STRINGSTRING
IFNG IFNG BCL2 BCL2 DNM1L DNM1L DAP DAP SNX18 SNX18 ENSPCOP00000021139 ENSPCOP00000021139 TBC1D14 TBC1D14 LOC105823974 LOC105823974 TLK2 TLK2 TRIML2 TRIML2 ENSPCOP00000021800 ENSPCOP00000021800 TMEM39A TMEM39A MAPK10 MAPK10 SLC25A6 SLC25A6 SNRNP70 SNRNP70 TAB2 TAB2 ENSPCOP00000022199 ENSPCOP00000022199 SNX4 SNX4 DAPK3 DAPK3 SESN2 SESN2 RMC1 RMC1 PIP4K2A PIP4K2A SREBF2 SREBF2 ATP13A2 ATP13A2 CTSA CTSA GSK3B GSK3B ERN1 ERN1 RAB8A RAB8A TP53INP1 TP53INP1 HTRA2 HTRA2 FLCN FLCN DAPL1 DAPL1 WDR24 WDR24 PRKAA1 PRKAA1 PIK3R4 PIK3R4 SREBF1 SREBF1 ATP6V1G1 ATP6V1G1 RUBCN RUBCN FBXL2 FBXL2 BCL2L11 BCL2L11 FBXW9 FBXW9 RIPK2 RIPK2 PINK1 PINK1 LRRK2 LRRK2 CSNK2A2 CSNK2A2 CRYBA1 CRYBA1 ITPR1 ITPR1 TPCN1 TPCN1 WIPI1 WIPI1 MCL1 MCL1 CISD1 CISD1 TICAM1 TICAM1 CDK5 CDK5 SLC7A5 SLC7A5 SCFD1 SCFD1 ATP6V0A2 ATP6V0A2 BNIP3L BNIP3L KEAP1 KEAP1 IKBKG IKBKG PRKAA2 PRKAA2 PIK3C3 PIK3C3 GATA4 GATA4 SIRT1 SIRT1 LOC105826437 LOC105826437 FEZ1 FEZ1 EIF4G1 EIF4G1 MAPK8 MAPK8 ENSPCOP00000028434 ENSPCOP00000028434 KAT8 KAT8 PIP4K2B PIP4K2B AKT1 AKT1 TRIM65 TRIM65 BAG3 BAG3 RRAGD RRAGD NOD2 NOD2 NLRP6 NLRP6 PARK7 PARK7 LOC105816616 LOC105816616 HDAC6 HDAC6 CPTP CPTP SLC25A4 SLC25A4 ATG2A ATG2A HTR2B HTR2B STAT3 STAT3 BAD BAD HSPB1 HSPB1 CCNY CCNY AMBRA1 AMBRA1 MTMR4 MTMR4 EXOC7 EXOC7 NEDD4 NEDD4 PYCARD PYCARD FOXK2 FOXK2 FOXK1 FOXK1 NOD1 NOD1 ATG14 ATG14 HPSE HPSE TP53 TP53 ADRA1A ADRA1A GPSM1 GPSM1 KAT5 KAT5 VPS13C VPS13C ATP6V0C ATP6V0C USP13 USP13 EXOC8 EXOC8 TRIB3 TRIB3 MTMR9 MTMR9 SH3BP4 SH3BP4 KIAA1324 KIAA1324 ULK1 ULK1 TRIM8 TRIM8 NPRL2 NPRL2 CDK5R1 CDK5R1 TMEM59 TMEM59 RNF41 RNF41 RASIP1 RASIP1 MTOR MTOR UBQLN2 UBQLN2 DCAF12L2 DCAF12L2 TSC1 TSC1 HERC1 HERC1 TFEB TFEB TRIM32 TRIM32 LOC105806099 LOC105806099 PRKD1 PRKD1 HTT HTT RRAGC RRAGC CAMKK2 CAMKK2 LOC105808350 LOC105808350 PHF23 PHF23 MTCL1 MTCL1 IL10RA IL10RA RRAGB RRAGB TIGAR TIGAR SCOC SCOC MTMR3 MTMR3 DRAM1 DRAM1 PARL PARL MT3 MT3 CTTN CTTN USP36 USP36 STK11 STK11 RNF152 RNF152 ATP6V0A1 ATP6V0A1 LOC105808544 LOC105808544 XBP1 XBP1 EHMT2 EHMT2 HMOX1 HMOX1 LOC105825287 LOC105825287 BOK BOK STING1 STING1 ERCC4 ERCC4 TRIML1 TRIML1 ENSPCOP00000004671 ENSPCOP00000004671 TMEM39B TMEM39B HIF1A HIF1A RAB39B RAB39B CLEC16A CLEC16A KDR KDR RB1CC1 RB1CC1 RAB3GAP1 RAB3GAP1 LZTS1 LZTS1 FEZ2 FEZ2 NRBP2 NRBP2 RRAGA RRAGA WAC WAC LOC105822429 LOC105822429 ATP6V1H ATP6V1H USP10 USP10 MID2 MID2 EPM2A EPM2A LEP LEP SEC22B SEC22B TRIM6 TRIM6 HAX1 HAX1 ENSPCOP00000006829 ENSPCOP00000006829 MTDH MTDH FYCO1 FYCO1 ULK2 ULK2 ATP6V1B2 ATP6V1B2 PLK2 PLK2 DAPK2 DAPK2 ENSPCOP00000007742 ENSPCOP00000007742 ROCK1 ROCK1 MFSD8 MFSD8 TBC1D25 TBC1D25 IL10 IL10 MAPK3 MAPK3 KLHL22 KLHL22 ATG5 ATG5 PTPN22 PTPN22 DAPK1 DAPK1 TECPR1 TECPR1 ZC3H12A ZC3H12A ENSPCOP00000009106 ENSPCOP00000009106 UFL1 UFL1 ENSPCOP00000009180 ENSPCOP00000009180 RHEB RHEB ATG101 ATG101 RNF31 RNF31 ENSPCOP00000009641 ENSPCOP00000009641 DRAM2 DRAM2 RPTOR RPTOR QSOX1 QSOX1 ZMPSTE24 ZMPSTE24 DCAF12 DCAF12 USP30 USP30 CLN3 CLN3 ORMDL3 ORMDL3 DDIT3 DDIT3 RAB3GAP2 RAB3GAP2 SOGA1 SOGA1 LARP1 LARP1 GPR137B GPR137B LEPR LEPR LOC105821613 LOC105821613 ATG16L1 ATG16L1 VPS35 VPS35 SIRT2 SIRT2 ATP6V1C2 ATP6V1C2 UBQLN4 UBQLN4 VPS13D VPS13D TRIM14 TRIM14 FOXO1 FOXO1 MTMR8 MTMR8 DCN DCN TREM2 TREM2 TAB3 TAB3 CDK16 CDK16 SESN3 SESN3 PIP4K2C PIP4K2C TPCN2 TPCN2 BMF BMF ENSPCOP00000012870 ENSPCOP00000012870 TRIM27 TRIM27 ATP6V0B ATP6V0B GSK3A GSK3A LRSAM1 LRSAM1 ENSPCOP00000013298 ENSPCOP00000013298 VPS26A VPS26A HSPB8 HSPB8 CISD2 CISD2 SPTLC1 SPTLC1 ENSPCOP00000013979 ENSPCOP00000013979 MEFV MEFV WDR6 WDR6 SOGA3 SOGA3 TSPO TSPO ENSPCOP00000014679 ENSPCOP00000014679 ENSPCOP00000014900 ENSPCOP00000014900 BNIP3 BNIP3 CHMP4B CHMP4B ENSPCOP00000015479 ENSPCOP00000015479 PIK3CA PIK3CA NPRL3 NPRL3 ENSPCOP00000015642 ENSPCOP00000015642 