74 items (Propithecus coquereli) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	WNK1	WNK lysine deficient protein kinase 1. (2808 aa)
	GRP	Gastrin releasing peptide. (137 aa)
	COMMD1	Copper metabolism domain containing 1. (189 aa)
	NKX2-5	NK2 homeobox 5. (324 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (910 aa)
	FGF12	Fibroblast growth factor 12; Belongs to the heparin-binding growth factors family. (208 aa)
	ENSPCOP00000014148	Uncharacterized protein. (733 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1204 aa)
	SLC8A1	Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (974 aa)
	FGF14	Fibroblast growth factor 14; Belongs to the heparin-binding growth factors family. (217 aa)
	ATP1B1	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
	SCN2B	Sodium voltage-gated channel beta subunit 2. (215 aa)
	PER1	Period circadian regulator 1. (1292 aa)
	MLLT6	MLLT6, PHD finger containing. (1092 aa)
	NOS3	Nitric oxide synthase 3. (994 aa)
	NETO2	Neuropilin and tolloid like 2. (525 aa)
	BPIFA1	BPI fold containing family A member 1. (259 aa)
	KLHL24	Kelch like family member 24. (600 aa)
	SCN5A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2017 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1600 aa)
	FXYD2	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (66 aa)
	STOM	Stomatin. (288 aa)
	SPTBN4	Spectrin beta chain; Belongs to the spectrin family. (2533 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (402 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
	WNK4	WNK lysine deficient protein kinase 4. (1242 aa)
	PKP2	Plakophilin 2. (838 aa)
	SLMAP	Sarcolemma associated protein. (828 aa)
	ANK3	Ankyrin 3. (4372 aa)
	CNTN1	Contactin 1. (1018 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9. (693 aa)
	GLRX	Glutaredoxin. (106 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (545 aa)
	NKAIN3	Sodium/potassium transporting ATPase interacting 3. (197 aa)
	ATP1B3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
	FGF11	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
	NOS1	Nitric oxide synthase; Produces nitric oxide (NO). (1434 aa)
	DMPK	DM1 protein kinase. (630 aa)
	CHP1	Calcineurin like EF-hand protein 1. (201 aa)
	SCN4B	Sodium voltage-gated channel beta subunit 4. (225 aa)
	ENSPCOP00000020463	Uncharacterized protein. (49 aa)
	CAMK2D	Calcium/calmodulin dependent protein kinase II delta. (503 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (409 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	RANGRF	RAN guanine nucleotide release factor. (186 aa)
	WNK3	WNK lysine deficient protein kinase 3. (1791 aa)
	PRSS8	Serine protease 8; Belongs to the peptidase S1 family. (341 aa)
	NEDD4L	NEDD4 like E3 ubiquitin protein ligase. (1263 aa)
	AHCYL1	Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
	WNK2	WNK lysine deficient protein kinase 2. (2211 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	DNM2	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
	NETO1	Neuropilin and tolloid like 1. (459 aa)
	NKAIN1	Sodium/potassium transporting ATPase interacting 1. (207 aa)
	PRKCE	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
	YWHAH	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
	ENSPCOP00000027120	Uncharacterized protein. (1243 aa)
	FXYD1	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
	DRD4	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (333 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	SNTA1	Syntrophin alpha 1. (505 aa)
	SCN1B	Sodium voltage-gated channel beta subunit 1. (218 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	CHP2	Calcineurin like EF-hand protein 2. (196 aa)
	ENSPCOP00000030414	Uncharacterized protein. (347 aa)
	ENSPCOP00000030822	Uncharacterized protein. (911 aa)
	NEDD4	NEDD4 E3 ubiquitin protein ligase. (1320 aa)
	TESC	Tescalcin. (236 aa)
	PTPN3	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (914 aa)
	HECW2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1520 aa)
	STK39	Serine/threonine kinase 39. (522 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHCYL1	GLRX	ENSPCOP00000025492	ENSPCOP00000016060	Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family.	Glutaredoxin.	0.618
AKT1	CAV3	ENSPCOP00000028969	ENSPCOP00000004480	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.482
AKT1	NEDD4	ENSPCOP00000028969	ENSPCOP00000031040	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	NEDD4 E3 ubiquitin protein ligase.	0.497
AKT1	NKX2-5	ENSPCOP00000028969	ENSPCOP00000015558	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	NK2 homeobox 5.	0.415
AKT1	NOS1	ENSPCOP00000028969	ENSPCOP00000019524	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nitric oxide synthase; Produces nitric oxide (NO).	0.918
AKT1	NOS3	ENSPCOP00000028969	ENSPCOP00000009840	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nitric oxide synthase 3.	0.980
AKT1	SLC9A1	ENSPCOP00000028969	ENSPCOP00000031786	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.443
AKT1	TGFB1	ENSPCOP00000028969	ENSPCOP00000023065	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.653
AKT1	YWHAH	ENSPCOP00000028969	ENSPCOP00000026392	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family.	0.524
ANK3	CNTN1	ENSPCOP00000015809	ENSPCOP00000015893	Ankyrin 3.	Contactin 1.	0.596
ANK3	COMMD1	ENSPCOP00000015809	ENSPCOP00000000788	Ankyrin 3.	Copper metabolism domain containing 1.	0.435
ANK3	DLG1	ENSPCOP00000015809	ENSPCOP00000015085	Ankyrin 3.	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	0.415
ANK3	SCN5A	ENSPCOP00000015809	ENSPCOP00000006360	Ankyrin 3.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.743
ANK3	SPTBN4	ENSPCOP00000015809	ENSPCOP00000002884	Ankyrin 3.	Spectrin beta chain; Belongs to the spectrin family.	0.977
ATP1B1	ATP1B2	ENSPCOP00000012223	ENSPCOP00000032107	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.942
ATP1B1	ATP1B3	ENSPCOP00000012223	ENSPCOP00000018983	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.926
ATP1B1	ATP2B4	ENSPCOP00000012223	ENSPCOP00000014127	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.649
ATP1B1	ENSPCOP00000020463	ENSPCOP00000012223	ENSPCOP00000020463	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Uncharacterized protein.	0.464
ATP1B1	FXYD1	ENSPCOP00000012223	ENSPCOP00000027189	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.877
ATP1B1	FXYD2	ENSPCOP00000012223	ENSPCOP00000003648	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.998