(39 nodes) Phosphatidylinositol 3-kinase signaling network (Propithecus coquereli)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPCOP00000021900	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (222 aa)
	PIK3R5	Phosphoinositide-3-kinase regulatory subunit 5. (879 aa)
	LTK	Tyrosine-protein kinase receptor. (888 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	C1QBP	Uncharacterized protein. (281 aa)
	MYO16	Myosin XVI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1806 aa)
	XBP1	BZIP domain-containing protein. (377 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (471 aa)
	ENSPCOP00000005855	Uncharacterized protein. (259 aa)
	EDN1	Endothelin 1. (193 aa)
	GATA3	Uncharacterized protein. (444 aa)
	PRR5L	Proline rich 5 like. (368 aa)
	SIRT2	Sirtuin 2. (469 aa)
	ENSPCOP00000012847	IG domain-containing protein. (167 aa)
	CD28	CD28 molecule. (220 aa)
	NYAP1	Neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1. (840 aa)
	PIK3CA	Phosphatidylinositol 3-kinase catalytic subunit type 3. (933 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	NYAP2	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2. (655 aa)
	PIK3R2	Uncharacterized protein. (726 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	CD160	CD160 molecule. (220 aa)
	IGF1	Insulin like growth factor 1. (208 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	PIK3C2B	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
	PEAR1	Platelet endothelial aggregation receptor 1. (1035 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1350 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1252 aa)
	PLEKHA1	Pleckstrin homology domain containing A1. (400 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (480 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (440 aa)
	KBTBD2	Kelch repeat and BTB domain containing 2. (623 aa)
	PREX2	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1470 aa)
	SERPINA12	Serpin family A member 12; Belongs to the serpin family. (413 aa)
	NF1	Neurofibromin 1. (2841 aa)
	ERBB3	Erb-b2 receptor tyrosine kinase 3. (1337 aa)

Your Current Organism:

Propithecus coquereli

NCBI taxonomy Id: 379532
Other names: P. coquereli, Propithecus verreauxi coquereli

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	CD28	ENSPCOP00000028969	ENSPCOP00000012951	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	CD28 molecule.	0.442
AKT1	EDN1	ENSPCOP00000028969	ENSPCOP00000006922	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Endothelin 1.	0.465
AKT1	ERBB2	ENSPCOP00000028969	ENSPCOP00000028204	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Receptor protein-tyrosine kinase.	0.488
AKT1	ERBB3	ENSPCOP00000028969	ENSPCOP00000027625	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Erb-b2 receptor tyrosine kinase 3.	0.658
AKT1	IGF1R	ENSPCOP00000028969	ENSPCOP00000021856	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase receptor.	0.406
AKT1	NF1	ENSPCOP00000028969	ENSPCOP00000026338	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Neurofibromin 1.	0.474
AKT1	PIK3CA	ENSPCOP00000028969	ENSPCOP00000015588	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.975
AKT1	PIK3CB	ENSPCOP00000028969	ENSPCOP00000016466	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.952
AKT1	PIK3CD	ENSPCOP00000028969	ENSPCOP00000030279	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.938
AKT1	PIK3CG	ENSPCOP00000028969	ENSPCOP00000015902	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.956
AKT1	PIK3R1	ENSPCOP00000028969	ENSPCOP00000018534	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.954
AKT1	PIK3R2	ENSPCOP00000028969	ENSPCOP00000018359	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.917
AKT1	PIK3R5	ENSPCOP00000028969	ENSPCOP00000023311	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 5.	0.861
AKT1	PREX2	ENSPCOP00000028969	ENSPCOP00000031369	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2.	0.414
AKT1	PTEN	ENSPCOP00000028969	ENSPCOP00000001519	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.872
AKT1	SIRT2	ENSPCOP00000028969	ENSPCOP00000011807	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Sirtuin 2.	0.443
AKT1	XBP1	ENSPCOP00000028969	ENSPCOP00000003952	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BZIP domain-containing protein.	0.448
AKT1	ZFP36L1	ENSPCOP00000028969	ENSPCOP00000021052	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	ZFP36 ring finger protein like 1.	0.683
CD28	AKT1	ENSPCOP00000012951	ENSPCOP00000028969	CD28 molecule.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.442
CD28	PIK3CD	ENSPCOP00000012951	ENSPCOP00000030279	CD28 molecule.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.840