KDM4A KDM4A MLST8 MLST8 GFAP GFAP OSBPL7 OSBPL7 WDR41 WDR41 ACER2 ACER2 TSC2 TSC2 PRKN PRKN PIK3CB PIK3CB ENSPCOP00000016492 ENSPCOP00000016492 SLC25A5 SLC25A5 TBK1 TBK1 DHRSX DHRSX SMCR8 SMCR8 SNX30 SNX30 GPR137 GPR137 ENSPCOP00000017250 ENSPCOP00000017250 CAPNS1 CAPNS1 ATM ATM KIAA0408 KIAA0408 IL4 IL4 UVRAG UVRAG PAFAH1B2 PAFAH1B2 ABL2 ABL2 SMG1 SMG1 HGF HGF PIK3R2 PIK3R2 TP53INP2 TP53INP2 POLDIP2 POLDIP2 NPC1 NPC1 SNX7 SNX7 SUPT5H SUPT5H FBXO7 FBXO7 ATG7 ATG7 EP300 EP300 VDAC1 VDAC1 FBXW7 FBXW7 CALCOCO2 CALCOCO2 WDR45 WDR45 LOC105821266 LOC105821266 BCL2L1 BCL2L1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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co-expression
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IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
BCL2BCL2 apoptosis regulator. (234 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
DAPUncharacterized protein. (102 aa)
SNX18Sorting nexin. (622 aa)
ENSPCOP00000021139Sec3-PIP2_bind domain-containing protein. (386 aa)
TBC1D14Rab-GAP TBC domain-containing protein. (305 aa)
LOC105823974WH2 domain-containing protein. (464 aa)
TLK2Tousled like kinase 2. (724 aa)
TRIML2Tripartite motif family like 2. (437 aa)
ENSPCOP00000021800Uncharacterized protein. (175 aa)
TMEM39ATransmembrane protein 39A. (488 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
SLC25A6Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
SNRNP70Small nuclear ribonucleoprotein U1 subunit 70. (435 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
ENSPCOP00000022199Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (282 aa)
SNX4Sorting nexin 4. (420 aa)
DAPK3Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
SESN2Sestrin 2. (480 aa)
RMC1Mic1 domain-containing protein. (521 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (406 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1133 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1174 aa)
CTSACarboxypeptidase; Belongs to the peptidase S10 family. (494 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (390 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (935 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (241 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
FLCNFolliculin. (579 aa)
DAPL1Death associated protein like 1. (107 aa)
WDR24WD repeat domain 24. (884 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1180 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
RUBCNRubicon autophagy regulator. (963 aa)
FBXL2F-box and leucine rich repeat protein 2. (423 aa)
BCL2L11BCL2 like 11. (200 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (539 aa)
PINK1PTEN induced kinase 1. (581 aa)
LRRK2Leucine rich repeat kinase 2. (2427 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (356 aa)
CRYBA1Crystallin beta A1; Belongs to the beta/gamma-crystallin family. (215 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2732 aa)
TPCN1Two pore segment channel 1. (818 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (446 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
CISD1CDGSH iron sulfur domain 1. (108 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (692 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
SLC7A5Solute carrier family 7 member 5. (489 aa)
SCFD1Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (942 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (829 aa)
BNIP3LBCL2 interacting protein 3 like. (219 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (490 aa)
PRKAA2Non-specific serine/threonine protein kinase. (553 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (734 aa)
GATA4GATA binding protein 4. (445 aa)
SIRT1Sirtuin 1. (743 aa)
LOC105826437E3 ubiquitin-protein ligase TRIM32. (653 aa)
