STRINGSTRING
ORC4 ORC4 TM4SF19 TM4SF19 MCMDC2 MCMDC2 FEN1 FEN1 REV1 REV1 ORC6 ORC6 MCM7 MCM7 MCM5 MCM5 MCM4 MCM4 MCM3 MCM3 CHTF18 CHTF18 ENSPCOP00000008190 ENSPCOP00000008190 DSCC1 DSCC1 MAD2L2 MAD2L2 PCNA PCNA GINS1 GINS1 MCM9 MCM9 POLH POLH POLE4 POLE4 ATAD5 ATAD5 MCM2 MCM2 POLA1 POLA1 STN1 STN1 DBF4 DBF4 TIMELESS TIMELESS REV3L REV3L POLE POLE POLD1 POLD1 GINS2 GINS2 CDT1 CDT1 MCM6 MCM6 POLA2 POLA2 RFC3 RFC3 RFC4 RFC4 RFC5 RFC5 MCMBP MCMBP MCM10 MCM10 LOC105824103 LOC105824103 GINS3 GINS3 ORC2 ORC2 POLI POLI CDC7 CDC7 ORC3 ORC3 POLD4 POLD4 POLD2 POLD2 CDC45 CDC45 MCM8 MCM8 ORC1 ORC1 POLD3 POLD3 ENSPCOP00000024945 ENSPCOP00000024945 TEN1 TEN1 RFC1 RFC1 GINS4 GINS4 CTC1 CTC1 RFC2 RFC2 POLE2 POLE2 POLE3 POLE3 CDC6 CDC6 POLK POLK PRIM1 PRIM1 WDHD1 WDHD1 LIG1 LIG1 PRIM2 PRIM2 ORC5 ORC5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
TM4SF19Uncharacterized protein. (209 aa)
MCMDC2Minichromosome maintenance domain containing 2. (678 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1197 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
MCM3DNA helicase; Belongs to the MCM family. (853 aa)
CHTF18Chromosome transmission fidelity factor 18. (998 aa)
ENSPCOP00000008190AAA domain-containing protein. (331 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (393 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (235 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
GINS1GINS complex subunit 1. (196 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1103 aa)
POLHDNA polymerase eta. (709 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (118 aa)
ATAD5ATPase family AAA domain containing 5. (1646 aa)
MCM2DNA helicase; Belongs to the MCM family. (738 aa)
POLA1DNA polymerase. (1442 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (369 aa)
DBF4DBF4 zinc finger. (676 aa)
TIMELESSTimeless circadian regulator. (1204 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3120 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa)
POLD1DNA polymerase. (1125 aa)
GINS2GINS complex subunit 2. (151 aa)
CDT1Chromatin licensing and DNA replication factor 1. (511 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (599 aa)
RFC3Replication factor C subunit 3. (356 aa)
RFC4Replication factor C subunit 4. (365 aa)
RFC5AAA domain-containing protein. (338 aa)
MCMBPMinichromosome maintenance complex binding protein. (600 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (828 aa)
LOC105824103Uncharacterized protein. (430 aa)
GINS3GINS complex subunit 3. (216 aa)
ORC2Origin recognition complex subunit 2. (546 aa)
POLIDNA polymerase iota. (735 aa)
CDC7Cell division cycle 7. (574 aa)
ORC3Origin recognition complex subunit 3. (712 aa)
POLD4Uncharacterized protein. (107 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
CDC45Cell division cycle 45. (591 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (822 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (867 aa)
POLD3DNA polymerase delta 3, accessory subunit. (359 aa)
ENSPCOP00000024945TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (97 aa)
TEN1Uncharacterized protein. (137 aa)
RFC1Replication factor C subunit 1. (1113 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (222 aa)
CTC1CST telomere replication complex component 1. (1221 aa)
RFC2Replication factor C subunit 2. (352 aa)
POLE2DNA polymerase epsilon 2, accessory subunit. (439 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (555 aa)
POLKDNA polymerase kappa. (832 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa)
WDHD1WD repeat and HMG-box DNA binding protein 1. (1007 aa)
LIG1DNA ligase. (916 aa)
PRIM2Uncharacterized protein. (158 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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