STRINGSTRING
DDB2 DDB2 TP53BP1 TP53BP1 MSH6 MSH6 DDB1 DDB1 SDE2 SDE2 DCLRE1A DCLRE1A PCNA PCNA POLH POLH LOC105817821 LOC105817821 ERCC2 ERCC2 RBBP8 RBBP8 ENSPCOP00000012342 ENSPCOP00000012342 LOC105811387 LOC105811387 MPG MPG POLD1 POLD1 NTHL1 NTHL1 XPA XPA PNKP PNKP APEX1 APEX1 EP300 EP300 TDG TDG ENSPCOP00000020030 ENSPCOP00000020030 MSH2 MSH2 XRCC5 XRCC5 RECQL4 RECQL4 REV1 REV1 ERCC4 ERCC4 POT1 POT1 NEIL3 NEIL3 ENSPCOP00000002676 ENSPCOP00000002676 POLI POLI CREBBP CREBBP FANCG FANCG DCLRE1B DCLRE1B RPA3 RPA3 NEIL2 NEIL2 RAD23A RAD23A ENSPCOP00000023392 ENSPCOP00000023392 XPC XPC ENSPCOP00000024882 ENSPCOP00000024882 POLQ POLQ XRCC1 XRCC1 POLB POLB UNG UNG ENSPCOP00000027398 ENSPCOP00000027398 OGG1 OGG1 XRCC6 XRCC6 NEIL1 NEIL1 POLK POLK ENSPCOP00000030730 ENSPCOP00000030730 TP63 TP63 SMC6 SMC6 AUNIP AUNIP SIRT6 SIRT6 RPS3 RPS3 ERCC1 ERCC1 CRY2 CRY2 RAD23B RAD23B MUTYH MUTYH RPA1 RPA1 BLM BLM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDB2Damage specific DNA binding protein 2. (426 aa)
TP53BP1Tumor protein p53 binding protein 1. (1974 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1229 aa)
DDB1Damage specific DNA binding protein 1. (1142 aa)
SDE2SDE2 telomere maintenance homolog. (286 aa)
DCLRE1ADRMBL domain-containing protein. (506 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
POLHDNA polymerase eta. (709 aa)
LOC105817821X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (689 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (681 aa)
RBBP8RB binding protein 8, endonuclease. (865 aa)
ENSPCOP00000012342RING-type domain-containing protein. (80 aa)
LOC105811387XRCC1_N domain-containing protein. (142 aa)
MPGN-methylpurine DNA glycosylase. (284 aa)
POLD1DNA polymerase. (1125 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (312 aa)
XPAXPA, DNA damage recognition and repair factor. (251 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (521 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
EP300E1A binding protein p300. (2424 aa)
TDGThymine DNA glycosylase. (256 aa)
ENSPCOP00000020030KH type-2 domain-containing protein. (93 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (868 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (677 aa)
RECQL4RecQ like helicase 4. (842 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1197 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (879 aa)
POT1Protection of telomeres 1. (600 aa)
NEIL3Nei like DNA glycosylase 3. (423 aa)
ENSPCOP00000002676Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (879 aa)
POLIDNA polymerase iota. (735 aa)
CREBBPCREB binding protein. (2449 aa)
FANCGFA complementation group G. (621 aa)
DCLRE1BDNA cross-link repair 1B. (529 aa)
RPA3Replication protein A3. (107 aa)
NEIL2Nei like DNA glycosylase 2. (217 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (365 aa)
ENSPCOP00000023392Uncharacterized protein. (157 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (867 aa)
ENSPCOP00000024882Ribosomal_S3_C domain-containing protein. (231 aa)
POLQDNA polymerase theta. (2280 aa)
XRCC1X-ray repair cross complementing 1. (598 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (333 aa)
UNGUracil DNA glycosylase. (261 aa)
ENSPCOP00000027398KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (281 aa)
OGG18-oxoguanine DNA glycosylase. (380 aa)
XRCC6X-ray repair cross complementing 6. (496 aa)
NEIL1Nei like DNA glycosylase 1. (390 aa)
POLKDNA polymerase kappa. (832 aa)
ENSPCOP00000030730Uncharacterized protein. (103 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
SMC6Structural maintenance of chromosomes 6. (933 aa)
AUNIPAurora kinase A and ninein interacting protein. (321 aa)
SIRT6Sirtuin 6. (305 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
CRY2Cryptochrome circadian regulator 2. (593 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (409 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (549 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
BLMBLM RecQ like helicase. (1352 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
Server load: low (28%) [HD]