STRINGSTRING
FYN FYN HTT HTT NRXN2 NRXN2 SLC2A1 SLC2A1 F11R F11R LOC105822640 LOC105822640 MEIS2 MEIS2 TGFBR2 TGFBR2 FAS FAS LTBR LTBR SLC1A3 SLC1A3 IGFBP2 IGFBP2 KCNK2 KCNK2 PKD2L1 PKD2L1 ENSPCOP00000000292 ENSPCOP00000000292 CHRNA10 CHRNA10 CHRNA9 CHRNA9 FOS FOS RELA RELA SLC9A1 SLC9A1 ENSPCOP00000031725 ENSPCOP00000031725 MAP2K4 MAP2K4 ENSPCOP00000031233 ENSPCOP00000031233 RPS6KB1 RPS6KB1 NPPA NPPA TRPV4 TRPV4 BAD BAD MYD88 MYD88 TMEM120A TMEM120A P2RX7 P2RX7 FOSL1 FOSL1 CSRP3 CSRP3 SOX9 SOX9 LOC105816957 LOC105816957 KIAA0319 KIAA0319 USP53 USP53 BAG3 BAG3 PPL PPL BMP6 BMP6 MAPK8 MAPK8 PTK2B PTK2B GATA4 GATA4 P2RY1 P2RY1 TNFRSF1A TNFRSF1A ENSPCOP00000027736 ENSPCOP00000027736 TRPA1 TRPA1 KRT5 KRT5 PDZD7 PDZD7 ENSPCOP00000027120 ENSPCOP00000027120 ITGA2 ITGA2 ENSPCOP00000026958 ENSPCOP00000026958 ASIC2 ASIC2 P2RX3 P2RX3 REST REST MAP3K2 MAP3K2 PDE2A PDE2A CD40 CD40 PTK2 PTK2 PKD1L1 PKD1L1 RETN RETN ENSPCOP00000024844 ENSPCOP00000024844 CRADD CRADD THBS1 THBS1 SCX SCX ENSPCOP00000024480 ENSPCOP00000024480 MAP3K14 MAP3K14 ANKRD1 ANKRD1 XPC XPC CYBA CYBA ENSPCOP00000024018 ENSPCOP00000024018 SUN1 SUN1 KIT KIT CASP8 CASP8 ASIC3 ASIC3 DAG1 DAG1 TGFB1 TGFB1 CTNNB1 CTNNB1 SERPINE2 SERPINE2 PTCH1 PTCH1 PLEC PLEC GADD45A GADD45A GSN GSN PIEZO2 PIEZO2 PIEZO1 PIEZO1 MAG MAG MPO MPO ETV1 ETV1 PIK3CA PIK3CA TMEM150C TMEM150C TLR8 TLR8 PKD2 PKD2 BNIP3 BNIP3 CASP1 CASP1 NFKBIA NFKBIA ENSPCOP00000014148 ENSPCOP00000014148 PKDREJ PKDREJ PHF24 PHF24 NRXN1 NRXN1 ANKRD23 ANKRD23 TNFSF14 TNFSF14 SLC26A5 SLC26A5 SLC8A1 SLC8A1 TACR1 TACR1 LRP11 LRP11 JUP JUP MDK MDK CNN2 CNN2 IL1B IL1B CHI3L1 CHI3L1 PKD2L2 PKD2L2 RYR2 RYR2 NTRK1 NTRK1 ENSPCOP00000010394 ENSPCOP00000010394 ADGRV1 ADGRV1 MAP3K1 MAP3K1 LOC105819868 LOC105819868 TLR3 TLR3 IRF1 IRF1 LRRIQ1 LRRIQ1 PTGS2 PTGS2 AQP1 AQP1 ENSPCOP00000008878 ENSPCOP00000008878 PKD1L3 PKD1L3 MAPK3 MAPK3 NFKB1 NFKB1 STAT1 STAT1 MMP2 MMP2 STRA6 STRA6 TMC1 TMC1 SHANK3 SHANK3 CXCL12 CXCL12 JUND JUND WNT11 WNT11 TBC1D31 TBC1D31 KCNK4 KCNK4 MBD2 MBD2 CAV3 CAV3 PTPRQ PTPRQ MTPN MTPN PKD1 PKD1 FOSB FOSB IHH IHH MAPK10 MAPK10 CASP8AP2 CASP8AP2 BACE1 BACE1 HPN HPN COL11A1 COL11A1 IGF1R IGF1R CITED2 CITED2 FADD FADD ENSPCOP00000021800 ENSPCOP00000021800 BTG2 BTG2 PJVK PJVK PTGER4 PTGER4 SCN1A SCN1A SOST SOST ENG ENG CLCN6 CLCN6 COL1A1 COL1A1 ABHD12 ABHD12 TNFRSF8 TNFRSF8 GDF5 GDF5 PTN PTN DDR2 DDR2 WHRN WHRN TMC2 TMC2 SRC SRC TCAP TCAP SCEL SCEL BDKRB1 BDKRB1 MAP1B MAP1B STRC STRC ANGPT2 ANGPT2 MKKS MKKS MAPK14 MAPK14 KCNQ1 KCNQ1 BAK1 BAK1 GCLC GCLC LHFPL5 LHFPL5 CHEK1 CHEK1 CASP2 CASP2 HABP4 HABP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FYNTyrosine-protein kinase. (537 aa)
HTTHuntingtin. (3122 aa)
NRXN2Neurexin 2. (1712 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (495 aa)
F11RF11 receptor. (296 aa)
LOC105822640Integrin beta; Belongs to the integrin beta chain family. (454 aa)
MEIS2Meis homeobox 2. (477 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
FASFas cell surface death receptor. (309 aa)
LTBRLymphotoxin beta receptor. (435 aa)
SLC1A3Amino acid transporter. (542 aa)
IGFBP2Insulin like growth factor binding protein 2. (321 aa)
KCNK2Potassium two pore domain channel subfamily K member 2. (371 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (804 aa)
ENSPCOP00000000292Uncharacterized protein. (404 aa)
CHRNA10Cholinergic receptor nicotinic alpha 10 subunit. (450 aa)
CHRNA9Cholinergic receptor nicotinic alpha 9 subunit. (479 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
ENSPCOP00000031725Protein kinase domain-containing protein. (272 aa)
MAP2K4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
