 aa)
AMM33922.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (381 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (155 aa)
patAminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (384 aa)
aroEQuinate/shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (317 aa)
aroE-2Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (301 aa)
Your Current Organism:
Sinomonas atrocyanea
NCBI taxonomy Id: 37927
Other names: ATCC 13752, Arthrobacter atricyaneus, Arthrobacter atrocyaneus, CIP 102365, DSM 20127, KCTC 3377, LMG 3814, LMG:3814, NBRC 12956, S. atrocyanea
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