STRINGSTRING
WDR43 WDR43 TSR2 TSR2 NOP2 NOP2 ENSPCOP00000001176 ENSPCOP00000001176 ENSPCOP00000001194 ENSPCOP00000001194 KRI1 KRI1 NSUN6 NSUN6 LOC105816694 LOC105816694 RTCA RTCA DDX54 DDX54 ENSPCOP00000001984 ENSPCOP00000001984 RRP15 RRP15 METTL1 METTL1 PWP1 PWP1 TRMT61B TRMT61B RCL1 RCL1 NAT10 NAT10 PAK1IP1 PAK1IP1 GRWD1 GRWD1 UTP6 UTP6 DDX31 DDX31 NIP7 NIP7 DDX55 DDX55 ENSPCOP00000003875 ENSPCOP00000003875 ENSPCOP00000003934 ENSPCOP00000003934 LSG1 LSG1 IMP3 IMP3 RPF2 RPF2 UTP25 UTP25 ENSPCOP00000004501 ENSPCOP00000004501 PWP2 PWP2 KRR1 KRR1 FCF1 FCF1 NSUN2 NSUN2 AAMP AAMP GCC1 GCC1 PMEL PMEL RRP7A RRP7A RRP12 RRP12 MRTO4 MRTO4 ENSPCOP00000006309 ENSPCOP00000006309 LOC105805830 LOC105805830 NOL12 NOL12 GTPBP4 GTPBP4 EIF6 EIF6 BUD23 BUD23 UTP23 UTP23 NOM1 NOM1 MCC MCC PA2G4 PA2G4 PUS1 PUS1 GNL1 GNL1 SURF6 SURF6 FBL FBL NOP53 NOP53 KCTD19 KCTD19 RBM19 RBM19 DDX18 DDX18 PES1 PES1 MPHOSPH10 MPHOSPH10 GNL3L GNL3L WDR75 WDR75 LYAR LYAR NLE1 NLE1 NSA2 NSA2 GNL2 GNL2 ENSPCOP00000010560 ENSPCOP00000010560 RBM28 RBM28 ZNF593 ZNF593 SDAD1 SDAD1 UTP14A UTP14A RRP1 RRP1 NEXN NEXN CEBPZ CEBPZ IMP4 IMP4 RRP1B RRP1B TSR1 TSR1 DIMT1 DIMT1 NOP9 NOP9 ENSPCOP00000012921 ENSPCOP00000012921 BRIX1 BRIX1 DDX24 DDX24 RRP36 RRP36 RBM34 RBM34 TMA16 TMA16 HEATR1 HEATR1 P2RY11 P2RY11 UTP18 UTP18 FTSJ1 FTSJ1 NOC3L NOC3L WDR6 WDR6 TRMT11 TRMT11 LOC105817738 LOC105817738 NOL6 NOL6 UTP11 UTP11 ENSPCOP00000015424 ENSPCOP00000015424 NOC2L NOC2L TBL3 TBL3 FAM207A FAM207A TRMT9B TRMT9B THADA THADA ZNF622 ZNF622 DDX10 DDX10 WDR12 WDR12 WDR36 WDR36 RSL24D1 RSL24D1 NOC4L NOC4L TRMT6 TRMT6 BYSL BYSL FBLL1 FBLL1 METTL27 METTL27 ENSPCOP00000018567 ENSPCOP00000018567 WDR46 WDR46 ENSPCOP00000019774 ENSPCOP00000019774 DUS1L DUS1L ENSPCOP00000020089 ENSPCOP00000020089 AATF AATF RSL1D1 RSL1D1 RPF1 RPF1 RIOK3 RIOK3 URB1 URB1 FTSJ1-2 FTSJ1-2 EBNA1BP2 EBNA1BP2 BOP1 BOP1 ENSPCOP00000022366 ENSPCOP00000022366 TRMT2B TRMT2B PDCD11 PDCD11 DHX32 DHX32 NIFK NIFK BMS1 BMS1 FTSJ3 FTSJ3 RIOK2 RIOK2 RRP8 RRP8 NOP56 NOP56 NOL10 NOL10 WDR74 WDR74 DDX56 DDX56 UTP20 UTP20 DDX49 DDX49 PNO1 PNO1 SNU13 SNU13 WDR4 WDR4 TTBK1 TTBK1 DDX27 DDX27 NOB1 NOB1 RRP9 RRP9 DUS2 DUS2 UTP4 UTP4 DUS3L DUS3L P2RY1 P2RY1 TTBK2 TTBK2 GNL3 GNL3 GLMN GLMN DKC1 DKC1 NSUN5 NSUN5 LOC105807937 LOC105807937 PUM3 PUM3 ENSPCOP00000029319 ENSPCOP00000029319 ABT1 ABT1 DNTTIP2 DNTTIP2 DHX37 DHX37 NGDN NGDN ENSPCOP00000029834 ENSPCOP00000029834 NOP14 NOP14 LOC105812359 LOC105812359 DCAF13 DCAF13 DDX47 DDX47 TRMT61A TRMT61A EMG1 EMG1 NOLC1 NOLC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WDR43WD repeat domain 43. (681 aa)
TSR2TSR2 ribosome maturation factor. (191 aa)
NOP2NOP2 nucleolar protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (847 aa)
ENSPCOP00000001176Uncharacterized protein. (402 aa)
ENSPCOP00000001194Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (128 aa)
KRI1KRI1 homolog. (679 aa)
NSUN6NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (410 aa)
LOC105816694Uncharacterized protein. (106 aa)
RTCARNA 3'-terminal phosphate cyclase. (366 aa)
DDX54ATP-dependent RNA helicase DDX54; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (872 aa)
ENSPCOP00000001984Nop domain-containing protein. (284 aa)
RRP15Ribosomal RNA processing 15 homolog. (199 aa)
METTL1tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. (277 aa)
PWP1PWP1 homolog, endonuclein. (405 aa)
TRMT61BtRNA methyltransferase 61B. (482 aa)
RCL1RNA terminal phosphate cyclase like 1. (373 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa)
PAK1IP1WD_REPEATS_REGION domain-containing protein. (202 aa)
GRWD1Glutamate rich WD repeat containing 1. (447 aa)
UTP6UTP6 small subunit processome component. (598 aa)
DDX31RNA helicase. (824 aa)
NIP760S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (180 aa)
DDX55RNA helicase. (600 aa)
ENSPCOP00000003875Uncharacterized protein. (40 aa)
