STRINGSTRING
FNIP2 FNIP2 USP28 USP28 E2F1 E2F1 BCL3 BCL3 PIK3R1 PIK3R1 RAD9A RAD9A BAG6 BAG6 SHISA5 SHISA5 DDIT4 DDIT4 EP300 EP300 BAX BAX PML PML BCL2L1 BCL2L1 BCL2 BCL2 DYRK2 DYRK2 HTRA2 HTRA2 ENSPCOP00000023392 ENSPCOP00000023392 HIC1 HIC1 BCL2L11 BCL2L11 MCL1 MCL1 ELL3 ELL3 TOPORS TOPORS CHEK2 CHEK2 POLB POLB TNFRSF1A TNFRSF1A IKBKE IKBKE SIRT1 SIRT1 HIPK1 HIPK1 CASP9 CASP9 BAD BAD TP63 TP63 PYCARD PYCARD TP53 TP53 AEN AEN ATM ATM BAK1 BAK1 CASP2 CASP2 BBC3 BBC3 TNF TNF TNFRSF1B TNFRSF1B PPP2R5C PPP2R5C ENSPCOP00000000775 ENSPCOP00000000775 USP47 USP47 SFN SFN BCL2A1 BCL2A1 MAEL MAEL CIDEB CIDEB HIPK2 HIPK2 SKIL SKIL PHLDA3 PHLDA3 MLH1 MLH1 BOK BOK MSH2 MSH2 PRKDC PRKDC ERCC6 ERCC6 MSH6 MSH6 BRCA2 BRCA2 BCL2L10 BCL2L10 SNW1 SNW1 TMEM109 TMEM109 ENSPCOP00000009093 ENSPCOP00000009093 NFATC4 NFATC4 CDIP1 CDIP1 ENSPCOP00000009641 ENSPCOP00000009641 EPHA2 EPHA2 ATAD5 ATAD5 ENSPCOP00000012342 ENSPCOP00000012342 TP73 TP73
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FNIP2Folliculin interacting protein 2. (1114 aa)
USP28Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1061 aa)
E2F1E2F transcription factor 1. (436 aa)
BCL3BCL3 transcription coactivator. (454 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (393 aa)
BAG6BCL2 associated athanogene 6. (1124 aa)
SHISA5Shisa family member 5. (239 aa)
DDIT4DNA damage inducible transcript 4. (230 aa)
EP300E1A binding protein p300. (2424 aa)
BAXBCL2 associated X, apoptosis regulator. (199 aa)
PMLPromyelocytic leukemia. (887 aa)
BCL2L1BCL2 like 1. (233 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
ENSPCOP00000023392Uncharacterized protein. (157 aa)
HIC1HIC ZBTB transcriptional repressor 1. (732 aa)
BCL2L11BCL2 like 11. (200 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
ELL3Elongation factor for RNA polymerase II 3. (396 aa)
TOPORSTOP1 binding arginine/serine rich protein. (1040 aa)
CHEK2Checkpoint kinase 2. (571 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (333 aa)
TNFRSF1ATNF receptor superfamily member 1A. (447 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
SIRT1Sirtuin 1. (743 aa)
HIPK1Homeodomain interacting protein kinase 1. (1131 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (406 aa)
BADBCL2 associated agonist of cell death. (168 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
AENApoptosis enhancing nuclease. (325 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2635 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
BBC3BCL2 binding component 3. (260 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
TNFRSF1BTNF receptor superfamily member 1B. (449 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (542 aa)
ENSPCOP00000000775LIM zinc-binding domain-containing protein. (77 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
BCL2A1BCL2 related protein A1. (173 aa)
MAELMaelstrom spermatogenic transposon silencer. (434 aa)
CIDEBCell death inducing DFFA like effector b. (219 aa)
HIPK2Homeodomain interacting protein kinase 2. (1187 aa)
SKILSKI like proto-oncogene. (664 aa)
PHLDA3Pleckstrin homology like domain family A member 3. (125 aa)
MLH1MutL homolog 1. (757 aa)
BOKBCL2 family apoptosis regulator BOK. (213 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (868 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1488 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1229 aa)
BRCA2BRCA2 DNA repair associated. (3419 aa)
BCL2L10Uncharacterized protein. (192 aa)
SNW1SNW domain containing 1. (571 aa)
TMEM109Transmembrane protein 109. (243 aa)
ENSPCOP00000009093Uncharacterized protein. (88 aa)
NFATC4Nuclear factor of activated T cells 4. (953 aa)
CDIP1Cell death inducing p53 target 1. (208 aa)
ENSPCOP00000009641Uncharacterized protein. (136 aa)
EPHA2EPH receptor A2. (976 aa)
ATAD5ATPase family AAA domain containing 5. (1646 aa)
ENSPCOP00000012342RING-type domain-containing protein. (80 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (588 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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