STRINGSTRING
BAK1 BAK1 LOC105809598 LOC105809598 MYC MYC TIGAR TIGAR ELK1 ELK1 EGR1 EGR1 FANCD2 FANCD2 LOC105809597 LOC105809597 ERCC6 ERCC6 DCUN1D3 DCUN1D3 RAD51 RAD51 BRCA2 BRCA2 TMEM109 TMEM109 GATA3 GATA3 LOC105817821 LOC105817821 ZMPSTE24 ZMPSTE24 PARP1 PARP1 YAP1 YAP1 ENSPCOP00000011661 ENSPCOP00000011661 CBL CBL HSF1 HSF1 ATR ATR ATM ATM ENSPCOP00000004338 ENSPCOP00000004338 XRCC4 XRCC4 XRCC5 XRCC5 APOBEC1 APOBEC1 PRKDC PRKDC ENSPCOP00000019705 ENSPCOP00000019705 PML PML KDM1A KDM1A BCL2L1 BCL2L1 BCL2 BCL2 TLK2 TLK2 LOC105825161 LOC105825161 BAX BAX MEN1 MEN1 PRKAA1 PRKAA1 CYBA CYBA ENSPCOP00000025005 ENSPCOP00000025005 CHEK2 CHEK2 POLB POLB MAP3K20 MAP3K20 GTF2H5 GTF2H5 XRCC6 XRCC6 TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BAK1BCL2 antagonist/killer 1. (211 aa)
LOC105809598Uncharacterized protein. (71 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
ELK1ETS transcription factor ELK1. (430 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
FANCD2FA complementation group D2. (1424 aa)
LOC105809597General transcription factor IIH subunit 5 pseudogene. (71 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1488 aa)
DCUN1D3DCN1-like protein. (304 aa)
RAD51RAD51 recombinase; Belongs to the RecA family. (340 aa)
BRCA2BRCA2 DNA repair associated. (3419 aa)
TMEM109Transmembrane protein 109. (243 aa)
GATA3Uncharacterized protein. (444 aa)
LOC105817821X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (689 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
YAP1Uncharacterized protein. (504 aa)
ENSPCOP00000011661DCN1-like protein. (292 aa)
CBLCbl proto-oncogene. (891 aa)
HSF1Heat shock transcription factor 1. (531 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2635 aa)
ENSPCOP00000004338Uncharacterized protein. (69 aa)
XRCC4X-ray repair cross complementing 4. (297 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (677 aa)
APOBEC1Apolipoprotein B mRNA editing enzyme catalytic subunit 1. (226 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4130 aa)
ENSPCOP00000019705Uncharacterized protein. (583 aa)
PMLPromyelocytic leukemia. (887 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (875 aa)
BCL2L1BCL2 like 1. (233 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
TLK2Tousled like kinase 2. (724 aa)
LOC105825161RECA_2 domain-containing protein. (281 aa)
BAXBCL2 associated X, apoptosis regulator. (199 aa)
MEN1Menin 1. (616 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
CYBACytochrome b-245 alpha chain. (129 aa)
ENSPCOP00000025005Uncharacterized protein. (351 aa)
CHEK2Checkpoint kinase 2. (571 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (333 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
GTF2H5Uncharacterized protein. (71 aa)
XRCC6X-ray repair cross complementing 6. (496 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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