FEZ1Uncharacterized protein. (104 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1605 aa)
MAPK8Mitogen-activated protein kinase 8. (346 aa)
ENSPCOP00000028434RUN domain-containing protein. (177 aa)
KAT8Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (459 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (416 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TRIM65Tripartite motif containing 65. (515 aa)
BAG3BCL2 associated athanogene 3. (577 aa)
RRAGDRas related GTP binding D. (399 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
NLRP6NLR family pyrin domain containing 6. (890 aa)
PARK7DJ-1_PfpI domain-containing protein. (155 aa)
LOC105816616Uncharacterized protein. (85 aa)
HDAC6Histone deacetylase 6. (1203 aa)
CPTPCeramide-1-phosphate transfer protein. (214 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
ATG2AAutophagy related 2A. (1931 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
STAT3Signal transducer and activator of transcription. (796 aa)
BADBCL2 associated agonist of cell death. (168 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (206 aa)
CCNYCyclin Y; Belongs to the cyclin family. (264 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1270 aa)
MTMR4Myotubularin related protein 4. (1196 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (706 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1320 aa)
PYCARDPYD and CARD domain containing. (195 aa)
FOXK2Forkhead box K2. (631 aa)
FOXK1Forkhead box K1. (731 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (949 aa)
ATG14Autophagy related 14. (464 aa)
HPSEHeparanase. (395 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
ADRA1AAdrenoceptor alpha 1A. (466 aa)
GPSM1G protein signaling modulator 1. (697 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
VPS13CVacuolar protein sorting 13 homolog C. (3076 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (154 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (863 aa)
EXOC8Exocyst complex component 8. (728 aa)
TRIB3Tribbles pseudokinase 3. (367 aa)
MTMR9Myotubularin related protein 9. (470 aa)
SH3BP4SH3 domain binding protein 4. (963 aa)
KIAA1324KIAA1324. (880 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1045 aa)
TRIM8Tripartite motif containing 8. (551 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (306 aa)
TMEM59Transmembrane protein 59. (324 aa)
RNF41Ring finger protein 41. (317 aa)
RASIP1Ras interacting protein 1. (961 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
UBQLN2Ubiquilin 2. (624 aa)
DCAF12L2DDB1 and CUL4 associated factor 12 like 2. (465 aa)
TSC1TSC complex subunit 1. (1164 aa)
HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. (4846 aa)
TFEBTranscription factor EB. (525 aa)
TRIM32Uncharacterized protein. (653 aa)
LOC105806099WH2 domain-containing protein. (466 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (860 aa)
HTTHuntingtin. (3122 aa)
RRAGCUncharacterized protein. (399 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (587 aa)
LOC105808350Uncharacterized protein. (768 aa)
PHF23PHD finger protein 23. (404 aa)
MTCL1Microtubule crosslinking factor 1. (1897 aa)
IL10RAInterleukin 10 receptor subunit alpha. (578 aa)
RRAGBRas related GTP binding B. (374 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
SCOCUncharacterized protein. (122 aa)
MTMR3Myotubularin related protein 3. (1201 aa)
DRAM1DNA damage regulated autophagy modulator 1. (238 aa)
PARLRhomboid domain-containing protein. (362 aa)
MT3Metallothionein 3; Belongs to the metallothionein superfamily. Type 1 family. (114 aa)
CTTNCortactin. (550 aa)
USP36Ubiquitin specific peptidase 36; Belongs to the peptidase C19 family. (1121 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