ENSPCOP00000031233Uncharacterized protein. (318 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
NPPANatriuretic peptide A. (153 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
BADBCL2 associated agonist of cell death. (168 aa)
MYD88MYD88 innate immune signal transduction adaptor. (353 aa)
TMEM120ATransmembrane protein 120A. (343 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (272 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
SOX9SRY-box transcription factor 9. (505 aa)
LOC105816957Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (424 aa)
KIAA0319KIAA0319. (1073 aa)
USP53Ubiquitin specific peptidase 53. (1092 aa)
BAG3BCL2 associated athanogene 3. (577 aa)
PPLPeriplakin. (1756 aa)
BMP6Bone morphogenetic protein 6. (509 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (967 aa)
GATA4GATA binding protein 4. (445 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
TNFRSF1ATNF receptor superfamily member 1A. (447 aa)
ENSPCOP00000027736G_PROTEIN_RECEP_F2_4 domain-containing protein. (334 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1091 aa)
KRT5Keratin 5; Belongs to the intermediate filament family. (588 aa)
PDZD7PDZ domain containing 7. (1025 aa)
ENSPCOP00000027120Uncharacterized protein. (1243 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1129 aa)
ENSPCOP00000026958Uncharacterized protein. (5601 aa)
ASIC2Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (563 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
RESTUncharacterized protein. (1018 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (619 aa)
PDE2APhosphodiesterase. (940 aa)
CD40CD40 molecule. (281 aa)
PTK2Protein tyrosine kinase 2. (1089 aa)
PKD1L1Polycystin 1 like 1, transient receptor potential channel interacting. (2710 aa)
RETNResistin. (85 aa)
ENSPCOP00000024844Uncharacterized protein. (639 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
THBS1Thrombospondin 1. (1185 aa)
SCXScleraxis bHLH transcription factor. (208 aa)
ENSPCOP00000024480Uncharacterized protein. (103 aa)
MAP3K14Uncharacterized protein. (151 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (867 aa)
CYBACytochrome b-245 alpha chain. (129 aa)
ENSPCOP00000024018Uncharacterized protein. (637 aa)
SUN1Sad1 and UNC84 domain containing 1. (682 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
ASIC3Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (537 aa)
DAG1Dystroglycan 1. (895 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CTNNB1Catenin beta 1. (781 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
PTCH1Patched 1. (1449 aa)
PLECPlectin. (4689 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
GSNGelsolin. (778 aa)
PIEZO2Piezo-type mechanosensitive ion channel component. (2719 aa)
PIEZO1Piezo-type mechanosensitive ion channel component. (2465 aa)
MAGMyelin associated glycoprotein. (626 aa)
MPOMyeloperoxidase. (742 aa)
ETV1ETS variant 1. (471 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
TMEM150CTransmembrane protein 150C. (201 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1039 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (963 aa)
BNIP3Uncharacterized protein. (235 aa)
CASP1Uncharacterized protein; Belongs to the peptidase C14A family. (254 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
ENSPCOP00000014148Uncharacterized protein. (733 aa)
PKDREJPolycystin family receptor for egg jelly. (2266 aa)
PHF24PHD finger protein 24. (400 aa)
NRXN1Neurexin 1. (1449 aa)
ANKRD23Ankyrin repeat domain 23. (306 aa)
TNFSF14TNF superfamily member 14. (241 aa)
SLC26A5Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (650 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (974 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
