STRINGSTRING
NRROS NRROS LRRC32 LRRC32 USP9X USP9X TP53 TP53 BAMBI BAMBI FMOD FMOD MTMR4 MTMR4 SKI SKI HPGD HPGD ZFYVE9 ZFYVE9 ENSPCOP00000030534 ENSPCOP00000030534 STAT3 STAT3 LTBP2 LTBP2 WFIKKN2 WFIKKN2 SIRT1 SIRT1 CAV2 CAV2 CHST11 CHST11 PTK2 PTK2 SMAD4 SMAD4 FOXH1 FOXH1 FNTA FNTA FLCN FLCN TGFB1 TGFB1 ACVRL1 ACVRL1 SMAD3 SMAD3 CITED2 CITED2 TGFBR3L TGFBR3L FUT8 FUT8 ENG ENG ONECUT2 ONECUT2 ITGA8 ITGA8 PML PML GDF5 GDF5 LTBP3 LTBP3 CDH5 CDH5 SMAD9 SMAD9 TGFBR1 TGFBR1 SRC SRC ITGB8 ITGB8 ACVR1 ACVR1 TGFBR3 TGFBR3 NLK NLK MSTN MSTN FSHB FSHB PXN PXN TWSG1 TWSG1 AMHR2 AMHR2 FERMT2 FERMT2 BMPR1A BMPR1A USP15 USP15 FURIN FURIN PARP1 PARP1 LOC105824854 LOC105824854 APPL2 APPL2 ID1 ID1 NODAL NODAL GDF10 GDF10 APPL1 APPL1 TGFBRAP1 TGFBRAP1 DUSP22 DUSP22 ZMIZ1 ZMIZ1 TGFB3 TGFB3 LOC105824853 LOC105824853 SMAD1 SMAD1 CITED1 CITED1 GLG1 GLG1 ZYX ZYX ITGB5 ITGB5 SKIL SKIL HIPK2 HIPK2 ITGB6 ITGB6 COL1A2 COL1A2 LTBP4 LTBP4 SMAD6 SMAD6 TGFBR2 TGFBR2 TGFB2 TGFB2 SMAD7 SMAD7 GCNT2 GCNT2 COL3A1 COL3A1 SMAD2 SMAD2 SMAD5 SMAD5 FOS FOS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRROSNegative regulator of reactive oxygen species. (692 aa)
LRRC32Leucine rich repeat containing 32. (663 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2581 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
FMODFibromodulin. (376 aa)
MTMR4Myotubularin related protein 4. (1196 aa)
SKISKI proto-oncogene. (718 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1424 aa)
ENSPCOP00000030534Uncharacterized protein. (49 aa)
STAT3Signal transducer and activator of transcription. (796 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1816 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (575 aa)
SIRT1Sirtuin 1. (743 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
PTK2Protein tyrosine kinase 2. (1089 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FOXH1Forkhead box H1. (367 aa)
FNTAFarnesyltransferase, CAAX box, alpha. (309 aa)
FLCNFolliculin. (579 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
SMAD3Mothers against decapentaplegic homolog. (443 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
TGFBR3LTransforming growth factor beta receptor 3 like. (313 aa)
FUT8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (536 aa)
ENGEndoglin. (657 aa)
ONECUT2One cut domain family member. (433 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1035 aa)
PMLPromyelocytic leukemia. (887 aa)
GDF5Growth differentiation factor 5. (499 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1306 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (786 aa)
SMAD9SMAD family member 9. (353 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (421 aa)
SRCTyrosine-protein kinase. (543 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (768 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
MSTNMyostatin. (376 aa)
FSHBFollicle stimulating hormone subunit beta. (129 aa)
PXNPaxillin. (1073 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (189 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (476 aa)
FERMT2Fermitin family member 2. (693 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (484 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (798 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
LOC105824854Uncharacterized protein. (312 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (591 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
NODALNodal growth differentiation factor. (348 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (661 aa)
TGFBRAP1Transforming growth factor beta receptor associated protein 1. (859 aa)
DUSP22Dual specificity phosphatase 22. (191 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1067 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LOC105824853Uncharacterized protein. (401 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (221 aa)
GLG1Golgi glycoprotein 1. (1068 aa)
ZYXZyxin. (570 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (802 aa)
SKILSKI like proto-oncogene. (664 aa)
HIPK2Homeodomain interacting protein kinase 2. (1187 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (766 aa)
COL1A2Collagen type I alpha 2 chain. (1364 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1626 aa)
SMAD6Mothers against decapentaplegic homolog. (500 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SMAD7Mothers against decapentaplegic homolog. (490 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (329 aa)
COL3A1Collagen type III alpha 1 chain. (1371 aa)
SMAD2Mothers against decapentaplegic homolog. (462 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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