RNF152Ring finger protein 152. (203 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (756 aa)
LOC105808544Myotubularin phosphatase domain-containing protein. (538 aa)
XBP1BZIP domain-containing protein. (377 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1267 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
LOC105825287DJ-1_PfpI domain-containing protein. (189 aa)
BOKBCL2 family apoptosis regulator BOK. (213 aa)
STING1Transmembrane protein 173. (374 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (879 aa)
TRIML1Tripartite motif family like 1. (468 aa)
ENSPCOP00000004671Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (276 aa)
TMEM39BTransmembrane protein 39B. (492 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
RAB39BRAB39B, member RAS oncogene family. (213 aa)
CLEC16AC-type lectin domain containing 16A. (1053 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
RB1CC1RB1 inducible coiled-coil 1. (1590 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (916 aa)
LZTS1Leucine zipper tumor suppressor 1. (597 aa)
FEZ2Fasciculation and elongation protein zeta 2. (376 aa)
NRBP2Nuclear receptor binding protein 2. (499 aa)
RRAGARas related GTP binding A. (313 aa)
WACWW domain containing adaptor with coiled-coil. (632 aa)
LOC105822429Uncharacterized protein. (392 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (453 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (798 aa)
MID2Midline 2. (735 aa)
EPM2AEPM2A glucan phosphatase, laforin. (325 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
SEC22BSEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (215 aa)
TRIM6Tripartite motif containing 6. (510 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (278 aa)
ENSPCOP00000006829Uncharacterized protein. (252 aa)
MTDHMetadherin. (580 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1492 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1036 aa)
ATP6V1B2ATPase H+ transporting V1 subunit B2. (448 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa)
ENSPCOP00000007742Uncharacterized protein. (194 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1316 aa)
MFSD8Major facilitator superfamily domain containing 8. (519 aa)
TBC1D25TBC1 domain family member 25. (687 aa)
IL10Interleukin 10. (178 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
KLHL22Kelch like family member 22. (633 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (653 aa)
DAPK1Death associated protein kinase 1. (1430 aa)
TECPR1Tectonin beta-propeller repeat containing 1. (1157 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (598 aa)
ENSPCOP00000009106Uncharacterized protein. (351 aa)
UFL1UFM1 specific ligase 1. (553 aa)
ENSPCOP00000009180Uncharacterized protein. (265 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
ATG101Autophagy related 101. (218 aa)
RNF31Uncharacterized protein. (1072 aa)
ENSPCOP00000009641Uncharacterized protein. (136 aa)
DRAM2DNA damage regulated autophagy modulator 2. (266 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1281 aa)
QSOX1Sulfhydryl oxidase. (711 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
DCAF12DDB1 and CUL4 associated factor 12. (453 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (517 aa)
CLN3Battenin. (438 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2. (1123 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1412 aa)
LARP1La ribonucleoprotein domain family member 1. (905 aa)
GPR137BG protein-coupled receptor 137B. (396 aa)
LEPRLeptin receptor. (1055 aa)
LOC105821613Rab-GAP TBC domain-containing protein. (531 aa)
ATG16L1Autophagy related 16 like 1. (609 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
SIRT2Sirtuin 2. (469 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (414 aa)
UBQLN4Ubiquilin 4. (601 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4364 aa)
