STRINGSTRING
XRCC6 XRCC6 ERCC1 ERCC1 ERCC8 ERCC8 PSMD14 PSMD14 RNF8 RNF8 PNKP PNKP ATM ATM UVRAG UVRAG ATP23 ATP23 DCLRE1B DCLRE1B POLQ POLQ LIG3 LIG3 POLB POLB HMCES HMCES NHEJ1 NHEJ1 DNTT DNTT ZBTB7A ZBTB7A HELQ HELQ KDM2A KDM2A MLH1 MLH1 ERCC4 ERCC4 XRCC4 XRCC4 APLF APLF POLM POLM XRCC5 XRCC5 PRPF19 PRPF19 PRKDC PRKDC LOC105815349 LOC105815349 ERCC6 ERCC6 CYREN CYREN TP53BP1 TP53BP1 DCLRE1A DCLRE1A LOC105817821 LOC105817821 POLA1 POLA1 IFFO2 IFFO2 POLL POLL IFFO1 IFFO1 PAXX PAXX ENSPCOP00000015888 ENSPCOP00000015888
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
XRCC6X-ray repair cross complementing 6. (496 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (274 aa)
RNF8Ring finger protein 8. (488 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (521 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2635 aa)
UVRAGUV radiation resistance associated. (701 aa)
ATP23Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (246 aa)
DCLRE1BDNA cross-link repair 1B. (529 aa)
POLQDNA polymerase theta. (2280 aa)
LIG3DNA ligase. (966 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (333 aa)
HMCESAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (300 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (511 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (582 aa)
HELQHelicase, POLQ like. (914 aa)
KDM2ALysine demethylase 2A. (1153 aa)
MLH1MutL homolog 1. (757 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (879 aa)
XRCC4X-ray repair cross complementing 4. (297 aa)
APLFFHA_2 domain-containing protein. (276 aa)
POLMDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (491 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (677 aa)
PRPF19Pre-mRNA processing factor 19. (472 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa)
LOC105815349Uncharacterized protein. (308 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1488 aa)
CYRENCell cycle regulator of NHEJ. (151 aa)
TP53BP1Tumor protein p53 binding protein 1. (1974 aa)
DCLRE1ADRMBL domain-containing protein. (506 aa)
LOC105817821X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (689 aa)
POLA1DNA polymerase. (1442 aa)
IFFO2Intermediate filament family orphan 2; Belongs to the intermediate filament family. (516 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (573 aa)
IFFO1Intermediate filament family orphan 1; Belongs to the intermediate filament family. (575 aa)
PAXXPAXX non-homologous end joining factor. (203 aa)
ENSPCOP00000015888Uncharacterized protein. (319 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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