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| | SIRT7 | Sirtuin 7. (400 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (867 aa) |
| | CDK2AP1 | Cyclin dependent kinase 2 associated protein 1. (96 aa) |
| | POLD3 | DNA polymerase delta 3, accessory subunit. (359 aa) |
| | ENSPCOP00000024841 | Uncharacterized protein. (84 aa) |
| | POLG2 | DNA polymerase gamma 2, accessory subunit. (465 aa) |
| | POLQ | DNA polymerase theta. (2280 aa) |
| | ENSPCOP00000024945 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (97 aa) |
| | NFIA | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (553 aa) |
| | RBBP4 | RB binding protein 4, chromatin remodeling factor. (425 aa) |
| | CHAF1A | Chromatin assembly factor 1 subunit A. (959 aa) |
| | SRPK2 | SRSF protein kinase 2. (698 aa) |
| | LIG3 | DNA ligase. (966 aa) |
| | DDX23 | DEAD-box helicase 23. (820 aa) |
| | ING5 | Uncharacterized protein. (342 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (333 aa) |
| | TOP1MT | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (503 aa) |
| | DTD1 | D-aminoacyl-tRNA deacylase. (209 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | CORT | Cortistatin. (105 aa) |
| | CENPS | Centromere protein S. (138 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | BOD1L1 | Biorientation of chromosomes in cell division 1 like 1. (3018 aa) |
| | PRIM2 | Uncharacterized protein. (158 aa) |
| | ZPR1 | Uncharacterized protein. (459 aa) |
| | POLN | DNA polymerase nu. (899 aa) |
| | LIG1 | DNA ligase. (916 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1007 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa) |
| | POLK | DNA polymerase kappa. (832 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (555 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (581 aa) |
| | TRAIP | TRAF interacting protein. (469 aa) |
| | NFIC | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (530 aa) |
| | RBMS1 | RNA binding motif single stranded interacting protein 1. (406 aa) |
| | POLE2 | DNA polymerase epsilon 2, accessory subunit. (439 aa) |
| | NUCKS1 | Nuclear casein kinase and cyclin dependent kinase substrate 1. (223 aa) |
| | RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa) |
| | DNA2 | Uncharacterized protein. (833 aa) |
| | RFC1 | Replication factor C subunit 1. (1113 aa) |
| | BAZ1A | Uncharacterized protein. (1366 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | RBM48 | RNA binding motif protein 48. (367 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (222 aa) |
| | GMNN | Uncharacterized protein. (210 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (853 aa) |
| | TWNK | Twinkle mtDNA helicase. (669 aa) |
| | DONSON | Downstream neighbor of SON. (564 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (998 aa) |
| | TTC38 | Tetratricopeptide repeat domain 38. (469 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | RAD51 | RAD51 recombinase; Belongs to the RecA family. (340 aa) |
| | MGME1 | Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (346 aa) |
| | ENSPCOP00000008190 | AAA domain-containing protein. (331 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3419 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa) |
| | SDE2 | SDE2 telomere maintenance homolog. (286 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (393 aa) |
| | NFIX | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (520 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | GINS1 | GINS complex subunit 1. (196 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1103 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (400 aa) |
| | POLH | DNA polymerase eta. (709 aa) |
| | LRWD1 | Leucine rich repeats and WD repeat domain containing 1. (646 aa) |
| | KIN | Kin17_mid domain-containing protein. (388 aa) |
| | LOC105811051 | Uncharacterized protein. (202 aa) |
| | ENSPCOP00000010852 | dUTPase domain-containing protein. (184 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1806 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (118 aa) |
| | NFIB | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa) |
| | WRNIP1 | WRN helicase interacting protein 1. (666 aa) |
| | DDX11 | DEAD/H-box helicase 11. (835 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1646 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (738 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (865 aa) |
| | NASP | Nuclear autoantigenic sperm protein. (695 aa) |
| | POLA1 | DNA polymerase. (1442 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (762 aa) |
| | RMI2 | RecQ mediated genome instability 2. (150 aa) |
| | DHX9 | DExH-box helicase 9. (1262 aa) |
| | ENSPCOP00000012888 | Kin17_mid domain-containing protein. (232 aa) |
| | GMNC | Geminin coiled-coil domain containing. (297 aa) |
| | FAM111A | Family with sequence similarity 111 member A. (613 aa) |
| | DBF4 | DBF4 zinc finger. (676 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (551 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (643 aa) |
| | TIMELESS | Timeless circadian regulator. (1204 aa) |
| | DUT | dUTPase domain-containing protein. (253 aa) |
| | NOC3L | Nucleolar complex protein 3 homolog. (715 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3120 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa) |
| | PTMS | Parathymosin. (145 aa) |
| | POLD1 | DNA polymerase. (1125 aa) |
| | DDX21 | DExD-box helicase 21. (758 aa) |
| | ENSPCOP00000015141 | DUF2439 domain-containing protein. (603 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (573 aa) |