TRIM14Tripartite motif containing 14. (447 aa)
FOXO1Forkhead box O1. (656 aa)
MTMR8Myotubularin related protein 8. (700 aa)
DCNDecorin; May affect the rate of fibrils formation. (290 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (224 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (710 aa)
CDK16Cyclin dependent kinase 16. (567 aa)
SESN3Sestrin 3. (495 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (421 aa)
TPCN2Two pore segment channel 2. (752 aa)
BMFBcl2 modifying factor. (184 aa)
ENSPCOP00000012870PX domain-containing protein. (443 aa)
TRIM27Tripartite motif containing 27. (513 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (291 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (674 aa)
ENSPCOP00000013298Uncharacterized protein. (378 aa)
VPS26AUncharacterized protein. (327 aa)
HSPB8Heat shock protein family B (small) member 8; Belongs to the small heat shock protein (HSP20) family. (196 aa)
CISD2ZnF_CDGSH domain-containing protein. (135 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (455 aa)
ENSPCOP00000013979Uncharacterized protein. (488 aa)
MEFVMEFV innate immuity regulator, pyrin. (772 aa)
WDR6WD repeat domain 6. (1149 aa)
SOGA3Uncharacterized protein. (948 aa)
TSPOTranslocator protein. (169 aa)
ENSPCOP00000014679Uncharacterized protein. (218 aa)
ENSPCOP00000014900PX domain-containing protein. (371 aa)
BNIP3Uncharacterized protein. (235 aa)
CHMP4BCharged multivesicular body protein 4B. (224 aa)
ENSPCOP00000015479Uncharacterized protein. (493 aa)
PIK3CAPhosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (544 aa)
ENSPCOP00000015642DJ-1_PfpI domain-containing protein. (175 aa)
KDM4AUncharacterized protein. (1064 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (472 aa)
OSBPL7Oxysterol-binding protein; Belongs to the OSBP family. (842 aa)
WDR41WD repeat domain 41. (438 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
TSC2TSC complex subunit 2. (1814 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (460 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ENSPCOP00000016492Sec8_exocyst domain-containing protein. (277 aa)
SLC25A5Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
TBK1TANK binding kinase 1. (690 aa)
DHRSXDehydrogenase/reductase X-linked. (292 aa)
SMCR8SMCR8-C9orf72 complex subunit. (938 aa)
SNX30Sorting nexin family member 30. (408 aa)
GPR137G protein-coupled receptor 137. (459 aa)
ENSPCOP00000017250ZnF_CDGSH domain-containing protein. (120 aa)
CAPNS1Calpain small subunit 1. (302 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2635 aa)
KIAA0408KIAA0408. (690 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
UVRAGUV radiation resistance associated. (701 aa)
PAFAH1B2Platelet activating factor acetylhydrolase 1b catalytic subunit 2. (229 aa)
ABL2Tyrosine-protein kinase. (1154 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3290 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (703 aa)
PIK3R2Uncharacterized protein. (726 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (221 aa)
POLDIP2DNA polymerase delta interacting protein 2. (368 aa)
NPC1NPC intracellular cholesterol transporter 1. (1213 aa)
SNX7PX domain-containing protein. (451 aa)
SUPT5HTranscription elongation factor SPT5. (1087 aa)
FBXO7F-box protein 7. (513 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (704 aa)
EP300E1A binding protein p300. (2424 aa)
VDAC1Uncharacterized protein. (283 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (472 aa)
WDR45Uncharacterized protein. (361 aa)
LOC105821266Sorting nexin; Involved in several stages of intracellular trafficking. (399 aa)
BCL2L1BCL2 like 1. (233 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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