STRINGSTRING
NUMBL NUMBL CDH5 CDH5 MED12L MED12L GRIP1 GRIP1 SETD1A SETD1A BTRC BTRC CXADR CXADR DVL3 DVL3 PRKN PRKN AMER1 AMER1 ENSPCOP00000016328 ENSPCOP00000016328 EP300 EP300 SPECC1L SPECC1L CTNND1 CTNND1 CDH26 CDH26 SMAD3 SMAD3 CTNNA3 CTNNA3 MED12 MED12 FOXO4 FOXO4 CTNNB1 CTNNB1 RORA RORA GSK3B GSK3B APC2 APC2 ESR1 ESR1 KDM6B KDM6B ASH2L ASH2L TBL1XR1 TBL1XR1 KANK3 KANK3 DVL1 DVL1 PTPRU PTPRU GJA1 GJA1 RUVBL2 RUVBL2 ENSPCOP00000028788 ENSPCOP00000028788 APC APC SOX9 SOX9 ENSPCOP00000029379 ENSPCOP00000029379 CTNNBIP1 CTNNBIP1 PTPRT PTPRT NUMB NUMB HDAC6 HDAC6 TCF7L1 TCF7L1 AXIN1 AXIN1 TAX1BP3 TAX1BP3 CTNNA1 CTNNA1 CALCOCO1 CALCOCO1 SALL1 SALL1 TCF7 TCF7 DACT1 DACT1 AR AR TCF4 TCF4 AJAP1 AJAP1 ENSPCOP00000014590 ENSPCOP00000014590 PSEN1 PSEN1 CARM1 CARM1 BCL9L BCL9L PTPRJ PTPRJ TCF7L2 TCF7L2 FOXO1 FOXO1 PIN1 PIN1 TJP1 TJP1 DACT2 DACT2 CD2AP CD2AP TRPC4 TRPC4 SKP1 SKP1 BCL9 BCL9 KANK1 KANK1 ENSPCOP00000009439 ENSPCOP00000009439 CTNND2 CTNND2 KLF4 KLF4 SUFU SUFU SOX17 SOX17 CDH1 CDH1 AXIN2 AXIN2 CHD8 CHD8 CDH2 CDH2 VCL VCL LZIC LZIC LEF1 LEF1 KANK2 KANK2 SLC9A3R2 SLC9A3R2 SMAD7 SMAD7 CDH24 CDH24 AMER2 AMER2 GLI3 GLI3 DLG5 DLG5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NUMBLNUMB like endocytic adaptor protein. (592 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (786 aa)
MED12LMediator complex subunit 12L. (2141 aa)
GRIP1Glutamate receptor interacting protein 1. (1104 aa)
SETD1ASET domain containing 1A, histone lysine methyltransferase. (1706 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (609 aa)
CXADRUncharacterized protein. (352 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (460 aa)
AMER1APC membrane recruitment protein 1. (796 aa)
ENSPCOP00000016328Uncharacterized protein. (111 aa)
EP300E1A binding protein p300. (2424 aa)
SPECC1LCalponin-homology (CH) domain-containing protein. (1132 aa)
CTNND1Catenin delta 1. (984 aa)
CDH26Cadherin 26. (783 aa)
SMAD3Mothers against decapentaplegic homolog. (443 aa)
CTNNA3Catenin alpha 3. (783 aa)
MED12Mediator complex subunit 12. (2187 aa)
FOXO4Forkhead box O4. (506 aa)
CTNNB1Catenin beta 1. (781 aa)
RORARAR related orphan receptor A. (532 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (390 aa)
APC2APC regulator of WNT signaling pathway 2. (2300 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (599 aa)
KDM6BLysine demethylase 6B. (1653 aa)
ASH2LASH2 like, histone lysine methyltransferase complex subunit. (639 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (514 aa)
KANK3KN motif and ankyrin repeat domains 3. (806 aa)
DVL1Dishevelled segment polarity protein 1. (722 aa)
PTPRUProtein tyrosine phosphatase receptor type U. (1446 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (397 aa)
ENSPCOP00000028788Uncharacterized protein. (171 aa)
APCAPC regulator of WNT signaling pathway. (2844 aa)
SOX9SRY-box transcription factor 9. (505 aa)
ENSPCOP00000029379Uncharacterized protein. (162 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
PTPRTProtein tyrosine phosphatase receptor type T. (1379 aa)
NUMBNUMB endocytic adaptor protein. (628 aa)
HDAC6Histone deacetylase 6. (1203 aa)
TCF7L1Transcription factor 7 like 1. (590 aa)
AXIN1Axin 1. (865 aa)
TAX1BP3Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (124 aa)
CTNNA1Catenin alpha 1. (906 aa)
CALCOCO1Calcium binding and coiled-coil domain 1. (691 aa)
SALL1Spalt like transcription factor 1. (1315 aa)
TCF7Transcription factor 7. (303 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (798 aa)
ARAndrogen receptor. (886 aa)
TCF4Transcription factor 4. (677 aa)
AJAP1Adherens junctions associated protein 1. (408 aa)
ENSPCOP00000014590Uncharacterized protein. (118 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (552 aa)
BCL9LBCL9 like. (1497 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1223 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
FOXO1Forkhead box O1. (656 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1768 aa)
DACT2Dishevelled binding antagonist of beta catenin 2. (701 aa)
CD2APCD2 associated protein. (534 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (138 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
KANK1KN motif and ankyrin repeat domains 1. (1350 aa)
ENSPCOP00000009439ASD2 domain-containing protein. (439 aa)
CTNND2Catenin delta 2. (1181 aa)
KLF4Uncharacterized protein. (486 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
SOX17SRY-box transcription factor 17. (413 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (904 aa)
AXIN2Axin 2. (716 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2592 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
VCLVinculin. (1134 aa)
LZICLeucine zipper and CTNNBIP1 domain containing. (251 aa)
LEF1Lymphoid enhancer binding factor 1. (432 aa)
KANK2KN motif and ankyrin repeat domains 2. (851 aa)
SLC9A3R2Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (337 aa)
SMAD7Mothers against decapentaplegic homolog. (490 aa)
CDH24Cadherin 24; Cadherins are calcium-dependent cell adhesion proteins. (822 aa)
AMER2APC membrane recruitment protein 2. (550 aa)
GLI3GLI family zinc finger 3. (1580 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1919 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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