35 items (Propithecus coquereli) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPCOP00000000722	Protein kinase domain-containing protein. (67 aa)
	SHC4	SHC adaptor protein 4. (630 aa)
	PIK3R3	Uncharacterized protein. (454 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (435 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (882 aa)
	NTRK1	Tyrosine-protein kinase receptor. (796 aa)
	HCK	Tyrosine-protein kinase. (524 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (415 aa)
	RRAS	RAS related. (220 aa)
	PIK3CA	Phosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	EGFR	Receptor protein-tyrosine kinase. (1210 aa)
	PIK3R2	Uncharacterized protein. (726 aa)
	FGR	Tyrosine-protein kinase. (495 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	SRC	Tyrosine-protein kinase. (543 aa)
	INSRR	Tyrosine-protein kinase receptor. (1272 aa)
	SHC3	SHC adaptor protein 3. (596 aa)
	IRS2	Insulin receptor substrate 2. (1335 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1350 aa)
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (879 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1304 aa)
	INSR	Insulin receptor. (1192 aa)
	PIK3R6	Phosphoinositide-3-kinase regulatory subunit 6. (756 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1252 aa)
	ENSPCOP00000029403	Protein kinase domain-containing protein. (429 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	STAT3	Signal transducer and activator of transcription. (796 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	IGF2	Insulin like growth factor 2. (236 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
	SHC1	SHC adaptor protein 1. (582 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ENSPCOP00000000722	ENSPCOP00000018322	ENSPCOP00000000722	Receptor protein-tyrosine kinase.	Protein kinase domain-containing protein.	0.976
EGFR	ENSPCOP00000029403	ENSPCOP00000018322	ENSPCOP00000029403	Receptor protein-tyrosine kinase.	Protein kinase domain-containing protein.	0.989
EGFR	ERBB2	ENSPCOP00000018322	ENSPCOP00000028204	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.999
EGFR	FGR	ENSPCOP00000018322	ENSPCOP00000018420	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.727
EGFR	GRB2	ENSPCOP00000018322	ENSPCOP00000017791	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 2.	0.998
EGFR	HCK	ENSPCOP00000018322	ENSPCOP00000011835	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.836
EGFR	IGF1R	ENSPCOP00000018322	ENSPCOP00000021856	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.959
EGFR	IGF2	ENSPCOP00000018322	ENSPCOP00000030392	Receptor protein-tyrosine kinase.	Insulin like growth factor 2.	0.873
EGFR	INSR	ENSPCOP00000018322	ENSPCOP00000025685	Receptor protein-tyrosine kinase.	Insulin receptor.	0.900
EGFR	INSRR	ENSPCOP00000018322	ENSPCOP00000018723	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.815
EGFR	IRS2	ENSPCOP00000018322	ENSPCOP00000020106	Receptor protein-tyrosine kinase.	Insulin receptor substrate 2.	0.899
EGFR	NTRK1	ENSPCOP00000018322	ENSPCOP00000010652	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.674
EGFR	PDGFRB	ENSPCOP00000018322	ENSPCOP00000030751	Receptor protein-tyrosine kinase.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.962
EGFR	PIK3CA	ENSPCOP00000018322	ENSPCOP00000015588	Receptor protein-tyrosine kinase.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.982
EGFR	PIK3CB	ENSPCOP00000018322	ENSPCOP00000016466	Receptor protein-tyrosine kinase.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.952
EGFR	PIK3CD	ENSPCOP00000018322	ENSPCOP00000030279	Receptor protein-tyrosine kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.902
EGFR	PIK3CG	ENSPCOP00000018322	ENSPCOP00000015902	Receptor protein-tyrosine kinase.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.752
EGFR	PIK3R1	ENSPCOP00000018322	ENSPCOP00000018534	Receptor protein-tyrosine kinase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.993
EGFR	PIK3R2	ENSPCOP00000018322	ENSPCOP00000018359	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.985
EGFR	PIK3R3	ENSPCOP00000018322	ENSPCOP00000008193	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.970