47 items (Propithecus coquereli) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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	CSF1	Colony stimulating factor 1. (438 aa)
	EEF2K	Eukaryotic elongation factor 2 kinase. (725 aa)
	BVES	Blood vessel epicardial substance. (360 aa)
	BCL2	BCL2 apoptosis regulator. (234 aa)
	CX3CL1	C-X3-C motif chemokine ligand 1. (405 aa)
	CX3CR1	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1317 aa)
	PPIF	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
	SLC26A5	Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (650 aa)
	HK2	Hexokinase 2. (841 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (224 aa)
	ROCK2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1361 aa)
	CASR	Calcium sensing receptor. (1076 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	ENSPCOP00000008878	Uncharacterized protein. (329 aa)
	CIB1	Calcium and integrin binding 1. (191 aa)
	P2RX2	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (473 aa)
	PANX1	Pannexin; Structural component of the gap junctions and the hemichannels. (427 aa)
	SLC8A2	Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (926 aa)
	RNLS	Renalase, FAD dependent amine oxidase. (342 aa)
	MLYCD	Malonyl-CoA decarboxylase. (498 aa)
	ABRAXAS2	Abraxas 2, BRISC complex subunit. (415 aa)
	FAIM2	Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (316 aa)
	HYOU1	Hypoxia up-regulated 1. (997 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (613 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (270 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (402 aa)
	NOL3	Nucleolar protein 3. (204 aa)
	ENSPCOP00000002148	Uncharacterized protein. (118 aa)
	CPEB4	Cytoplasmic polyadenylation element binding protein 4. (729 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
	STUB1	STIP1 homology and U-box containing protein 1. (304 aa)
	PANX2	Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family. (667 aa)
	PINK1	PTEN induced kinase 1. (581 aa)
	FN1	Fibronectin 1. (2290 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
	MAP2K6	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (345 aa)
	CSF1R	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (964 aa)
	REST	Uncharacterized protein. (1018 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (967 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (406 aa)
	PER2	Period circadian regulator 2. (1265 aa)
	ENSPCOP00000031233	Uncharacterized protein. (318 aa)
	MAP2K3	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABRAXAS2	TP53	ENSPCOP00000005647	ENSPCOP00000031758	Abraxas 2, BRISC complex subunit.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.561
AIFM1	BCL2	ENSPCOP00000003513	ENSPCOP00000020794	Apoptosis inducing factor mitochondria associated 1.	BCL2 apoptosis regulator.	0.672
AIFM1	CASP9	ENSPCOP00000003513	ENSPCOP00000029367	Apoptosis inducing factor mitochondria associated 1.	Caspase 9; Belongs to the peptidase C14A family.	0.558
AIFM1	PPIF	ENSPCOP00000003513	ENSPCOP00000015002	Apoptosis inducing factor mitochondria associated 1.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.876
AIFM1	TP53	ENSPCOP00000003513	ENSPCOP00000031758	Apoptosis inducing factor mitochondria associated 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.464
BCL2	AIFM1	ENSPCOP00000020794	ENSPCOP00000003513	BCL2 apoptosis regulator.	Apoptosis inducing factor mitochondria associated 1.	0.672
BCL2	CASP9	ENSPCOP00000020794	ENSPCOP00000029367	BCL2 apoptosis regulator.	Caspase 9; Belongs to the peptidase C14A family.	0.733
BCL2	HK2	ENSPCOP00000020794	ENSPCOP00000012692	BCL2 apoptosis regulator.	Hexokinase 2.	0.432
BCL2	MAP3K5	ENSPCOP00000020794	ENSPCOP00000015848	BCL2 apoptosis regulator.	Mitogen-activated protein kinase kinase kinase 5.	0.421
BCL2	PINK1	ENSPCOP00000020794	ENSPCOP00000024544	BCL2 apoptosis regulator.	PTEN induced kinase 1.	0.754
BCL2	PPIF	ENSPCOP00000020794	ENSPCOP00000015002	BCL2 apoptosis regulator.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.712
BCL2	TP53	ENSPCOP00000020794	ENSPCOP00000031758	BCL2 apoptosis regulator.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.994
CASP9	AIFM1	ENSPCOP00000029367	ENSPCOP00000003513	Caspase 9; Belongs to the peptidase C14A family.	Apoptosis inducing factor mitochondria associated 1.	0.558
CASP9	BCL2	ENSPCOP00000029367	ENSPCOP00000020794	Caspase 9; Belongs to the peptidase C14A family.	BCL2 apoptosis regulator.	0.733
CASP9	PANX1	ENSPCOP00000029367	ENSPCOP00000006913	Caspase 9; Belongs to the peptidase C14A family.	Pannexin; Structural component of the gap junctions and the hemichannels.	0.479
CASP9	PTK2B	ENSPCOP00000029367	ENSPCOP00000027938	Caspase 9; Belongs to the peptidase C14A family.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.503
CASP9	ROCK2	ENSPCOP00000029367	ENSPCOP00000011832	Caspase 9; Belongs to the peptidase C14A family.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.568
CASP9	TP53	ENSPCOP00000029367	ENSPCOP00000031758	Caspase 9; Belongs to the peptidase C14A family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.744
CASR	ROCK2	ENSPCOP00000009624	ENSPCOP00000011832	Calcium sensing receptor.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.508
CAV1	CAV3	ENSPCOP00000025045	ENSPCOP00000004480	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.902