STRINGSTRING
SMAD2 SMAD2 GCNT2 GCNT2 TGFB2 TGFB2 TGFBR2 TGFBR2 MTOR MTOR BMP7 BMP7 LEF1 LEF1 NOTCH1 NOTCH1 JAG1 JAG1 LOC105824853 LOC105824853 EMP2 EMP2 TGFB3 TGFB3 AXIN2 AXIN2 IL6 IL6 LOC105824854 LOC105824854 IL1B IL1B FERMT2 FERMT2 MDK MDK TCF7L2 TCF7L2 ISL1 ISL1 BCL9L BCL9L RGCC RGCC ACVR1 ACVR1 SNAI1 SNAI1 TGFBR1 TGFBR1 EZH2 EZH2 WWTR1 WWTR1 ALX1 ALX1 COL1A1 COL1A1 ENG ENG LOXL2 LOXL2 DAB2 DAB2 PDPN PDPN LOC105826870 LOC105826870 SMAD3 SMAD3 CTNNB1 CTNNB1 TGFB1 TGFB1 ZNF703 ZNF703 SMAD4 SMAD4 GLIPR2 GLIPR2 CRB2 CRB2 SDCBP SDCBP TIAM1 TIAM1 BMP4 BMP4 FOXC1 FOXC1 OLFM1 OLFM1 TGFB1I1 TGFB1I1 ENSPCOP00000030477 ENSPCOP00000030477 BMP2 BMP2 TBX20 TBX20 LRG1 LRG1 BAMBI BAMBI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD2Mothers against decapentaplegic homolog. (462 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (329 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2536 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
LEF1Lymphoid enhancer binding factor 1. (432 aa)
NOTCH1Notch receptor 1. (2420 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
LOC105824853Uncharacterized protein. (401 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
AXIN2Axin 2. (716 aa)
IL6Uncharacterized protein. (211 aa)
LOC105824854Uncharacterized protein. (312 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
FERMT2Fermitin family member 2. (693 aa)
MDKMidkine. (143 aa)
TCF7L2Transcription factor 7 like 2. (619 aa)
ISL1ISL LIM homeobox 1. (349 aa)
BCL9LBCL9 like. (1497 aa)
RGCCRegulator of cell cycle. (137 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (421 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
ALX1ALX homeobox 1. (326 aa)
COL1A1Collagen type I alpha 1 chain. (1461 aa)
ENGEndoglin. (657 aa)
LOXL2Lysyl oxidase like 2. (775 aa)
DAB2DAB adaptor protein 2. (769 aa)
PDPNPodoplanin. (211 aa)
LOC105826870Uncharacterized protein. (244 aa)
SMAD3Mothers against decapentaplegic homolog. (443 aa)
CTNNB1Catenin beta 1. (781 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ZNF703Zinc finger protein 703. (589 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (154 aa)
CRB2Crumbs cell polarity complex component 2. (1230 aa)
SDCBPUncharacterized protein. (298 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1590 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
FOXC1Forkhead box C1. (535 aa)
OLFM1Olfactomedin 1. (485 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
ENSPCOP00000030477PDZ domain-containing protein. (263 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
TBX20T-box transcription factor 20. (447 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
Your Current Organism:
Propithecus coquereli
NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli
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