| | GINS2 | GINS complex subunit 2. (151 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (511 aa) |
| | E4F1 | E4F transcription factor 1. (765 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | FANCM | FA complementation group M. (1953 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | LOC105815349 | Uncharacterized protein. (308 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1186 aa) |
| | WDR18 | WD repeat domain 18. (432 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | TICRR | TOPBP1 interacting checkpoint and replication regulator. (1912 aa) |
| | RECQL4 | RecQ like helicase 4. (842 aa) |
| | ENSPCOP00000005162 | WD_REPEATS_REGION domain-containing protein. (355 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1286 aa) |
| | PCLAF | PAF domain-containing protein. (65 aa) |
| | CHAF1B | Chromatin assembly factor 1 subunit B. (559 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | LOC105817292 | Kin17_mid domain-containing protein. (393 aa) |
| | DDX50 | DExD-box helicase 50. (595 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1381 aa) |
| | RRM2 | Ribonucleotide reductase regulatory subunit M2. (386 aa) |
| | FBH1 | F-box DNA helicase 1. (1056 aa) |
| | ING4 | Inhibitor of growth protein. (248 aa) |
| | SMIM26 | Small integral membrane protein 26. (87 aa) |
| | HELB | DNA helicase B. (763 aa) |
| | GRWD1 | Glutamate rich WD repeat containing 1. (447 aa) |
| | THOC1 | THO complex 1. (655 aa) |
| | NRM | Nurim. (262 aa) |
| | TM4SF19 | Uncharacterized protein. (209 aa) |
| | SUPT16H | SPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa) |
| | RTF2 | Replication termination factor 2. (306 aa) |
| | LOC105812780 | Uncharacterized protein. (433 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | CCDC88A | Coiled-coil domain containing 88A. (1722 aa) |
| | ZRANB3 | Zinc finger RANBP2-type containing 3. (999 aa) |
| | RNASEH2A | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (300 aa) |
| | RRM2B | Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa) |
| | RPAIN | RPA interacting protein. (225 aa) |
| | ENSPCOP00000000763 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (268 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (769 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | ETAA1 | ETAA1 activator of ATR kinase. (889 aa) |
| | KHDC3L | KH domain containing 3 like, subcortical maternal complex member. (202 aa) |
| | BLM | BLM RecQ like helicase. (1352 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | OOEP | Oocyte expressed protein. (149 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (988 aa) |
| | RNASEH1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (266 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (599 aa) |
| | ENSPCOP00000015888 | Uncharacterized protein. (319 aa) |
| | ATRX | ATRX chromatin remodeler. (2447 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa) |
| | ENSPCOP00000016169 | AAA_12 domain-containing protein. (240 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1274 aa) |
| | ENSPCOP00000016685 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (203 aa) |
| | REPIN1 | Replication initiator 1. (621 aa) |
| | ENSPCOP00000017047 | dUTPase domain-containing protein. (164 aa) |
| | CHEK1 | Checkpoint kinase 1. (454 aa) |
| | RFC4 | Replication factor C subunit 4. (365 aa) |
| | RFC5 | AAA domain-containing protein. (338 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | STRA8 | Stimulated by retinoic acid 8. (361 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (521 aa) |
| | MCMBP | Minichromosome maintenance complex binding protein. (600 aa) |
| | DERPC | DERPC proline and glycine rich nuclear protein. (529 aa) |
| | ALYREF | Aly/REF export factor. (263 aa) |
| | SSBP1 | Single stranded DNA binding protein 1. (148 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (374 aa) |
| | DNAJC2 | DnaJ heat shock protein family (Hsp40) member C2. (621 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (828 aa) |
| | LOC105824103 | Uncharacterized protein. (430 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | ORC2 | Origin recognition complex subunit 2. (546 aa) |
| | RBBP6 | RB binding protein 6, ubiquitin ligase. (1790 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (633 aa) |
| | KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (550 aa) |
| | HMGA1 | High mobility group AT-hook 1. (107 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (782 aa) |
| | POLG | DNA polymerase gamma, catalytic subunit. (1224 aa) |
| | POLI | DNA polymerase iota. (735 aa) |
| | TBRG1 | Transforming growth factor beta regulator 1. (411 aa) |
| | RPA3 | Replication protein A3. (107 aa) |
| | CENPX | Uncharacterized protein. (79 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1394 aa) |
| | FAM111B | Family with sequence similarity 111 member B. (729 aa) |
| | SSRP1 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa) |
| | ORC3 | Origin recognition complex subunit 3. (712 aa) |
| | DTL | Denticleless E3 ubiquitin protein ligase homolog. (784 aa) |
| | CDC34 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (235 aa) |
| | RBBP7 | RB binding protein 7, chromatin remodeling factor. (469 aa) |
| | RPA2 | Replication protein A2. (306 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1129 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (504 aa) |
| | CDC45 | Cell division cycle 45. (591 aa) |
| | CDK9 | Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa) |
| | DNAJA3 | DnaJ heat shock protein family (Hsp40) member A3. (429 aa) |
