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COA7 COA7 ENSPCOP00000000707 ENSPCOP00000000707 MYOC MYOC MICU1 MICU1 GOLPH3 GOLPH3 CHCHD10 CHCHD10 SIRT5 SIRT5 CEP89 CEP89 AIFM1 AIFM1 LOC105825287 LOC105825287 ARL2BP ARL2BP ENSPCOP00000004684 ENSPCOP00000004684 CPOX CPOX ENSPCOP00000004977 ENSPCOP00000004977 HAX1 HAX1 GFER GFER SUOX SUOX NME4 NME4 PNPT1 PNPT1 LOC105808296 LOC105808296 CDC25C CDC25C ENSPCOP00000009443 ENSPCOP00000009443 ENSPCOP00000009718 ENSPCOP00000009718 TIMM29 TIMM29 NDUFS5 NDUFS5 STOML2 STOML2 ALPL ALPL CHCHD7 CHCHD7 COX19 COX19 FKBP10 FKBP10 TRIAP1 TRIAP1 TIMM9 TIMM9 TIMM10 TIMM10 NDUFS1 NDUFS1 NLN NLN PANK2 PANK2 OPA1 OPA1 ENSPCOP00000015642 ENSPCOP00000015642 PRELID3B PRELID3B CHCHD5 CHCHD5 ENSPCOP00000016892 ENSPCOP00000016892 STAR STAR LOC105823121 LOC105823121 PRELID3A PRELID3A ENSPCOP00000018118 ENSPCOP00000018118 CIAPIN1 CIAPIN1 FGR FGR ARL2 ARL2 TRAP1 TRAP1 TIMM10B TIMM10B PRELID1 PRELID1 MICU2 MICU2 TIMM13 TIMM13 TIMM8A TIMM8A AK2 AK2 CHCHD4 CHCHD4 HTRA2 HTRA2 ENSPCOP00000023228 ENSPCOP00000023228 ENSPCOP00000023440 ENSPCOP00000023440 SHMT2 SHMT2 COX17 COX17 PINK1 PINK1 LYN LYN CHCHD2 CHCHD2 NDUFB7 NDUFB7 FBXL4 FBXL4 CMC4 CMC4 ENSPCOP00000025624 ENSPCOP00000025624 ENSPCOP00000026048 ENSPCOP00000026048 NDUFA8 NDUFA8 AGK AGK CLPB CLPB PRELID2 PRELID2 THOP1 THOP1 ENSPCOP00000027105 ENSPCOP00000027105 LOC105807375 LOC105807375 CCDC58 CCDC58 TIMM8B TIMM8B STMP1 STMP1 PARK7 PARK7 BLOC1S1 BLOC1S1 THEM4 THEM4 REXO2 REXO2 IMMT IMMT LOC105815609 LOC105815609
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
COA7Cytochrome c oxidase assembly factor 7 (putative). (231 aa)
ENSPCOP00000000707Uncharacterized protein. (139 aa)
MYOCMyocilin. (504 aa)
MICU1Mitochondrial calcium uptake 1. (475 aa)
GOLPH3Golgi phosphoprotein 3. (298 aa)
CHCHD10Coiled-coil-helix-coiled-coil-helix domain containing 10. (147 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (313 aa)
CEP89Centrosomal protein 89. (749 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
LOC105825287DJ-1_PfpI domain-containing protein. (189 aa)
ARL2BPARL2_Bind_BART domain-containing protein. (163 aa)
ENSPCOP00000004684Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CPOXCoproporphyrinogen oxidase. (443 aa)
ENSPCOP00000004977zf-Tim10_DDP domain-containing protein. (84 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (278 aa)
GFERSulfhydryl oxidase. (206 aa)
SUOXSulfite oxidase. (545 aa)
NME4Nucleoside diphosphate kinase. (187 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (672 aa)
LOC105808296PRELI/MSF1 domain-containing protein. (179 aa)
CDC25CCell division cycle 25C. (454 aa)
ENSPCOP00000009443Uncharacterized protein. (69 aa)
ENSPCOP00000009718ARL2_Bind_BART domain-containing protein. (80 aa)
TIMM29Translocase of inner mitochondrial membrane 29. (260 aa)
NDUFS5NADH:ubiquinone oxidoreductase subunit S5. (106 aa)
STOML2Stomatin like 2. (361 aa)
ALPLAlkaline phosphatase. (524 aa)
CHCHD7Coiled-coil-helix-coiled-coil-helix domain containing 7. (97 aa)
COX19Cytochrome c oxidase assembly factor COX19. (89 aa)
FKBP10Peptidylprolyl isomerase. (582 aa)
TRIAP1Uncharacterized protein. (76 aa)
TIMM9Translocase of inner mitochondrial membrane 9. (89 aa)
