Your Input: | |
| | RECQL4 | RecQ like helicase 4. (842 aa) |
| | ENSPCOP00000005384 | annotation not available (103 aa) |
| | NABP1 | Nucleic acid binding protein 1. (126 aa) |
| | MACROH2A1 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | ENSPCOP00000005162 | WD_REPEATS_REGION domain-containing protein. (355 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (297 aa) |
| | ENSPCOP00000005069 | annotation not available (103 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (879 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | POT1 | Protection of telomeres 1. (600 aa) |
| | TERB1 | Telomere repeat binding bouquet formation protein 1. (592 aa) |
| | ENSPCOP00000004135 | Uncharacterized protein. (520 aa) |
| | DHX36 | HA2 domain-containing protein. (718 aa) |
| | NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (281 aa) |
| | ENSPCOP00000003703 | annotation not available (103 aa) |
| | CBX1 | Uncharacterized protein. (185 aa) |
| | NAT10 | RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa) |
| | ENSPCOP00000002972 | annotation not available (103 aa) |
| | ENSPCOP00000002858 | annotation not available (103 aa) |
| | ENSPCOP00000002776 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (330 aa) |
| | LOC105805699 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | MAJIN | Membrane anchored junction protein. (169 aa) |
| | ZSCAN4 | Uncharacterized protein. (433 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | NBN | Nbs1_C domain-containing protein. (429 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | TINF2 | TERF1 interacting nuclear factor 2. (451 aa) |
| | SETX | Senataxin. (2676 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (875 aa) |
| | MTA2 | Metastasis associated 1 family member 2. (668 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (285 aa) |
| | PML | Promyelocytic leukemia. (887 aa) |
| | TERF2 | Telomeric repeat binding factor 2. (542 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa) |
| | ORC2 | Origin recognition complex subunit 2. (546 aa) |
| | MEN1 | Menin 1. (616 aa) |
| | ZBTB10 | Zinc finger and BTB domain containing 10. (870 aa) |
| | SMG6 | SMG6 nonsense mediated mRNA decay factor. (1419 aa) |
| | HAT1 | Histone acetyltransferase 1. (394 aa) |
| | RNF8 | Ring finger protein 8. (488 aa) |
| | ATRX | ATRX chromatin remodeler. (2447 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1059 aa) |
| | CHD4 | Uncharacterized protein. (1899 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (643 aa) |
| | ENSPCOP00000013418 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (88 aa) |
| | ENSPCOP00000013227 | Uncharacterized protein. (169 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (435 aa) |
| | LOC105827239 | Uncharacterized protein. (181 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (369 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (738 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (231 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1806 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa) |
| | DCLRE1B | DNA cross-link repair 1B. (529 aa) |
| | ENSPCOP00000021297 | Uncharacterized protein; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (76 aa) |
| | TELO2 | Telomere maintenance 2. (836 aa) |
| | CDC73 | Cell division cycle 73. (429 aa) |
| | SSB | Small RNA binding exonuclease protection factor La. (367 aa) |
| | ENSPCOP00000022360 | FHA domain-containing protein. (60 aa) |
| | ORC3 | Origin recognition complex subunit 3. (712 aa) |
| | CBX5 | Chromobox 5. (191 aa) |
| | RBBP7 | RB binding protein 7, chromatin remodeling factor. (469 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1129 aa) |
| | ENSPCOP00000023982 | Chromo domain-containing protein. (156 aa) |
| | TNKS2 | Poly [ADP-ribose] polymerase. (1018 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (867 aa) |
| | ZNF827 | Zinc finger protein 827. (1082 aa) |
| | ENSPCOP00000024841 | Uncharacterized protein. (84 aa) |
| | SMC5 | SMC_N domain-containing protein. (1102 aa) |
| | MACROH2A2 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | RBBP4 | RB binding protein 4, chromatin remodeling factor. (425 aa) |
| | ENSPCOP00000025432 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (747 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (325 aa) |
| | TEN1 | Uncharacterized protein. (137 aa) |
| | TEP1 | Telomerase associated protein 1. (2562 aa) |
| | ATF7 | Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (483 aa) |
| | LOC105816693 | Histone H4. (103 aa) |
| | TERF2IP | TERF2 interacting protein. (393 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (247 aa) |
| | H3-4 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | CTC1 | CST telomere replication complex component 1. (1221 aa) |
| | H2AC1 | Histone H2A; Belongs to the histone H2A family. (131 aa) |
| | ENSPCOP00000028220 | annotation not available (103 aa) |
| | ENSPCOP00000028227 | annotation not available (103 aa) |
| | ENSPCOP00000028231 | Uncharacterized protein. (264 aa) |
| | LOC105805698 | Histone H4. (103 aa) |
| | GAR1 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (196 aa) |
| | DNA2 | Uncharacterized protein. (833 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (540 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (496 aa) |
| | ACD | ACD shelterin complex subunit and telomerase recruitment factor. (513 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2476 aa) |
| | TFIP11 | Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] (837 aa) |
| | TERB2 | Telomere repeat binding bouquet formation protein 2. (123 aa) |
| | ENSPCOP00000030829 | G-patch domain-containing protein. (169 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (267 aa) |
| | LOC105815151 | Uncharacterized protein. (913 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (933 aa) |
| | SIRT6 | Sirtuin 6. (305 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa) |
| | SUN2 | Sad1 and UNC84 domain containing 2. (734 aa) |
| | LRWD1 | Leucine rich repeats and WD repeat domain containing 1. (646 aa) |
| | LOC105817821 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (689 aa) |
| | CCDC155 | Coiled-coil domain containing 155. (567 aa) |
| | GATAD2B | GATA zinc finger domain containing 2B. (481 aa) |
| | LOC105819903 | Uncharacterized protein. (400 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa) |
| | ZBTB48 | Zinc finger and BTB domain containing 48. (688 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3419 aa) |
| | RAD51 | RAD51 recombinase; Belongs to the RecA family. (340 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1974 aa) |
| | NABP2 | Nucleic acid binding protein 2. (211 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa) |
| | LOC105805697 | Histone H4. (103 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (868 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (677 aa) |