ENSPCOP00000003934U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; Belongs to the MPP10 family. (530 aa)
LSG1Large 60S subunit nuclear export GTPase 1. (653 aa)
IMP3IMP U3 small nucleolar ribonucleoprotein 3. (184 aa)
RPF2Ribosome production factor 2 homolog. (283 aa)
UTP25UTP25 small subunit processor component. (721 aa)
ENSPCOP0000000450160S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (118 aa)
PWP2Uncharacterized protein. (919 aa)
KRR1KRR1 small subunit processome component homolog. (261 aa)
FCF1FCF1 rRNA-processing protein. (198 aa)
NSUN2NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (738 aa)
AAMPAngio associated migratory cell protein. (391 aa)
GCC1GRIP and coiled-coil domain containing 1. (776 aa)
PMELPremelanosome protein. (670 aa)
RRP7ARibosomal RNA processing 7 homolog A. (280 aa)
RRP12Ribosomal RNA processing 12 homolog. (1293 aa)
MRTO4Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (239 aa)
ENSPCOP00000006309Uncharacterized protein. (104 aa)
LOC105805830Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (612 aa)
NOL12Uncharacterized protein. (211 aa)
GTPBP4Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (595 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (291 aa)
BUD23BUD23 rRNA methyltransferase and ribosome maturation factor. (298 aa)
UTP23Uncharacterized protein. (141 aa)
NOM1Nucleolar protein with MIF4G domain 1. (531 aa)
MCCMCC regulator of WNT signaling pathway. (825 aa)
PA2G4Proliferation-associated 2G4. (394 aa)
PUS1Pseudouridine synthase 1. (396 aa)
GNL1G protein nucleolar 1 (putative). (618 aa)
SURF6Surfeit 6. (355 aa)
FBLFibrillarin. (323 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (417 aa)
KCTD19Potassium channel tetramerization domain containing 19. (927 aa)
RBM19RNA binding motif protein 19. (959 aa)
DDX18RNA helicase. (671 aa)
PES1Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (588 aa)
MPHOSPH10U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; Belongs to the MPP10 family. (662 aa)
GNL3LG protein nucleolar 3 like. (582 aa)
WDR75WD repeat domain 75. (828 aa)
LYARLy1 antibody reactive. (364 aa)
NLE1Notchless homolog 1. (485 aa)
NSA2Uncharacterized protein. (260 aa)
GNL2Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (730 aa)
ENSPCOP00000010560Brix domain-containing protein. (297 aa)
RBM28RNA binding motif protein 28. (768 aa)
ZNF593Zinc finger protein 593. (134 aa)
SDAD1Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (553 aa)
UTP14AUncharacterized protein. (770 aa)
RRP1Ribosomal RNA processing 1. (449 aa)
NEXNNexilin F-actin binding protein. (675 aa)
CEBPZCCAAT enhancer binding protein zeta. (1052 aa)
IMP4IMP U3 small nucleolar ribonucleoprotein 4. (291 aa)
RRP1BRibosomal RNA processing 1B. (732 aa)
TSR1TSR1 ribosome maturation factor. (801 aa)
DIMT1rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (313 aa)
NOP9NOP9 nucleolar protein. (631 aa)
ENSPCOP00000012921Ribosomal_L28e domain-containing protein. (150 aa)
BRIX1Biogenesis of ribosomes BRX1. (353 aa)
DDX24DEAD-box helicase 24. (855 aa)
RRP36Ribosomal RNA processing 36. (250 aa)
RBM34RNA binding motif protein 34. (414 aa)
TMA16Translation machinery associated 16 homolog. (203 aa)
HEATR1HEAT repeat containing 1. (1927 aa)
P2RY11Purinergic receptor P2Y11; Belongs to the G-protein coupled receptor 1 family. (375 aa)
UTP18UTP18 small subunit processome component. (556 aa)
FTSJ1Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (327 aa)
NOC3LNucleolar complex protein 3 homolog. (715 aa)
WDR6WD repeat domain 6. (1149 aa)
TRMT11tRNA methyltransferase 11 homolog. (460 aa)
LOC105817738SRP40_C domain-containing protein. (706 aa)
NOL6Nucleolar protein 6. (1146 aa)
UTP11U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (253 aa)
ENSPCOP00000015424Uncharacterized protein. (160 aa)
NOC2LNOC2 like nucleolar associated transcriptional repressor. (744 aa)
TBL3Transducin beta like 3. (808 aa)
FAM207AFamily with sequence similarity 207 member A. (218 aa)