TIMM10Translocase of inner mitochondrial membrane 10. (90 aa)
NDUFS14Fe-4S Mo/W bis-MGD-type domain-containing protein. (274 aa)
NLNNeurolysin. (658 aa)
PANK2Pantothenate kinase 2. (551 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (997 aa)
ENSPCOP00000015642DJ-1_PfpI domain-containing protein. (175 aa)
PRELID3BPRELI/MSF1 domain-containing protein. (215 aa)
CHCHD5Coiled-coil-helix-coiled-coil-helix domain containing 5. (156 aa)
ENSPCOP00000016892ARL2_Bind_BART domain-containing protein. (150 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
LOC105823121Uncharacterized protein. (79 aa)
PRELID3APRELI domain containing 3A. (161 aa)
ENSPCOP00000018118Uncharacterized protein. (121 aa)
CIAPIN1Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] (312 aa)
FGRTyrosine-protein kinase. (495 aa)
ARL2ADP ribosylation factor like GTPase 2; Belongs to the small GTPase superfamily. Arf family. (184 aa)
TRAP1TNF receptor associated protein 1. (681 aa)
TIMM10Bzf-Tim10_DDP domain-containing protein. (101 aa)
PRELID1PRELI domain containing 1. (219 aa)
MICU2Mitochondrial calcium uptake 2. (374 aa)
TIMM13Translocase of inner mitochondrial membrane 13; Belongs to the small Tim family. (95 aa)
TIMM8ATranslocase of inner mitochondrial membrane 8A; Belongs to the small Tim family. (96 aa)
AK2Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (232 aa)
CHCHD4Coiled-coil-helix-coiled-coil-helix domain containing 4. (141 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
ENSPCOP00000023228Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (99 aa)
ENSPCOP00000023440Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (95 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
COX17Cytochrome c oxidase copper chaperone COX17. (63 aa)
PINK1PTEN induced kinase 1. (581 aa)
LYNTyrosine-protein kinase. (512 aa)
CHCHD2Uncharacterized protein. (153 aa)
NDUFB7NADH:ubiquinone oxidoreductase subunit B7. (137 aa)
FBXL4F-box and leucine rich repeat protein 4. (621 aa)
CMC4C-X9-C motif containing 4. (68 aa)
ENSPCOP00000025624Uncharacterized protein. (147 aa)
ENSPCOP00000026048ARL2_Bind_BART domain-containing protein. (109 aa)
NDUFA8NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (172 aa)
AGKAcylglycerol kinase. (410 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (707 aa)
PRELID2PRELI domain containing 2. (189 aa)
THOP1Thimet oligopeptidase 1. (687 aa)
ENSPCOP00000027105Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC105807375Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CCDC58Uncharacterized protein. (144 aa)
TIMM8BTranslocase of inner mitochondrial membrane 8 homolog B; Belongs to the small Tim family. (98 aa)
STMP1Short transmembrane mitochondrial protein 1. (47 aa)
PARK7DJ-1_PfpI domain-containing protein. (155 aa)
BLOC1S1Biogenesis of lysosomal organelles complex 1 subunit 1. (152 aa)
THEM4Thioesterase superfamily member 4. (202 aa)
REXO2RNA exonuclease 2. (195 aa)
IMMTMICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (758 aa)
LOC105815609Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (100 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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