STRINGSTRING
FLT1 FLT1 NRP1 NRP1 PRL PRL TIE1 TIE1 CCL26 CCL26 TGFBR1 TGFBR1 TNFSF12 TNFSF12 PROK1 PROK1 AGTR1 AGTR1 ENG ENG VEGFC VEGFC ATOH8 ATOH8 DBH DBH KRIT1 KRIT1 ACVRL1 ACVRL1 VEGFA VEGFA CYBA CYBA F3 F3 PLXNB3 PLXNB3 PLCG1 PLCG1 THBS1 THBS1 CAV1 CAV1 MYDGF MYDGF ALDH1A2 ALDH1A2 ARG1 ARG1 TNMD TNMD NF1 NF1 FGF7 FGF7 GHSR GHSR CAV2 CAV2 SP1 SP1 THBS4 THBS4 LOC105822688 LOC105822688 SIRT1 SIRT1 AGGF1 AGGF1 GHRL GHRL BMP4 BMP4 BMP6 BMP6 SYNJ2BP SYNJ2BP AKT3 AKT3 GDF2 GDF2 PDCD10 PDCD10 AKT1 AKT1 ECM1 ECM1 PRKCA PRKCA ADAM17 ADAM17 HTR2B HTR2B STAT3 STAT3 PIK3CD PIK3CD IGF2 IGF2 BMP2 BMP2 LRG1 LRG1 ARNT ARNT ATP5IF1 ATP5IF1 VASH1 VASH1 SIRT6 SIRT6 VEGFD VEGFD AIMP1 AIMP1 APLN APLN NRARP NRARP FGF10 FGF10 SULF1 SULF1 EMC10 EMC10 ITGA4 ITGA4 JCAD JCAD GATA2 GATA2 LOC105822640 LOC105822640 PRKD1 PRKD1 FGFR1 FGFR1 APLNR APLNR MMRN2 MMRN2 PDGFB PDGFB CCL24 CCL24 DLL4 DLL4 HMOX1 HMOX1 ZNF580 ZNF580 HIF1A HIF1A PDPK1 PDPK1 ANG ANG KDR KDR NRAS NRAS TBC1D31 TBC1D31 LEP LEP NR4A1 NR4A1 CXCL12 CXCL12 EGR3 EGR3 WNT5A WNT5A STAT1 STAT1 IL10 IL10 XDH XDH VEGFB VEGFB TEK TEK PTPRM PTPRM MEF2C MEF2C COL4A3 COL4A3 ENSPCOP00000009588 ENSPCOP00000009588 FLT4 FLT4 RPTOR RPTOR PGF PGF APOE APOE PPP1R16B PPP1R16B ATP5F1A ATP5F1A MDK MDK APELA APELA IL12B IL12B CNMD CNMD VASH2 VASH2 PRKD2 PRKD2 PROX1 PROX1 NGFR NGFR EGF EGF BMPR2 BMPR2 TNF TNF ALOX5 ALOX5 SPARC SPARC IL12A IL12A RGCC RGCC NRP2 NRP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
PRLProlactin. (231 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1143 aa)
CCL26C-C motif chemokine. (92 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (421 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (249 aa)
PROK1Prokineticin 1. (105 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
ENGEndoglin. (657 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (367 aa)
ATOH8Atonal bHLH transcription factor 8. (313 aa)
DBHDopamine beta-hydroxylase. (620 aa)
KRIT1ANK_REP_REGION domain-containing protein. (723 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
CYBACytochrome b-245 alpha chain. (129 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (294 aa)
PLXNB3Plexin B3. (1936 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1304 aa)
THBS1Thrombospondin 1. (1185 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
MYDGFMyeloid derived growth factor. (173 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
ARG1Arginase. (229 aa)
TNMDTenomodulin. (320 aa)
NF1Neurofibromin 1. (2841 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (364 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
SP1Sp1 transcription factor. (788 aa)
THBS4Thrombospondin 4. (959 aa)
LOC105822688Uncharacterized protein. (54 aa)
SIRT1Sirtuin 1. (743 aa)
AGGF1Uncharacterized protein. (717 aa)
GHRLGhrelin and obestatin prepropeptide. (116 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
BMP6Bone morphogenetic protein 6. (509 aa)
SYNJ2BPSynaptojanin 2 binding protein. (134 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GDF2Growth differentiation factor 2. (427 aa)
PDCD10Programmed cell death 10. (186 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ECM1Extracellular matrix protein 1. (570 aa)
PRKCAUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa)
ADAM17ADAM metallopeptidase domain 17. (757 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
STAT3Signal transducer and activator of transcription. (796 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
IGF2Insulin like growth factor 2. (236 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (748 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (106 aa)
VASH1Vasohibin 1. (363 aa)
SIRT6Sirtuin 6. (305 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (319 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (283 aa)
APLNApelin. (77 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SULF1Sulfatase 1. (863 aa)
EMC10ER membrane protein complex subunit 10. (261 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (964 aa)
JCADJunctional cadherin 5 associated. (1332 aa)
GATA2GATA binding protein 2. (445 aa)
LOC105822640Integrin beta; Belongs to the integrin beta chain family. (454 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (860 aa)
FGFR1Fibroblast growth factor receptor. (846 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
MMRN2Multimerin 2. (948 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
ZNF580Zinc finger protein 580. (172 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
ANGAngiogenin; Belongs to the pancreatic ribonuclease family. (146 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
TBC1D31TBC1 domain family member 31. (1062 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (598 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (159 aa)
EGR3Early growth response 3. (387 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
STAT1Signal transducer and activator of transcription. (794 aa)
IL10Interleukin 10. (178 aa)
XDHXanthine dehydrogenase. (1313 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1440 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
COL4A3Collagen type IV alpha 3 chain. (1545 aa)
ENSPCOP00000009588Uncharacterized protein. (316 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1341 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1281 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (220 aa)
APOEApolipoprotein E. (314 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (568 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (571 aa)
MDKMidkine. (143 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (326 aa)
CNMDChondromodulin. (287 aa)
VASH2Vasohibin 2. (355 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
PROX1Prospero homeobox 1. (737 aa)
NGFRNerve growth factor receptor. (429 aa)
EGFEpidermal growth factor. (1132 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
ALOX5Arachidonate 5-lipoxygenase. (675 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
RGCCRegulator of cell cycle. (137 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (932 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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