node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACD | CTC1 | ENSPCOP00000030285 | ENSPCOP00000027978 | ACD shelterin complex subunit and telomerase recruitment factor. | CST telomere replication complex component 1. | 0.827 |
ACD | ENSPCOP00000002776 | ENSPCOP00000030285 | ENSPCOP00000002776 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.963 |
ACD | ENSPCOP00000025432 | ENSPCOP00000030285 | ENSPCOP00000025432 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.963 |
ACD | POT1 | ENSPCOP00000030285 | ENSPCOP00000004523 | ACD shelterin complex subunit and telomerase recruitment factor. | Protection of telomeres 1. | 0.998 |
ACD | STN1 | ENSPCOP00000030285 | ENSPCOP00000012196 | ACD shelterin complex subunit and telomerase recruitment factor. | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. | 0.900 |
ACD | TEN1 | ENSPCOP00000030285 | ENSPCOP00000026041 | ACD shelterin complex subunit and telomerase recruitment factor. | Uncharacterized protein. | 0.792 |
ACD | TERF1 | ENSPCOP00000030285 | ENSPCOP00000020972 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. | 0.991 |
ACD | TERF2 | ENSPCOP00000030285 | ENSPCOP00000020164 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomeric repeat binding factor 2. | 0.992 |
ACD | TINF2 | ENSPCOP00000030285 | ENSPCOP00000000492 | ACD shelterin complex subunit and telomerase recruitment factor. | TERF1 interacting nuclear factor 2. | 0.998 |
CTC1 | ACD | ENSPCOP00000027978 | ENSPCOP00000030285 | CST telomere replication complex component 1. | ACD shelterin complex subunit and telomerase recruitment factor. | 0.827 |
CTC1 | POT1 | ENSPCOP00000027978 | ENSPCOP00000004523 | CST telomere replication complex component 1. | Protection of telomeres 1. | 0.921 |
CTC1 | STN1 | ENSPCOP00000027978 | ENSPCOP00000012196 | CST telomere replication complex component 1. | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. | 0.997 |
CTC1 | TEN1 | ENSPCOP00000027978 | ENSPCOP00000026041 | CST telomere replication complex component 1. | Uncharacterized protein. | 0.997 |
CTC1 | TERB1 | ENSPCOP00000027978 | ENSPCOP00000004278 | CST telomere replication complex component 1. | Telomere repeat binding bouquet formation protein 1. | 0.606 |
CTC1 | TERF1 | ENSPCOP00000027978 | ENSPCOP00000020972 | CST telomere replication complex component 1. | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. | 0.861 |
CTC1 | TERF2 | ENSPCOP00000027978 | ENSPCOP00000020164 | CST telomere replication complex component 1. | Telomeric repeat binding factor 2. | 0.806 |
CTC1 | TINF2 | ENSPCOP00000027978 | ENSPCOP00000000492 | CST telomere replication complex component 1. | TERF1 interacting nuclear factor 2. | 0.894 |
ENSPCOP00000002776 | ACD | ENSPCOP00000002776 | ENSPCOP00000030285 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | ACD shelterin complex subunit and telomerase recruitment factor. | 0.963 |
ENSPCOP00000002776 | ENSPCOP00000025432 | ENSPCOP00000002776 | ENSPCOP00000025432 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.942 |
ENSPCOP00000002776 | LOC105817821 | ENSPCOP00000002776 | ENSPCOP00000009690 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. | 0.838 |