LRP11LDL receptor related protein 11. (500 aa)
JUPJunction plakoglobin. (745 aa)
MDKMidkine. (143 aa)
CNN2Calponin 2. (317 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (385 aa)
PKD2L2Polycystin 2 like 2, transient receptor potential cation channel. (489 aa)
RYR2Ryanodine receptor 2. (4825 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
ENSPCOP00000010394Uncharacterized protein. (417 aa)
ADGRV1GPS domain-containing protein. (5403 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1508 aa)
LOC105819868Protein kinase domain-containing protein. (302 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
IRF1Interferon regulatory factor. (324 aa)
LRRIQ1Leucine rich repeats and IQ motif containing 1. (1390 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
ENSPCOP00000008878Uncharacterized protein. (329 aa)
PKD1L3Polycystin 1 like 3, transient receptor potential channel interacting. (1655 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
NFKB1Nuclear factor kappa B subunit 1. (961 aa)
STAT1Signal transducer and activator of transcription. (794 aa)
MMP2Matrix metallopeptidase 2. (552 aa)
STRA6Stimulated by retinoic acid 6. (687 aa)
TMC1Transmembrane channel-like protein. (774 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1726 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (159 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (348 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
TBC1D31TBC1 domain family member 31. (1062 aa)
KCNK4Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (393 aa)
MBD2Methyl-CpG binding domain protein 2. (410 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
PTPRQProtein tyrosine phosphatase receptor type Q. (1969 aa)
MTPNMyotrophin. (118 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4265 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
CASP8AP2Caspase 8 associated protein 2. (1963 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)
HPNPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (417 aa)
COL11A1Collagen type XI alpha 1 chain. (1670 aa)
IGF1RTyrosine-protein kinase receptor. (1350 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (205 aa)
ENSPCOP00000021800Uncharacterized protein. (175 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
PJVKPejvakin. (352 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1741 aa)
SOSTSclerostin. (213 aa)
ENGEndoglin. (657 aa)
CLCN6Chloride voltage-gated channel 6; Belongs to the chloride channel (TC 2.A.49) family. (929 aa)
COL1A1Collagen type I alpha 1 chain. (1461 aa)
ABHD12Abhydrolase domain containing 12. (397 aa)
TNFRSF8Uncharacterized protein. (238 aa)
GDF5Growth differentiation factor 5. (499 aa)
PTNPleiotrophin. (177 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
WHRNWhirlin. (905 aa)
TMC2Transmembrane channel-like protein. (894 aa)
SRCTyrosine-protein kinase. (543 aa)
TCAPTitin-cap. (167 aa)
SCELSciellin. (630 aa)
BDKRB1Bradykinin receptor B1. (274 aa)
MAP1BMicrotubule associated protein 1B. (2462 aa)
STRCStereocilin. (1739 aa)
ANGPT2Angiopoietin 2. (496 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
MAPK14Mitogen-activated protein kinase 14. (340 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (545 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
LHFPL5LHFPL tetraspan subfamily member 5. (236 aa)
CHEK1Checkpoint kinase 1. (454 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
HABP4Hyaluronan binding protein 4. (417 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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