39 items (Propithecus coquereli) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NKX6-1	NK6 homeobox 1. (367 aa)
	LDLR	Low density lipoprotein receptor. (902 aa)
	SOX11	Transcription factor SOX. (442 aa)
	SKI	SKI proto-oncogene. (718 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (613 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (385 aa)
	DLX1	Distal-less homeobox 1. (255 aa)
	HMGA2	Uncharacterized protein. (117 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	DLX2	Distal-less homeobox 2. (328 aa)
	LINGO1	Leucine rich repeat and Ig domain containing 1. (621 aa)
	MBD1	Methyl-CpG binding domain protein 1. (656 aa)
	NOTCH1	Notch receptor 1. (2420 aa)
	HES5	Orange domain-containing protein. (94 aa)
	LOC105809759	CCHC-type domain-containing protein. (176 aa)
	RB1	RB transcriptional corepressor 1. (787 aa)
	NF2	Neurofibromin 2. (596 aa)
	DICER1	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1922 aa)
	RNF10	Ring finger protein 10. (807 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	DUSP10	Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
	NF1	Neurofibromin 1. (2841 aa)
	LIN28A	CCHC-type domain-containing protein. (209 aa)
	CDKN2B	Cyclin dependent kinase inhibitor 2B. (138 aa)
	SIRT2	Sirtuin 2. (469 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (224 aa)
	DAAM2	Dishevelled associated activator of morphogenesis 2. (1077 aa)
	PITX3	Homeobox protein. (302 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
	ABCC8	ATP binding cassette subfamily C member 8. (1582 aa)
	ID4	Inhibitor of DNA binding 4, HLH protein. (161 aa)
	TSPO	Translocator protein. (169 aa)
	ENSPCOP00000015413	CCHC-type domain-containing protein. (191 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (421 aa)
	CERS2	Ceramide synthase 2. (411 aa)
	NKX6-2	NK6 homeobox 2. (277 aa)
	TMEM98	Transmembrane protein 98. (226 aa)
	GPR37L1	G protein-coupled receptor 37 like 1. (481 aa)
	SOX10	SRY-box transcription factor 10. (468 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDKN2B	CTNNB1	ENSPCOP00000029141	ENSPCOP00000022753	Cyclin dependent kinase inhibitor 2B.	Catenin beta 1.	0.474
CDKN2B	RB1	ENSPCOP00000029141	ENSPCOP00000011104	Cyclin dependent kinase inhibitor 2B.	RB transcriptional corepressor 1.	0.417
CDKN2B	TP53	ENSPCOP00000029141	ENSPCOP00000031758	Cyclin dependent kinase inhibitor 2B.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.961
CTNNB1	CDKN2B	ENSPCOP00000022753	ENSPCOP00000029141	Catenin beta 1.	Cyclin dependent kinase inhibitor 2B.	0.474
CTNNB1	DAAM2	ENSPCOP00000022753	ENSPCOP00000012571	Catenin beta 1.	Dishevelled associated activator of morphogenesis 2.	0.573
CTNNB1	HMGA2	ENSPCOP00000022753	ENSPCOP00000000692	Catenin beta 1.	Uncharacterized protein.	0.481
CTNNB1	LDLR	ENSPCOP00000022753	ENSPCOP00000030084	Catenin beta 1.	Low density lipoprotein receptor.	0.585
CTNNB1	NF2	ENSPCOP00000022753	ENSPCOP00000011118	Catenin beta 1.	Neurofibromin 2.	0.619
CTNNB1	NOG	ENSPCOP00000022753	ENSPCOP00000000944	Catenin beta 1.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.403
CTNNB1	NOTCH1	ENSPCOP00000022753	ENSPCOP00000004691	Catenin beta 1.	Notch receptor 1.	0.742
CTNNB1	PITX3	ENSPCOP00000022753	ENSPCOP00000013452	Catenin beta 1.	Homeobox protein.	0.488
CTNNB1	SIRT2	ENSPCOP00000022753	ENSPCOP00000011807	Catenin beta 1.	Sirtuin 2.	0.593
CTNNB1	SOX10	ENSPCOP00000022753	ENSPCOP00000020758	Catenin beta 1.	SRY-box transcription factor 10.	0.794
CTNNB1	SOX11	ENSPCOP00000022753	ENSPCOP00000030284	Catenin beta 1.	Transcription factor SOX.	0.710
CTNNB1	TP53	ENSPCOP00000022753	ENSPCOP00000031758	Catenin beta 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.635
DAAM2	CTNNB1	ENSPCOP00000012571	ENSPCOP00000022753	Dishevelled associated activator of morphogenesis 2.	Catenin beta 1.	0.573
DICER1	TP53	ENSPCOP00000021750	ENSPCOP00000031758	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.526
DLX1	DLX2	ENSPCOP00000000631	ENSPCOP00000003437	Distal-less homeobox 1.	Distal-less homeobox 2.	0.902
DLX2	DLX1	ENSPCOP00000003437	ENSPCOP00000000631	Distal-less homeobox 2.	Distal-less homeobox 1.	0.902
DLX2	SOX10	ENSPCOP00000003437	ENSPCOP00000020758	Distal-less homeobox 2.	SRY-box transcription factor 10.	0.445