TRMT9BtRNA methyltransferase 9B (putative). (455 aa)
THADATHADA armadillo repeat containing. (1870 aa)
ZNF622Zinc finger protein 622. (473 aa)
DDX10DEAD-box helicase 10; Belongs to the DEAD box helicase family. (772 aa)
WDR12Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (398 aa)
WDR36WD repeat domain 36. (820 aa)
RSL24D1TRASH domain-containing protein. (163 aa)
NOC4LNucleolar complex associated 4 homolog. (516 aa)
TRMT6tRNA methyltransferase 6. (498 aa)
BYSLUncharacterized protein. (437 aa)
FBLL1Fibrillarin like 1. (303 aa)
METTL27Methyltransferase like 27. (242 aa)
ENSPCOP00000018567TRASH domain-containing protein. (165 aa)
WDR46WD repeat domain 46. (612 aa)
ENSPCOP00000019774TRASH domain-containing protein. (151 aa)
DUS1LDihydrouridine synthase 1 like. (475 aa)
ENSPCOP00000020089Uncharacterized protein. (96 aa)
AATFApoptosis antagonizing transcription factor. (567 aa)
RSL1D1Ribosomal L1 domain containing 1. (357 aa)
RPF1Ribosome production factor 1 homolog. (349 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
URB1URB1 ribosome biogenesis homolog. (2263 aa)
FTSJ1-2Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (312 aa)
EBNA1BP2EBNA1 binding protein 2. (334 aa)
BOP1Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (737 aa)
ENSPCOP00000022366DUF663 domain-containing protein. (140 aa)
TRMT2BtRNA methyltransferase 2 homolog B; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (503 aa)
PDCD11Programmed cell death 11. (1558 aa)
DHX32DEAH-box helicase 32 (putative). (745 aa)
NIFKNucleolar protein interacting with the FHA domain of MKI67. (185 aa)
BMS1Bms1-type G domain-containing protein. (1196 aa)
FTSJ3pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (838 aa)
RIOK2RIO kinase 2. (552 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (454 aa)
NOP56NOP56 ribonucleoprotein. (599 aa)
NOL10Nucleolar protein 10. (631 aa)
WDR74WD repeat domain 74. (384 aa)
DDX56DEAD-box helicase 56. (547 aa)
UTP20UTP20 small subunit processome component. (2664 aa)
DDX49DEAD-box helicase 49; Belongs to the DEAD box helicase family. (477 aa)
PNO1Partner of NOB1 homolog. (252 aa)
SNU13Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (132 aa)
WDR4tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. (412 aa)
TTBK1Protein kinase domain-containing protein. (668 aa)
DDX27DEAD-box helicase 27; Belongs to the DEAD box helicase family. (788 aa)
NOB1RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (409 aa)
RRP9Ribosomal RNA processing 9, U3 small nucleolar RNA binding protein. (476 aa)
DUS2Dihydrouridine synthase 2. (493 aa)
UTP4UTP4 small subunit processome component. (686 aa)
DUS3LtRNA-dihydrouridine(47) synthase [NAD(P)(+)]. (652 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
TTBK2Tau tubulin kinase 2. (1221 aa)
GNL3G protein nucleolar 3. (549 aa)
GLMNGlomulin, FKBP associated protein. (596 aa)
DKC1Dyskerin pseudouridine synthase 1. (514 aa)
NSUN5NOP2/Sun RNA methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (466 aa)
LOC105807937Brix domain-containing protein. (466 aa)
PUM3Pumilio RNA binding family member 3. (647 aa)
ENSPCOP00000029319Uncharacterized protein. (450 aa)
ABT1Activator of basal transcription 1. (275 aa)
DNTTIP2Deoxynucleotidyltransferase terminal interacting protein 2. (760 aa)
DHX37DEAH-box helicase 37. (1145 aa)
NGDNNeuroguidin. (316 aa)
ENSPCOP00000029834Uncharacterized protein. (75 aa)
NOP14NOP14 nucleolar protein. (853 aa)
LOC105812359WD_REPEATS_REGION domain-containing protein. (435 aa)
DCAF13Uncharacterized protein. (173 aa)
DDX47DEAD-box helicase 47; Belongs to the DEAD box helicase family. (455 aa)
TRMT61AtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (289 aa)
EMG1EMG1 N1-specific pseudouridine methyltransferase. (244 aa)
NOLC1LisH domain-containing protein. (665 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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