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| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (988 aa) |
| | OOEP | Oocyte expressed protein. (149 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | BLM | BLM RecQ like helicase. (1352 aa) |
| | KHDC3L | KH domain containing 3 like, subcortical maternal complex member. (202 aa) |
| | ETAA1 | ETAA1 activator of ATR kinase. (889 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (769 aa) |
| | ENSPCOP00000000763 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (268 aa) |
| | RPAIN | RPA interacting protein. (225 aa) |
| | RRM2B | Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa) |
| | ZRANB3 | Zinc finger RANBP2-type containing 3. (999 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | LOC105812780 | Uncharacterized protein. (433 aa) |
| | RTF2 | Replication termination factor 2. (306 aa) |
| | NRM | Nurim. (262 aa) |
| | THOC1 | THO complex 1. (655 aa) |
| | HELB | DNA helicase B. (763 aa) |
| | FBH1 | F-box DNA helicase 1. (1056 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1381 aa) |
| | DDX50 | DExD-box helicase 50. (595 aa) |
| | RECQL4 | RecQ like helicase 4. (842 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | WDR18 | WD repeat domain 18. (432 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1186 aa) |
| | LOC105815349 | Uncharacterized protein. (308 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | FANCM | FA complementation group M. (1953 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | GMNN | Uncharacterized protein. (210 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (853 aa) |
| | TWNK | Twinkle mtDNA helicase. (669 aa) |
| | DONSON | Downstream neighbor of SON. (564 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | RAD51 | RAD51 recombinase; Belongs to the RecA family. (340 aa) |
| | MGME1 | Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (346 aa) |
| | ENSPCOP00000008190 | AAA domain-containing protein. (331 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3419 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | GINS1 | GINS complex subunit 1. (196 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1103 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (400 aa) |
| | LRWD1 | Leucine rich repeats and WD repeat domain containing 1. (646 aa) |
| | LOC105811051 | Uncharacterized protein. (202 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (118 aa) |
| | WRNIP1 | WRN helicase interacting protein 1. (666 aa) |
| | DDX11 | DEAD/H-box helicase 11. (835 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1646 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (738 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (865 aa) |
| | POLA1 | DNA polymerase. (1442 aa) |
| | GMNC | Geminin coiled-coil domain containing. (297 aa) |
| | FAM111A | Family with sequence similarity 111 member A. (613 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (551 aa) |
| | TIMELESS | Timeless circadian regulator. (1204 aa) |
| | NOC3L | Nucleolar complex protein 3 homolog. (715 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3120 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa) |
| | POLD1 | DNA polymerase. (1125 aa) |
| | DDX21 | DExD-box helicase 21. (758 aa) |
| | ENSPCOP00000015141 | DUF2439 domain-containing protein. (603 aa) |
| | GINS2 | GINS complex subunit 2. (151 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (511 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (599 aa) |
| | ENSPCOP00000015888 | Uncharacterized protein. (319 aa) |
| | ATRX | ATRX chromatin remodeler. (2447 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa) |
| | ENSPCOP00000016169 | AAA_12 domain-containing protein. (240 aa) |
| | ENSPCOP00000016685 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (203 aa) |
| | RFC4 | Replication factor C subunit 4. (365 aa) |
| | RFC5 | AAA domain-containing protein. (338 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (521 aa) |
| | MCMBP | Minichromosome maintenance complex binding protein. (600 aa) |
| | ALYREF | Aly/REF export factor. (263 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (374 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (828 aa) |
| | LOC105824103 | Uncharacterized protein. (430 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | ORC2 | Origin recognition complex subunit 2. (546 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (633 aa) |
| | HMGA1 | High mobility group AT-hook 1. (107 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (782 aa) |
| | POLG | DNA polymerase gamma, catalytic subunit. (1224 aa) |
| | CENPX | Uncharacterized protein. (79 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1394 aa) |
| | ORC3 | Origin recognition complex subunit 3. (712 aa) |
| | CDC34 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (235 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1129 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (504 aa) |
| | CDC45 | Cell division cycle 45. (591 aa) |
| | CDK9 | Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa) |
| | DNAJA3 | DnaJ heat shock protein family (Hsp40) member A3. (429 aa) |
| | SIRT7 | Sirtuin 7. (400 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (867 aa) |
| | CDK2AP1 | Cyclin dependent kinase 2 associated protein 1. (96 aa) |
| | POLD3 | DNA polymerase delta 3, accessory subunit. (359 aa) |
| | ENSPCOP00000024841 | Uncharacterized protein. (84 aa) |
| | POLG2 | DNA polymerase gamma 2, accessory subunit. (465 aa) |
| | POLQ | DNA polymerase theta. (2280 aa) |
| | ENSPCOP00000024945 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (97 aa) |
| | SRPK2 | SRSF protein kinase 2. (698 aa) |
| | LIG3 | DNA ligase. (966 aa) |
| | DDX23 | DEAD-box helicase 23. (820 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (333 aa) |
| | RFC1 | Replication factor C subunit 1. (1113 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (222 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | BAZ1A | Uncharacterized protein. (1366 aa) |
| | DNA2 | Uncharacterized protein. (833 aa) |
| | RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa) |
| | NUCKS1 | Nuclear casein kinase and cyclin dependent kinase substrate 1. (223 aa) |
| | POLE2 | DNA polymerase epsilon 2, accessory subunit. (439 aa) |
| | TRAIP | TRAF interacting protein. (469 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (555 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1007 aa) |
| | LIG1 | DNA ligase. (916 aa) |
| | POLN | DNA polymerase nu. (899 aa) |
| | ZPR1 | Uncharacterized protein. (459 aa) |
| | PRIM2 | Uncharacterized protein. (158 aa) |
| | BOD1L1 | Biorientation of chromosomes in cell division 1 like 1. (3018 aa) |
| | CENPS | Centromere protein S. (138 aa) |
| | CORT | Cortistatin. (105 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
