STRINGSTRING
VEGFC VEGFC HDAC9 HDAC9 ENSPCOP00000021466 ENSPCOP00000021466 IQSEC1 IQSEC1 ATOH8 ATOH8 RIN2 RIN2 ANGPT1 ANGPT1 MET MET ENSPCOP00000022475 ENSPCOP00000022475 ITGB1BP1 ITGB1BP1 PLPP3 PLPP3 TGFB1 TGFB1 SMOC2 SMOC2 SASH1 SASH1 ITGA3 ITGA3 VEGFA VEGFA PLCG1 PLCG1 CLASP2 CLASP2 THBS1 THBS1 MAPRE2 MAPRE2 GLIPR2 GLIPR2 BCAS3 BCAS3 CD40 CD40 BCAR1 BCAR1 VIL1 VIL1 HYAL1 HYAL1 ARF6 ARF6 TGFB2 TGFB2 TGFBR2 TGFBR2 GRN GRN RHOB RHOB FGF16 FGF16 EMC10 EMC10 RAB25 RAB25 MTOR MTOR JCAD JCAD GATA2 GATA2 LOC105822640 LOC105822640 HDAC7 HDAC7 PRKD1 PRKD1 FGFR1 FGFR1 NFE2L2 NFE2L2 WNT7A WNT7A P2RX4 P2RX4 PDGFB PDGFB HMOX1 HMOX1 PIK3CD PIK3CD ADAM17 ADAM17 HDAC6 HDAC6 PRKCA PRKCA AGT AGT SOX9 SOX9 CALR CALR TSTA3 TSTA3 AKT1 AKT1 AKT3 AKT3 BMP4 BMP4 SIRT1 SIRT1 PTK2B PTK2B ALOX12 ALOX12 RTN4 RTN4 ITGA2 ITGA2 GPLD1 GPLD1 SP1 SP1 FOXC2 FOXC2 FGF7 FGF7 AMOT AMOT PRKCE PRKCE ZNF580 ZNF580 HIF1A HIF1A AAMP AAMP PDPK1 PDPK1 KDR KDR CAPN7 CAPN7 ANXA1 ANXA1 SCARB1 SCARB1 HBEGF HBEGF LGMN LGMN RREB1 RREB1 PPM1F PPM1F CTSH CTSH CIB1 CIB1 PLK2 PLK2 ENPP2 ENPP2 WNT5A WNT5A TEK TEK ZC3H12A ZC3H12A GATA3 GATA3 PTGS2 PTGS2 NRP2 NRP2 NRP1 NRP1 NUS1 NUS1 SRC SRC CLASP1 CLASP1 IFNG IFNG EPB41L4B EPB41L4B ETS1 ETS1 FGF18 FGF18 MAP2K3 MAP2K3 MAP4K4 MAP4K4 FGF2 FGF2 HSPB1 HSPB1 CCBE1 CCBE1 TDGF1 TDGF1 FGF10 FGF10 WNT7B WNT7B ENSPCOP00000009588 ENSPCOP00000009588 FLT4 FLT4 DOCK5 DOCK5 NOS3 NOS3 ANGPT4 ANGPT4 ATP5F1B ATP5F1B FGF1 FGF1 FOXP1 FOXP1 ATP5F1A ATP5F1A ENSPCOP00000011221 ENSPCOP00000011221 ROCK2 ROCK2 PLCG2 PLCG2 RHOJ RHOJ BSG BSG MMP9 MMP9 TACR1 TACR1 RRAS RRAS PRKD2 PRKD2 PROX1 PROX1 HAS2 HAS2 EPB41L5 EPB41L5 EGF EGF ADGRA2 ADGRA2 BMPR2 BMPR2 PIK3CG PIK3CG SPARC SPARC PIK3CB PIK3CB MAP3K3 MAP3K3
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (367 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1023 aa)
ENSPCOP00000021466Uncharacterized protein. (46 aa)
IQSEC1IQ motif and Sec7 domain 1. (991 aa)
ATOH8Atonal bHLH transcription factor 8. (313 aa)
RIN2Ras and Rab interactor 2. (924 aa)
ANGPT1Angiopoietin 1. (408 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1397 aa)
ENSPCOP00000022475Uncharacterized protein. (173 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
PLPP3acidPPc domain-containing protein. (312 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SMOC2SPARC related modular calcium binding 2. (457 aa)
SASH1SAM and SH3 domain containing 1. (1248 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1304 aa)
CLASP2Uncharacterized protein. (1515 aa)
THBS1Thrombospondin 1. (1185 aa)
MAPRE2Microtubule associated protein RP/EB family member 2. (274 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (154 aa)
BCAS3BCAS3 microtubule associated cell migration factor. (791 aa)
CD40CD40 molecule. (281 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (902 aa)
VIL1Villin 1. (827 aa)
HYAL1Hyaluronidase. (435 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
GRNGranulin precursor. (591 aa)
RHOBRas homolog family member B. (196 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
EMC10ER membrane protein complex subunit 10. (261 aa)
RAB25RAB25, member RAS oncogene family. (213 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
JCADJunctional cadherin 5 associated. (1332 aa)
GATA2GATA binding protein 2. (445 aa)
LOC105822640Integrin beta; Belongs to the integrin beta chain family. (454 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (991 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (860 aa)
FGFR1Fibroblast growth factor receptor. (846 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (190 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (402 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ADAM17ADAM metallopeptidase domain 17. (757 aa)
HDAC6Histone deacetylase 6. (1203 aa)
PRKCAUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (575 aa)
AGTAngiotensinogen; Belongs to the serpin family. (484 aa)
SOX9SRY-box transcription factor 9. (505 aa)
CALRCalreticulin. (417 aa)
TSTA3Tissue specific transplantation antigen P35B. (321 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SIRT1Sirtuin 1. (743 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (967 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
RTN4Reticulon. (1195 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1129 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (813 aa)
SP1Sp1 transcription factor. (788 aa)
FOXC2Forkhead box C2. (503 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
AMOTAngiomotin. (1083 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
ZNF580Zinc finger protein 580. (172 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
AAMPAngio associated migratory cell protein. (391 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
CAPN7Calpain 7; Belongs to the peptidase C2 family. (703 aa)
ANXA1Annexin. (346 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (461 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
LGMNLegumain. (433 aa)
RREB1Ras responsive element binding protein 1. (1731 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (444 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (336 aa)
CIB1Calcium and integrin binding 1. (191 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (911 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (598 aa)
GATA3Uncharacterized protein. (444 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (932 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
SRCTyrosine-protein kinase. (543 aa)
CLASP1Cytoplasmic linker associated protein 1. (1552 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
EPB41L4BErythrocyte membrane protein band 4.1 like 4B. (903 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4. (1352 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (394 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (206 aa)
CCBE1Collagen and calcium binding EGF domains 1. (408 aa)
TDGF1Teratocarcinoma-derived growth factor 1. (186 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ENSPCOP00000009588Uncharacterized protein. (316 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1341 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1723 aa)
NOS3Nitric oxide synthase 3. (994 aa)
ANGPT4Angiopoietin 4. (499 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (529 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FOXP1Forkhead box P1. (693 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (571 aa)
ENSPCOP00000011221FERM domain-containing protein. (471 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1361 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1233 aa)
RHOJRas homolog family member J. (215 aa)
BSGBasigin (Ok blood group). (385 aa)
MMP9Matrix metallopeptidase 9. (709 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
RRASRAS related. (220 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
PROX1Prospero homeobox 1. (737 aa)
HAS2Hyaluronan synthase 2. (552 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (731 aa)
EGFEpidermal growth factor. (1132 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1314 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (653 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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