(21 nodes) Response to iron ion network (Propithecus coquereli)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	ATP7A	ATPase copper transporting alpha. (1502 aa)
	HAMP	Hepcidin antimicrobial peptide. (84 aa)
	LOC105815021	Uncharacterized protein. (567 aa)
	ACO1	Aconitase 1; Belongs to the aconitase/IPM isomerase family. (790 aa)
	TFAP2A	Transcription factor AP-2 alpha. (439 aa)
	HFE	Homeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
	SLC11A2	Uncharacterized protein. (590 aa)
	ABAT	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
	FXN	Frataxin. (211 aa)
	CPOX	Coproporphyrinogen oxidase. (443 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (826 aa)
	HMOX1	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
	BCL2	BCL2 apoptosis regulator. (234 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (120 aa)
	TFR2	Transferrin receptor 2. (806 aa)
	BMP6	Bone morphogenetic protein 6. (509 aa)
	MAP1LC3A	Microtubule associated protein 1 light chain 3 alpha. (121 aa)
	G6PD	Glucose-6-phosphate dehydrogenase. (558 aa)
	TF	Transferrin; Belongs to the transferrin family. (697 aa)
	SLC40A1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (573 aa)
	FN1	Fibronectin 1. (2290 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACO1	FXN	ENSPCOP00000018600	ENSPCOP00000007761	Aconitase 1; Belongs to the aconitase/IPM isomerase family.	Frataxin.	0.656
ACO1	LOC105815021	ENSPCOP00000018600	ENSPCOP00000019091	Aconitase 1; Belongs to the aconitase/IPM isomerase family.	Uncharacterized protein.	0.420
ACO1	SLC11A2	ENSPCOP00000018600	ENSPCOP00000013109	Aconitase 1; Belongs to the aconitase/IPM isomerase family.	Uncharacterized protein.	0.420
ACO1	SLC40A1	ENSPCOP00000018600	ENSPCOP00000025552	Aconitase 1; Belongs to the aconitase/IPM isomerase family.	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.	0.449
ACO1	TFR2	ENSPCOP00000018600	ENSPCOP00000024112	Aconitase 1; Belongs to the aconitase/IPM isomerase family.	Transferrin receptor 2.	0.472
ATP7A	LOC105815021	ENSPCOP00000022605	ENSPCOP00000019091	ATPase copper transporting alpha.	Uncharacterized protein.	0.440
ATP7A	SLC11A2	ENSPCOP00000022605	ENSPCOP00000013109	ATPase copper transporting alpha.	Uncharacterized protein.	0.440
B2M	HFE	ENSPCOP00000022681	ENSPCOP00000014724	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Homeostatic iron regulator; Belongs to the MHC class I family.	0.976
B2M	TF	ENSPCOP00000022681	ENSPCOP00000026804	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Transferrin; Belongs to the transferrin family.	0.402
B2M	TFR2	ENSPCOP00000022681	ENSPCOP00000024112	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Transferrin receptor 2.	0.735
BCL2	HIF1A	ENSPCOP00000020794	ENSPCOP00000004706	BCL2 apoptosis regulator.	Hypoxia inducible factor 1 subunit alpha.	0.681
BCL2	HMOX1	ENSPCOP00000020794	ENSPCOP00000004255	BCL2 apoptosis regulator.	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.	0.529
BCL2	MAP1LC3A	ENSPCOP00000020794	ENSPCOP00000028878	BCL2 apoptosis regulator.	Microtubule associated protein 1 light chain 3 alpha.	0.414
BMP6	HAMP	ENSPCOP00000028377	ENSPCOP00000019150	Bone morphogenetic protein 6.	Hepcidin antimicrobial peptide.	0.544
BMP6	HFE	ENSPCOP00000028377	ENSPCOP00000014724	Bone morphogenetic protein 6.	Homeostatic iron regulator; Belongs to the MHC class I family.	0.548
BMP6	TFR2	ENSPCOP00000028377	ENSPCOP00000024112	Bone morphogenetic protein 6.	Transferrin receptor 2.	0.531
CPOX	HMOX1	ENSPCOP00000004875	ENSPCOP00000004255	Coproporphyrinogen oxidase.	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.	0.505
FXN	ACO1	ENSPCOP00000007761	ENSPCOP00000018600	Frataxin.	Aconitase 1; Belongs to the aconitase/IPM isomerase family.	0.656
FXN	HMOX1	ENSPCOP00000007761	ENSPCOP00000004255	Frataxin.	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.	0.886
HAMP	BMP6	ENSPCOP00000019150	ENSPCOP00000028377	Hepcidin antimicrobial peptide.	Bone morphogenetic protein 6.	0.544